Search Results - "Hinds, Thomas R."

Crystal structure of the plant dual-affinity nitrate transporter NRT1.1 by Sun, Ji, Bankston, John R., Payandeh, Jian, Hinds, Thomas R., Zagotta, William N., Zheng, Ning

“…Nitrate is a primary nutrient for plant growth, but its levels in soil can fluctuate by several orders of magnitude. Previous studies have identified…”
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Structural basis of salicylic acid perception by Arabidopsis NPR proteins by Wang, Wei, Withers, John, Li, Heng, Zwack, Paul J., Rusnac, Domnița-Valeria, Shi, Hui, Liu, Lijing, Yan, Shunping, Hinds, Thomas R., Guttman, Mikelos, Dong, Xinnian, Zheng, Ning

“…Salicylic acid (SA) is a plant hormone that is critical for resistance to pathogens 1 – 3 . The NPR proteins have previously been identified as SA receptors 4…”
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Jasmonate perception by inositol-phosphate-potentiated COI1-JAZ co-receptor by Zheng, Ning, Sheard, Laura B, Tan, Xu, Mao, Haibin, Withers, John, Ben-Nissan, Gili, Hinds, Thomas R, Kobayashi, Yuichi, Hsu, Fong-Fu, Sharon, Michal, Browse, John, He, Sheng Yang, Rizo, Josep, Howe, Gregg A

“…Jasmonates are a family of plant hormones that regulate plant growth, development and responses to stress. The F-box protein CORONATINE INSENSITIVE 1 (COI1)…”
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Recognition of the iso-ADP-ribose moiety in poly(ADP-ribose) by WWE domains suggests a general mechanism for poly(ADP-ribosyl)ation-dependent ubiquitination by Wang, Zhizhi, Michaud, Gregory A, Cheng, Zhihong, Zhang, Yue, Hinds, Thomas R, Fan, Erkang, Cong, Feng, Xu, Wenqing

“…Protein poly(ADP-ribosyl)ation and ubiquitination are two key post-translational modifications regulating many biological processes. Through crystallographic…”
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Structure of an Inner Membrane Protein Required for PhoPQ-Regulated Increases in Outer Membrane Cardiolipin by Fan, Junping, Petersen, Erik M, Hinds, Thomas R, Zheng, Ning, Miller, Samuel I

“…The subsp. serovar Typhimurium PhoPQ two-component system is activated within the intracellular phagosome environment, where it promotes remodeling of the…”
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Allosteric Activation of Ubiquitin-Specific Proteases by β-Propeller Proteins UAF1 and WDR20 by Li, Heng, Lim, Kah Suan, Kim, Hyungjin, Hinds, Thomas R., Jo, Ukhyun, Mao, Haibin, Weller, Caroline E., Sun, Ji, Chatterjee, Champak, D’Andrea, Alan D., Zheng, Ning

“…Ubiquitin-specific proteases (USPs) constitute the largest family of deubiquitinating enzymes, whose catalytic competency is often modulated by their binding…”
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Crystal structure of a TAF1-TAF7 complex in human transcription factor IID reveals a promoter binding module by Wang, Hui, Curran, Elizabeth C, Hinds, Thomas R, Wang, Edith H, Zheng, Ning

“…The general transcription factor IID (TFIID) initiates RNA polymerase II-mediated eukaryotic transcription by nucleating pre-initiation complex formation at…”
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Rate Motifs Tune Auxin/Indole-3-Acetic Acid Degradation Dynamics by Moss, Britney L., Mao, Haibin, Guseman, Jessica M., Hinds, Thomas R., Hellmuth, Antje, Kovenock, Marlies, Noorassa, Anisa, Lanctot, Amy, Villalobos, Luz Irina A. Calderón, Zheng, Ning, Nemhauser, Jennifer L.

“…Ubiquitin-mediated protein degradation is a common feature in diverse plant cell signaling pathways; however, the factors that control the dynamics of…”
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Glycated Albumin Triggers an Inflammatory Response in the Human Airway Epithelium and Causes an Increase in Ciliary Beat Frequency by Aitken, Moira L, Somayaji, Ranjani, Hinds, Thomas R, Pier, Maricela, Droguett, Karla, Rios, Mariana, Skerrett, Shawn J, Villalon, Manuel

“…The role of inflammation in airway epithelial cells and its regulation are important in several respiratory diseases. When disease is present, the barrier…”
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Structural plasticity of D3–D14 ubiquitin ligase in strigolactone signalling by Shabek, Nitzan, Ticchiarelli, Fabrizio, Mao, Haibin, Hinds, Thomas R., Leyser, Ottoline, Zheng, Ning

“…The strigolactones, a class of plant hormones, regulate many aspects of plant physiology. In the inhibition of shoot branching, the α/β hydrolase D14—which…”
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Recognition of the Diglycine C-End Degron by CRL2KLHDC2 Ubiquitin Ligase by Rusnac, Domniţa-Valeria, Lin, Hsiu-Chuan, Canzani, Daniele, Tien, Karena X., Hinds, Thomas R., Tsue, Ashley F., Bush, Matthew F., Yen, Hsueh-Chi S., Zheng, Ning

“…Aberrant proteins can be deleterious to cells and are cleared by the ubiquitin-proteasome system. A group of C-end degrons that are recognized by specific…”
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The NSP14/NSP10 RNA repair complex as a Pan-coronavirus therapeutic target by Rona, Gergely, Zeke, Andras, Miwatani-Minter, Bearach, de Vries, Maren, Kaur, Ramanjit, Schinlever, Austin, Garcia, Sheena Faye, Goldberg, Hailey V., Wang, Hui, Hinds, Thomas R., Bailly, Fabrice, Zheng, Ning, Cotelle, Philippe, Desmaële, Didier, Landau, Nathaniel R., Dittmann, Meike, Pagano, Michele

“…The risk of zoonotic coronavirus spillover into the human population, as highlighted by the SARS-CoV-2 pandemic, demands the development of pan-coronavirus…”
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Characterization of a novel cAMP-binding, cAMP-specific cyclic nucleotide phosphodiesterase (TcrPDEB1) from Trypanosoma cruzi by Díaz-Benjumea, Rocío, Laxman, Sunil, Hinds, Thomas R, Beavo, Joseph A, Rascón, Ana

“…Trypanosoma cruzi, the causative agent of Chagas disease, encodes a number of different cAMP-specific PDE (phosphodiesterase) families. Here we report the…”
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Molecular Determinants of cGMP Binding to Chicken Cone Photoreceptor Phosphodiesterase by Huang, Daming, Hinds, Thomas R, Martinez, Sergio E, Doneanu, Catalin, Beavo, Joseph A

“…Structural studies on photoreceptor phosphodiesterases type 6 (PDE6s) have been hampered by an inability to express and purify substantial amounts of enzyme…”
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Zinc knuckle of TAF1 is a DNA binding module critical for TFIID promoter occupancy by Curran, Elizabeth C., Wang, Hui, Hinds, Thomas R., Zheng, Ning, Wang, Edith H.

“…The general transcription factor IID (TFIID) is the first component of the preinitiation complex (PIC) to bind the core promoter of RNA polymerase II…”
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Crystal Structure of a β-Catenin/BCL9/Tcf4 Complex by Sampietro, James, Dahlberg, Caroline L., Cho, Uhn Soo, Hinds, Thomas R., Kimelman, David, Xu, Wenqing

“…The canonical Wnt pathway plays critical roles in embryonic development, stem cell growth, and tumorigenesis. Stimulation of the Wnt pathway leads to the…”
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Cyclic nucleotide analogs as probes of signaling pathways by Hinds, Thomas R, Bos, Johannes L, Butt, Elke, Rehmann, Holger, Beavo, Joseph A, Rybalkin, Sergei D, Schwede, Frank, Christensen, Anne E, Tang, Xiao-Bo, Poppe, Heiko, Genieser, Hans-Gottfried, Doskeland, Stein O

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Scribble co-operatively binds multiple α1D-adrenergic receptor C-terminal PDZ ligands by Janezic, Eric M., Harris, Dorathy-Ann, Dinh, Diana, Lee, Kyung-Soon, Stewart, Aaron, Hinds, Thomas R., Hsu, Peter L., Zheng, Ning, Hague, Chris

“…Many G protein-coupled receptors (GPCRs) are organized as dynamic macromolecular complexes in human cells. Unraveling the structural determinants of unique…”
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Kaempferia parviflora, a plant used in traditional medicine to enhance sexual performance contains large amounts of low affinity PDE5 inhibitors by Temkitthawon, Prapapan, Hinds, Thomas R., Beavo, Joseph A., Viyoch, Jarupa, Suwanborirux, Khanit, Pongamornkul, Wittaya, Sawasdee, Pattara, Ingkaninan, Kornkanok

“…A number of medicinal plants are used in traditional medicine to treat erectile dysfunction. Since cyclic nucleotide PDEs inhibitors underlie several current…”
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The Third 20 Amino Acid Repeat Is the Tightest Binding Site of APC for β-Catenin by Liu, Jing, Xing, Yi, Hinds, Thomas R., Zheng, Jie, Xu, Wenqing

“…Adenomatous polyposis coli (APC) plays a critical role in the Wnt signaling pathway by tightly regulating β-catenin turnover and localization. The central…”
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