Search Results - "Hingorani, A. D."

C‐reactive protein and coronary heart disease: a critical review by Casas, J. P., Shah, T., Hingorani, A. D., Danesh, J., Pepys, M. B.

“… Modestly elevated baseline concentrations of C‐reactive protein (CRP), the classical acute phase protein, are associated with the long‐term risk of coronary…”
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Is systemic inflammation a missing link between periodontitis and hypertension? Results from two large population‐based surveys by Muñoz Aguilera, E., Leira, Y., Miró Catalina, Q., Orlandi, M., Czesnikiewicz‐Guzik, M., Guzik, T. J., Hingorani, A. D., Nart, J., D’Aiuto, F.

“…Objective The primary objective was to investigate the relationship between periodontitis and hypertension in two independent large surveys. The secondary…”
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Human CRP Gene Polymorphism Influences CRP Levels: Implications for the Prediction and Pathogenesis of Coronary Heart Disease by Brull, D J, Serrano, Norma, Zito, F, Jones, Lisa, Montgomery, H E, Rumley, A, Sharma, Pankaj, Lowe, G D.O, World, M J, Humphries, S E, Hingorani, A D

“…OBJECTIVE—C-reactive protein (CRP) concentrations are predictive of cardiovascular disease, and levels are heritable, in part. We identified novel…”
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Are there socioeconomic inequalities in cardiovascular risk factors in childhood, and are they mediated by adiposity? Findings from a prospective cohort study by Howe, L.D, Galobardes, B, Sattar, N, Hingorani, A.D, Deanfield, J, Ness, A.R, Davey-Smith, G, Lawlor, D.A

“…Background: Socioeconomic gradients in adiposity were not present during childhood for previous generations, but have emerged in contemporary children. It is…”
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Maternal endothelial function and serum concentrations of placental growth factor and soluble endoglin in women with abnormal placentation by Savvidou, M. D., Noori, M., Anderson, J. M., Hingorani, A. D., Nicolaides, K. H.

“…Objectives To determine whether maternal serum concentrations of placental growth factor (PlGF) and soluble endoglin (sEng) are altered in women who…”
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Variants of ADRA2A are associated with fasting glucose, blood pressure, body mass index and type 2 diabetes risk: meta-analysis of four prospective studies by Talmud, P. J., Cooper, J. A., Gaunt, T., Holmes, M. V., Shah, S., Palmen, J., Drenos, F., Shah, T., Kumari, M., Kivimaki, M., Whittaker, J., Lawlor, D. A., Day, I. N., Hingorani, A. D., Casas, J. P., Humphries, S. E.

“…Aims/hypothesis We quantified the effect of ADRA2A (encoding α-2 adrenergic receptor) variants on metabolic traits and type 2 diabetes risk, as reported in…”
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Glu298Asp Endothelial Nitric Oxide Synthase Gene Polymorphism Interacts With Environmental and Dietary Factors to Influence Endothelial Function by Leeson, C P.M, Hingorani, A D, Mullen, M J, Jeerooburkhan, N, Kattenhorn, M, Cole, T J, Muller, D P.R, Lucas, A, Humphries, S E, Deanfield, J E

“…An endothelial nitric oxide synthase (eNOS) gene polymorphism (Glu298Asp) has been associated with cardiovascular disease. We investigated whether carriage of…”
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Tau gene and Parkinson’s disease: a case–control study and meta-analysis by Healy, D G, Abou-Sleiman, P M, Lees, A J, Casas, J P, Quinn, N, Bhatia, K, Hingorani, A D, Wood, N W

“…Objective: To investigate whether the tau H1 haplotype is a genetic risk factor in Parkinson’s disease and to report a meta-analysis on all previously…”
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Comparison of variance estimators for meta-analysis of instrumental variable estimates by Schmidt, A F, Hingorani, A D, Jefferis, B J, White, J, Groenwold, Rhh, Dudbridge, F

“…Mendelian randomization studies perform instrumental variable (IV) analysis using genetic IVs. Results of individual Mendelian randomization studies can be…”
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Comparative clinical- and cost-effectiveness of candesartan and losartan in the management of hypertension and heart failure: a systematic review, meta- and cost-utility analysis by Grosso, A M, Bodalia, P N, Macallister, R J, Hingorani, A D, Moon, J C, Scott, M A

“…The UK National Health Service (NHS) currently spends in excess of £250 million per annum on angiotensin II receptor blockers (ARBs) for the treatment of…”
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Evaluation of common genetic variants identified by GWAS for early onset and morbid obesity in population-based samples by den Hoed, M, Luan, J, Langenberg, C, Cooper, C, Sayer, A A, Jameson, K, Kumari, M, Kivimaki, M, Hingorani, A D, Grøntved, A, Khaw, K-T, Ekelund, U, Wareham, N J, Loos, R J F

“…Background: Meta-analysis of case–control genome-wide association studies (GWAS) for early onset and morbid obesity identified four variants in/near the PRL ,…”
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Acute systemic inflammation impairs endothelium-dependent dilatation in humans by HINGORANI, A. D, CROSS, J, MACALLISTER, R. J, VALLANCE, P, KHARBANDA, R. K, MULLEN, M. J, BHAGAT, K, TAYLOR, M, DONALD, A. E, PALACIOS, M, GRIFFIN, G. E, DEANFIELD, J. E

“…We tested the hypothesis that endothelial dysfunction underlies the association between an acute inflammatory episode and the transiently increased risk of a…”
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Optimisation of antihypertensive treatment by crossover rotation of four major classes by Dickerson, JE Claire, Hingorani, Aroon D, Ashby, Michael J, Palmer, Christopher R, Brown, Morris J

“…Most comparisons of antihypertensive drugs aee undertaken in parallel groups. We undertook a crossover rotation of the four main classes of antihypertensive…”
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Is a fatty liver (always or ever) bad for the heart? by Parisinos, C A, Hingorani, A D

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Chronic inflammation, periodontitis and cardiovascular diseases by Hingorani, AD, D'Aiuto, F

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A simple computer program for guiding management of cardiovascular risk factors and prescribing by Hingorani, Aroon D, Vallance, Patrick

“…Abstract Objective: To describe, and to test against trial data, a simple and flexible computer program for calculating cardiovascular risk in individual…”
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Common genetic variation in a basal promoter element alters DDAH2 expression in endothelial cells by Jones, L.C, Tran, C.T.L, Leiper, J.M, Hingorani, A.D, Vallance, P

“…Synthesis of the vasodilator nitric oxide (NO) can be inhibited by the endogenous methylarginines l-NMMA and ADMA. ADMA is elevated in a number of…”
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Human monoclonal IgG anticardiolipin antibodies induce nitric oxide synthase expression by Alves, J. Delgado, Clapp, B.R., Stidwill, R., Chen, P.P., Hingorani, A.D., Singer, M., Isenberg, D.A.

“…Antiphospholipid antibodies are associated with increased risk of thrombosis, particularly as in antiphospholipid syndrome. This study aims to determine the…”
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Renin-angiotensin system gene polymorphisms influence blood pressure and the response to angiotensin converting enzyme inhibition by Hingorani, A D, Jia, H, Stevens, P A, Hopper, R, Dickerson, J E, Brown, M J

“…To investigate the relationship between polymorphisms in the angiotensin converting enzyme (ACE), angiotensinogen (AGT) and type 1 angiotensin-II (AT1R) genes…”
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Utility of genetic and non-genetic risk factors in prediction of type 2 diabetes: Whitehall II prospective cohort study by Talmud, Philippa J, Hingorani, Aroon D, Cooper, Jackie A, Marmot, Michael G, Brunner, Eric J, Kumari, Meena, Kivimäki, Mika, Humphries, Steve E

“…Objectives To assess the performance of a panel of common single nucleotide polymorphisms (genotypes) associated with type 2 diabetes in distinguishing…”
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