Search Results - "Hing, Zachary A"

BRD4 Profiling Identifies Critical Chronic Lymphocytic Leukemia Oncogenic Circuits and Reveals Sensitivity to PLX51107, a Novel Structurally Distinct BET Inhibitor by Ozer, Hatice Gulcin, El-Gamal, Dalia, Powell, Ben, Hing, Zachary A, Blachly, James S, Harrington, Bonnie, Mitchell, Shaneice, Grieselhuber, Nicole R, Williams, Katie, Lai, Tzung-Huei, Alinari, Lapo, Baiocchi, Robert A, Brinton, Lindsey, Baskin, Elizabeth, Cannon, Matthew, Beaver, Larry, Goettl, Virginia M, Lucas, David M, Woyach, Jennifer A, Sampath, Deepa, Lehman, Amy M, Yu, Lianbo, Zhang, Jiazhong, Ma, Yan, Zhang, Ying, Spevak, Wayne, Shi, Songyuan, Severson, Paul, Shellooe, Rafe, Carias, Heidi, Tsang, Garson, Dong, Ken, Ewing, Todd, Marimuthu, Adhirai, Tantoy, Christina, Walters, Jason, Sanftner, Laura, Rezaei, Hamid, Nespi, Marika, Matusow, Bernice, Habets, Gaston, Ibrahim, Prabha, Zhang, Chao, Mathé, Ewy A, Bollag, Gideon, Byrd, John C, Lapalombella, Rosa

“…Bromodomain and extra-terminal (BET) family proteins are key regulators of gene expression in cancer. Herein, we utilize BRD4 profiling to identify critical…”
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Dysregulation of PRMT5 in chronic lymphocytic leukemia promotes progression with high risk of Richter’s transformation by Hing, Zachary A., Walker, Janek S., Whipp, Ethan C., Brinton, Lindsey, Cannon, Matthew, Zhang, Pu, Sher, Steven, Cempre, Casey B., Brown, Fiona, Smith, Porsha L., Agostinelli, Claudio, Pileri, Stefano A., Skinner, Jordan N., Williams, Katie, Phillips, Hannah, Shaffer, Jami, Beaver, Larry P., Pan, Alexander, Shin, Kyle, Gregory, Charles T., Ozer, Gulcin H., Yilmaz, Selen A., Harrington, Bonnie K., Lehman, Amy M., Yu, Lianbo, Coppola, Vincenzo, Yan, Pearlly, Scherle, Peggy, Wang, Min, Pitis, Philip, Xu, Chaoyi, Vaddi, Kris, Chen-Kiang, Selina, Woyach, Jennifer, Blachly, James S., Alinari, Lapo, Yang, Yiping, Byrd, John C., Baiocchi, Robert A., Blaser, Bradley W., Lapalombella, Rosa

“…Richter’s Transformation (RT) is a poorly understood and fatal progression of chronic lymphocytic leukemia (CLL) manifesting histologically as diffuse large…”
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Recurrent XPO1 mutations alter pathogenesis of chronic lymphocytic leukemia by Walker, Janek S, Hing, Zachary A, Harrington, Bonnie, Baumhardt, Jordan, Ozer, Hatice Gulcin, Lehman, Amy, Giacopelli, Brian, Beaver, Larry, Williams, Katie, Skinner, Jordan N, Cempre, Casey B, Sun, Qingxiang, Shacham, Sharon, Stromberg, Benjamin R, Summers, Matthew K, Abruzzo, Lynne V, Rassenti, Laura, Kipps, Thomas J, Parikh, Sameer, Kay, Neil E, Rogers, Kerry A, Woyach, Jennifer A, Coppola, Vincenzo, Chook, Yuh Min, Oakes, Christopher, Byrd, John C, Lapalombella, Rosa

“…Exportin 1 (XPO1/CRM1) is a key mediator of nuclear export with relevance to multiple cancers, including chronic lymphocytic leukemia (CLL). Whole exome…”
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Rare t(X;14)(q28;q32) translocation reveals link between MTCP1 and chronic lymphocytic leukemia by Walker, Janek S., Hing, Zachary A., Sher, Steven, Cronin, James, Williams, Katie, Harrington, Bonnie, Skinner, Jordan N., Cempre, Casey B., Gregory, Charles T., Pan, Alexander, Yano, Max, Beaver, Larry P., Walker, Brandi R., Labanowska, Jadwiga M., Heerema, Nyla A., Mrózek, Krzysztof, Woyach, Jennifer A., Ruppert, Amy S., Lehman, Amy, Ozer, Hatice Gulcin, Coppola, Vincenzo, Yan, Pearlly, Byrd, John C., Blachly, James S., Lapalombella, Rosa

“…Rare, recurrent balanced translocations occur in a variety of cancers but are often not functionally interrogated. Balanced translocations with the…”
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Characterization of coding synonymous and non-synonymous variants in ADAMTS13 using ex vivo and in silico approaches by Edwards, Nathan C, Hing, Zachary A, Perry, Avital, Blaisdell, Adam, Kopelman, David B, Fathke, Robert, Plum, William, Newell, Jordan, Allen, Courtni E, S, Geetha, Shapiro, Aaron, Okunji, Chinyere, Kosti, Idit, Shomron, Noam, Grigoryan, Vahan, Przytycka, Teresa M, Sauna, Zuben E, Salari, Raheleh, Mandel-Gutfreund, Yael, Komar, Anton A, Kimchi-Sarfaty, Chava

“…Synonymous variations, which are defined as codon substitutions that do not change the encoded amino acid, were previously thought to have no effect on the…”
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Multiple in silico tools predict phenotypic manifestations in congenital thrombotic thrombocytopenic purpura by Hing, Zachary A., Schiller, Tal, Wu, Andrew, Hamasaki‐Katagiri, Nobuko, Struble, Evi Budo, Russek‐Cohen, Estelle, Kimchi‐Sarfaty, Chava

“…Summary Congenital thrombotic thrombocytopenic purpura (cTTP) is a rare, recessively inherited genetic disorder with varying clinical presentation that is…”
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Selinexor is effective in acquired resistance to ibrutinib and synergizes with ibrutinib in chronic lymphocytic leukemia by Hing, Zachary A., Mantel, Rose, Beckwith, Kyle A., Guinn, Daphne, Williams, Erich, Smith, Lisa L., Williams, Katie, Johnson, Amy J., Lehman, Amy M., Byrd, John C., Woyach, Jennifer A., Lapalombella, Rosa

“…Despite the therapeutic efficacy of ibrutinib in chronic lymphocytic leukemia (CLL), complete responses are infrequent, and acquired resistance to Bruton…”
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Eμ-TCL1xMyc: A Novel Mouse Model for Concurrent CLL and B-Cell Lymphoma by Lucas, Fabienne, Rogers, Kerry A, Harrington, Bonnie K, Pan, Alexander, Yu, Lianbo, Breitbach, Justin, Bundschuh, Ralf, Goettl, Virginia M, Hing, Zachary A, Kanga, Parviz, Mantel, Rose, Sampath, Deepa, Smith, Lisa L, Wasmuth, Ronni, White, Danielle K, Yan, Pearlly, Byrd, John C, Lapalombella, Rosa, Woyach, Jennifer A

“…Aberrant Myc expression is a major factor in the pathogenesis of aggressive lymphoma, and these lymphomas, while clinically heterogeneous, often are resistant…”
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Single‐nucleotide variations defining previously unreported ADAMTS13 haplotypes are associated with differential expression and activity of the VWF‐cleaving protease in a Salvadoran congenital thrombotic thrombocytopenic purpura family by Kim, Benjamin, Hing, Zachary A., Wu, Andrew, Schiller, Tal, Struble, Evi B., Liuwantara, David, Kempert, Pamela H., Broxham, Eric J., Edwards, Nathan C., Marder, Victor J., Simhadri, Vijaya L., Sauna, Zuben E., Howard, Tom E., Kimchi‐Sarfaty, Chava

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Dysregulation of PRMT5 in Chronic Lymphocytic Leukemia Supports Transformation to Diffuse Large B-Cell Lymphoma by Whipp, Ethan, Hing, Zachary A, Walker, Janek S., Sher, Steven, Cempre, Casey B., Brown, Fiona, Agostinelli, Claudio, Pileri, Stefano A, Williams, Katie, Beaver, Larry, Pan, Alexander, Gregory, Charles T., Yan, Pearlly S., Scherle, Peggy, Wang, Min, Vaddi, Kris, Chen-Kiang, Selina, Woyach, Jennifer A., Blachly, James S., Alinari, Lapo, Yang, Yiping, Baiocchi, Robert A., Blaser, Bradley W, Lapalombella, Rosa

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Exploring the Role of the Recurrent Exportin 1 (XPO1/CRM1) Mutations E571G and E571K in Chronic Lymphocytic Leukemia by Hing, Zachary A., Blachly, James S., Goettl, Virginia M., Singh, Guramrit, Byrd, John C., Lapalombella, Rosa

“…Background Exportin 1 (XPO1/CRM1) is a critical component of the nuclear to cytoplasmic export machinery. As such, XPO1 shuttles tumor suppressor proteins…”
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Abstract 2260: Evaluating a rare t(X;14)(q28;q32) translocation reveals MTCP1 as a driving factor in chronic lymphocytic leukemia by Walker, Janek S., Hing, Zachary A., Sher, Steven, Cronin, James, Williams, Katie, Harrington, Bonnie, Skinner, Jordan N., Cempre, Casey B., Gregory, Charles T., Yano, Max, Beaver, Larry P., Walker, Brandi R., Labanowska, Jadwiga M., Heerema, Nyla A., Mrozek, Krzysztof, Woyach, Jennifer A., Ruppert, Amy S., Lehman, Amy, Ozer, Hatice Gulcin, Coppola, Vincenzo, Byrd, John C., Blachly, James S., Lapalombella, Rosa

“…Chronic lymphocytic leukemia (CLL) is the most prevalent adult leukemia in Western countries and is spelled by substantial genetic and clinical heterogeneity…”
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PRMT5 Initiates an Epigenetic Program That Promotes Progression of Chronic Lymphocytic Leukemia by Hing, Zachary A, Skinner, Jordan N., Beaver, Larry P., Lai, Tzung-Huei, Cempre, Casey B., Harrington, Bonnie K., Sampath, Deepa, Lehman, Amy M., Yu, Lianbo, Alinari, Lapo, Byrd, John C., Baiocchi, Robert A, Lapalombella, Rosa

“…Background: Epigenetic alterations that occur as a result of arginine methyltransferase activity play a critical role in normal biological functions, and…”
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CD37 in acute myeloid leukemia: a novel surface target for drug delivery by Jeremy, Erin, Artiga, Esthela, Elgamal, Sara, Cheney, Carolyn M, Eicher, Dalen, Zalponik, Kevan, Orwick, Shelley, Mao, Hsiao-Yin Charlene Charlene, Wasmuth, Ronni, Harrington, Bonnie K, Mustonen, Allison, Beshay, Peter, Halley, Patrick, Castro, Carlos, Williams, Katie E, Hing, Zachary A, Chen, Timothy L, Lucas, Christopher R, Vantangoli, Nicholas J, Lapalombella, Rosa, Grieselhuber, Nicole Renee, Mo, Xiaokui M, Hertlein, Erin, Muthusamy, Natarajan, Mundy-Bosse, Bethany L, Byrd, John C, Larkin, Karilyn

“…Acute myeloid leukemia (AML) is the most common and lethal leukemia in adults. AML consists of many genetic subtypes which limits broad applicability of…”
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The Eµ-Myc/TCL1 Transgenic Mouse As a New Aggressive B-Cell Malignancy Model Suitable for Preclinical Therapeutics Testing by Rogers, Kerry A., El-Gamal, Dalia, Bonnie, Harrington K., Zachary, Hing A., Virginia, Goettl M., Rose, Mantel, Smith, Lisa L., Yu, Lianbo, Johnson, Amy J., Byrd, John C., Lapalombella, Rosa, Woyach, Jennifer A.

“…Background: Aggressive B-cell lymphomas occurring in the setting of Chronic Lymphocytic Leukemia (CLL) as a large cell transformation are an important clinical…”
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Next generation XPO1 inhibitor shows improved efficacy and in vivo tolerability in hematologic malignancies by Hing, Zachary A., Fung, Ho Yee Joyce, Ranganathan, Parvathi, Mitchell, Shaneice, El-Gamal, Dalia, Woyach, Jennifer A., Williams, Katie, Goettl, Virginia M., Smith, Jordan, Yu, Xueyan, Meng, Xiaomei, Sun, Qingxiang, Cagatay, Tolga, Lehman, Amy M., Lucas, David M., Baloglu, Erkan, Shacham, Sharon, Kauffman, Michael G., Byrd, John C., Chook, Yuh Min, Garzon, Ramiro, Lapalombella, Rosa

“…The nuclear export receptor, Exportin 1 (XPO1), mediates transport of growth-regulatory proteins including tumor suppressors and is overactive in many cancers,…”
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A Novel Inhibitor of BET Family Bromodomains Demonstrates In Vivo and I n Vi tro Potency in B-Cell Malignancies by El-Gamal, Dalia, Hing, Zachary A., Mitchell, Shaneice, LaFollette, Taylor D., Brennan, Paul J., Flynn, Joseph M., Jones, Jeffrey A., Awan, Farrukh, Andritsos, Leslie A., Blachly, James S., Williams, Katie, Harrington, Bonnie K., Goettl, Virginia M., Woyach, Jennifer A., Lehman, Amy M., Yu, Lianbo, Byrd, John C., Lapalombella, Rosa

“…▪ Chronic Lymphocytic Leukemia (CLL) is a B-cell malignancy with aberrant activation of the B-cell receptor (BCR) pathway. Despite durable remissions with…”
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Next Generation XPO1 Inhibitor Shows Improved Efficacy and In Vivo Tolerability in Hematologic Malignancies by Hing, Zachary A., Fung, Ho Yee Joyce, Ranganathan, Parvathi, Mitchell, Shaneice, El-Gamal, Dalia, Woyach, Jennifer A., Williams, Katie, Goettl, Virginia M., Smith, Jordan L., Yu, Xueyan, Meng, Xiaomei, Sun, Qingxiang, Cagatay, Tolga, MacMillan, John B., Lehman, Amy M., Lucas, David M., Baloglu, Erkan, Shacham, Sharon, Kauffman, Michael, Byrd, John C., Chook, Yuh Min, Garzon, Ramiro, Lapalombella, Rosa

“…▪ Restoring nuclear localization of tumor suppressors by blocking exportin 1 (XPO1) holds promise as a new therapeutic paradigm in many cancers, including…”
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Single-Nucleotide Variations Defining Previously Unreported ADAMTS13 Haplotypes Are Associated With Differential Expression and Activity Of The VWF-Cleaving Protease In a Salvadoran Congenital Thrombotic Thrombocytopenic Purpura Family by Kim, Benjamin, Hing, Zachary A., Wu, Andrew, Schiller, Tal, Struble, Evi B., Liuwantara, David, Kempert, Pamela H., Broxham, Eric J., Edwards, Nathan C., Marder, Victor J., Simhadri, Vijaya L., Sauna, Zuben E., Howard, Tom E., Kimchi-Sarfaty, Chava

“…Although autosomal recessive hematologic disorders are individually rare and difficult to ascertain, studies involving one or more homozygous affected children…”
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Single-nucleotide variations defining previously unreported ADAMTS13 haplotypes are associated with differential expression and activity of the VWF-cleaving protease in a Salvadoran congenital thrombotic thrombocytopenic purpura family by Kim, Benjamin, Hing, Zachary A, Wu, Andrew, Schiller, Tal, Struble, Evi B, Liuwantara, David, Kempert, Pamela H, Broxham, Eric J, Edwards, Nathan C, Marder, Victor J, Simhadri, Vijaya L, Sauna, Zuben E, Howard, Tom E, Kimchi-Sarfaty, Chava

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