Search Results - "Hines, Wade M"

Identification and categorization of liver toxicity markers induced by a related pair of drugs by Chang, Ching-Wei, Beland, Frederick A, Hines, Wade M, Fuscoe, James C, Han, Tao, Chen, James J

“…Drug-induced liver injury (DILI) is the primary adverse event that results in the withdrawal of drugs from the market and a frequent reason for the failure of…”
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The Liver Toxicity Biomarker Study Phase I: Markers for the Effects of Tolcapone or Entacapone by McBurney, Robert N., Hines, Wade M., VonTungeln, Linda S., Schnackenberg, Laura K., Beger, Richard D., Moland, Carrie L., Han, Tao, Fuscoe, James C., Chang, Ching-Wei, Chen, James J., Su, Zhenqiang, Fan, Xiao-hui, Tong, Weida, Booth, Shelagh A., Balasubramanian, Raji, Courchesne, Paul L., Campbell, Jennifer M., Graber, Armin, Guo, Yu, Juhasz, Peter, Li, Tricia Y., Lynch, Moira D., Morel, Nicole M., Plasterer, Thomas N., Takach, Edward J., Zeng, Chenhui, Beland, Frederick A.

“…The Liver Toxicity Biomarker Study is a systems toxicology approach to discover biomarkers that are indicative of a drug’s potential to cause human…”
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The Liver Toxicity Biomarker Study: Phase I Design and Preliminary Results by Mcburney, Robert N., Hines, Wade M, Von Tungeln, Linda S., Schnackenberg, Laura K., Beger, Richard D., Moland, Carrie L., Tao Han, Fuscoe, James C., Chang, Ching-Wei, Chen, James J., Zhenqiang Su, Fan, Xiao-Hui, WEIDA TONG, Booth, Shelagh A., Balasubramanian, Raji, Courchesne, Paul L., Campbell, Jennifer M., Graber, Armin, YU GUO, Juhasz, Peter J., Li, Tricin Y., Lynch, Moira D., Morel, Nicole M., Plasterer, Thomas N., Takach, Edward J., CHENHUI ZENG, Beland, Frederick A.

“…Drug-induced liver injury (DILI) is the primary adverse event that results in withdrawal of drugs from the market and a frequent reason for the failure of drug…”
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Correlation network analysis for data integration and biomarker selection by Adourian, Aram, Jennings, Ezra, Balasubramanian, Raji, Hines, Wade M, Damian, Doris, Plasterer, Thomas N, Clish, Clary B, Stroobant, Paul, McBurney, Robert, Verheij, Elwin R, Bobeldijk, Ivana, van der Greef, Jan, Lindberg, Johan, Kenne, Kerstin, Andersson, Ulf, Hellmold, Heike, Nilsson, Kerstin, Salter, Hugh, Schuppe-Koistinen, Ina

“…High-throughput biomolecular profiling techniques such as transcriptomics, proteomics and metabolomics are increasingly being used in in vivo studies to…”
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Sensitivity and mass accuracy for proteins analyzed directly from polyacrylamide gels: implications for proteome mapping by Ogorzalek Loo, R R, Mitchell, C, Stevenson, T I, Martin, S A, Hines, W M, Juhasz, P, Patterson, D H, Peltier, J M, Loo, J A, Andrews, P C

“…Matrix-assisted laser desorption ionization (MALDI) mass spectra have been obtained directly from thin-layer isoelectric focusing (IEF) gels with as little as…”
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Accurate mass measurements using MALDI-TOF with delayed extraction by Takach, E J, Hines, W M, Patterson, D H, Juhasz, P, Falick, A M, Vestal, M L, Martin, S A

“…Matrix-assisted laser desorption ionization time-of-flight (MALDI-TOF) mass spectrometry is now an essential tool in biopolymer analysis. Sensitivity and mass…”
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Primary structures for a mammalian cellular and serum copper amine oxidase by MU, D, MEDZIHRADSZKY, K. F, ADAMS, G. W, MAYER, P, HINES, W. M, BURLINGAME, A. L, SMITH, A. J, CAI, D, KLINMAN, J. P

“…The 6-hydroxydopa quinone-containing active site peptide from bovine serum amine oxidase has been found to be highly homologous to a segment of a cloned human…”
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Pattern-based algorithm for peptide sequencing from tandem high energy collision-induced dissociation mass spectra by Hines, Wade M., Falick, Arnold M., Burlingame, Alma L., Gibson, Bradford W.

“…A new strategy is reported for extracting complete and partial sequence information from collision-induced dissociation (CID) spectra of peptides. CID spectra…”
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The sequence and reactive site of ecotin. A general inhibitor of pancreatic serine proteases from Escherichia coli by McGrath, M E, Hines, W M, Sakanari, J A, Fletterick, R J, Craik, C S

“…Ecotin, a serine protease inhibitor found in the periplasm of Escherichia coli, is unusual in its ability to inhibit chymotrypsin, trypsin, and elastase. To…”
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Mass spectrometric characterization of a series of adenosylated peptides acting as bisubstrate analogs of protein kinases by Gibson, Bradford W., Medzihradszky, Denes, Hines, Wade M., Auriola, Seppo, Kenyon, George L.

“…We are currently developing strategies to synthesize bisubstrate analogs as potential inhibitors of serine and tyrosine protein kinases; several such analogs…”
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Protein identification and protein characterization by high-performance time-of-flight mass spectrometry by Hines, W M, Parker, K, Peltier, J, Patterson, D H, Vestal, M L, Martin, S A

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