Search Results - "Hinds, Charles"

Genomic landscape of the individual host response and outcomes in sepsis: a prospective cohort study by Davenport, Emma E, DPhil, Burnham, Katie L, MGen, Radhakrishnan, Jayachandran, DPhil, Humburg, Peter, PhD, Hutton, Paula, PG Cert, Mills, Tara C, DPhil, Rautanen, Anna, PhD, Gordon, Anthony C, MD, Garrard, Christopher, DPhil, Hill, Adrian V S, Prof, Hinds, Charles J, Prof, Knight, Julian C, Prof

“…Summary Background Effective targeted therapy for sepsis requires an understanding of the heterogeneity in the individual host response to infection. We…”
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Neutrophils and emergency granulopoiesis drive immune suppression and an extreme response endotype during sepsis by Kwok, Andrew J., Allcock, Alice, Ferreira, Ricardo C., Cano-Gamez, Eddie, Smee, Madeleine, Burnham, Katie L., Zurke, Yasemin-Xiomara, McKechnie, Stuart, Mentzer, Alexander J., Monaco, Claudia, Udalova, Irina A., Hinds, Charles J., Todd, John A., Davenport, Emma E., Knight, Julian C.

“…Sepsis arises from diverse and incompletely understood dysregulated host response processes following infection that leads to life-threatening organ…”
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Transcriptomic Signatures in Sepsis and a Differential Response to Steroids. From the VANISH Randomized Trial by Antcliffe, David B, Burnham, Katie L, Al-Beidh, Farah, Santhakumaran, Shalini, Brett, Stephen J, Hinds, Charles J, Ashby, Deborah, Knight, Julian C, Gordon, Anthony C

“…There remains uncertainty about the role of corticosteroids in sepsis with clear beneficial effects on shock duration, but conflicting survival effects. Two…”
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Shared and Distinct Aspects of the Sepsis Transcriptomic Response to Fecal Peritonitis and Pneumonia by Burnham, Katie L, Davenport, Emma E, Radhakrishnan, Jayachandran, Humburg, Peter, Gordon, Anthony C, Hutton, Paula, Svoren-Jabalera, Eduardo, Garrard, Christopher, Hill, Adrian V S, Hinds, Charles J, Knight, Julian C

“…Heterogeneity in the septic response has hindered efforts to understand pathophysiology and develop targeted therapies. Source of infection, with different…”
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Patients with community acquired pneumonia admitted to European intensive care units: an epidemiological survey of the GenOSept cohort by Walden, Andrew P, Clarke, Geraldine M, McKechnie, Stuart, Hutton, Paula, Gordon, Anthony C, Rello, Jordi, Chiche, Jean-Daniel, Stueber, Frank, Garrard, Christopher S, Hinds, Charles J

“…Community acquired pneumonia (CAP) is the most common infectious reason for admission to the Intensive Care Unit (ICU). The GenOSept study was designed to…”
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The effect of increasing doses of norepinephrine on tissue oxygenation and microvascular flow in patients with septic shock by Jhanji, Shaman, Stirling, Sarah, Patel, Nakul, Hinds, Charles J, Pearse, Rupert M

“…OBJECTIVE:To investigate the effect of escalating doses of norepinephrine, aimed at achieving incremental increases in mean arterial pressure (MAP), on…”
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Classification of patients with sepsis according to blood genomic endotype: a prospective cohort study by Scicluna, Brendon P, van Vught, Lonneke A, Zwinderman, Aeilko H, Wiewel, Maryse A, Davenport, Emma E, Burnham, Katie L, Nürnberg, Peter, Schultz, Marcus J, Horn, Janneke, Cremer, Olaf L, Bonten, Marc J, Hinds, Charles J, Wong, Hector R, Knight, Julian C, van der Poll, Tom, de Beer, Friso M., Bos, Lieuwe D.J., Frencken, Jos F., Koster-Brouwer, Maria E., van de Groep, Kirsten, Verboom, Diana M., Glas, Gerie J., van Hooijdonk, Roosmarijn T.M., Hoogendijk, Arie J., Huson, Mischa A., Klouwenberg, Peter M. Klein, Ong, David S.Y., Schouten, Laura R.A., Straat, Marleen, Witteveen, Esther, Wieske, Luuk

“…Host responses during sepsis are highly heterogeneous, which hampers the identification of patients at high risk of mortality and their selection for targeted…”
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Post-operative immune suppression is mediated via reversible, Interleukin-10 dependent pathways in circulating monocytes following major abdominal surgery by Torrance, Hew D T, Longbottom, E Rebecca, Vivian, Mark E, Lalabekyan, Bagrat, Abbott, Tom E F, Ackland, Gareth L, Hinds, Charles J, Pearse, Rupert M, O'Dwyer, Michael J

“…Post-operative infections occur frequently following major surgery. The magnitude of the post-operative immune response is associated with an increased risk of…”
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Haemodynamic optimisation improves tissue microvascular flow and oxygenation after major surgery: a randomised controlled trial by Jhanji, Shaman, Vivian-Smith, Amanda, Lucena-Amaro, Susana, Watson, David, Hinds, Charles J, Pearse, Rupert M

“…Post-operative outcomes may be improved by the use of flow related end-points for intra-venous fluid and/or low dose inotropic therapy. The mechanisms…”
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Features of Postoperative Immune Suppression Are Reversible With Interferon Gamma and Independent of Interleukin-6 Pathways by Longbottom, E Rebecca, Torrance, Hew D T, Owen, Helen C, Fragkou, Paraskevi C, Hinds, Charles J, Pearse, Rupert M, O'Dwyer, Michael J

“…The aim of this study was to evaluate the role of interleukin (IL)-6 pathways in postoperative immune suppression and to assess the reversibility of this…”
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Patient stratification using plasma cytokines and their regulators in sepsis: relationship to outcomes, treatment effect and leucocyte transcriptomic subphenotypes by Antcliffe, David Benjamin, Mi, Yuxin, Santhakumaran, Shalini, Burnham, Katie L, Prevost, A Toby, Ward, Josie K, Marshall, Timothy J, Bradley, Claire, Al-Beidh, Farah, Hutton, Paula, McKechnie, Stuart, Davenport, Emma E, Hinds, Charles J, O'Kane, Cecilia M, McAuley, Daniel Francis, Shankar-Hari, Manu, Gordon, Anthony C, Knight, Julian C

“…Heterogeneity of the host response within sepsis, acute respiratory distress syndrome (ARDS) and more widely critical illness, limits discovery and targeting…”
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Microparticle alpha‐2‐macroglobulin enhances pro‐resolving responses and promotes survival in sepsis by Dalli, Jesmond, Norling, Lucy V, Montero‐Melendez, Trinidad, Canova, Donata Federici, Lashin, Hazem, Pavlov, Anton M, Sukhorukov, Gleb B, Hinds, Charles J, Perretti, Mauro

“…Incorporation of locally produced signaling molecules into cell‐derived vesicles may serve as an endogenous mediator delivery system. We recently reported that…”
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Lipoproteins in inflammation and sepsis. I. Basic science by Murch, Oliver, Collin, Marika, Hinds, Charles J, Thiemermann, Christoph

“…High-density lipoproteins (HDL) have been shown to bind and neutralize lipopolysaccharide (LPS) and are regarded as possible therapeutic agents for sepsis and…”
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A Transcriptomic Approach to Understand Patient Susceptibility to Pneumonia After Abdominal Surgery by Torrance, Hew D, Zhang, Ping, Longbottom, E Rebecca, Mi, Yuxin, Whalley, Justin P, Allcock, Alice, Kwok, Andrew J, Cano-Gamez, Eddie, Geoghegan, Cyndi G, Burnham, Katie L, Antcliffe, David B, Davenport, Emma E, Pearse, Rupert M, O’Dwyer, Michael J, Hinds, Charles J, Knight, Julian C, Gordon, Anthony C

“…To describe immune pathways and gene networks altered following major abdominal surgery and to identify transcriptomic patterns associated with postoperative…”
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Perioperative blood transfusion is associated with a gene transcription profile characteristic of immunosuppression: a prospective cohort study by Fragkou, Paraskevi C, Torrance, Hew D, Pearse, Rupert M, Ackland, Gareth L, Prowle, John R, Owen, Helen C, Hinds, Charles J, O'Dwyer, Michael J

“…Blood transfusion in the perioperative period has frequently been associated with an excess of nosocomial infections. Whilst transfused whole blood induces…”
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Microvesicle Subsets in Sepsis Due to Community Acquired Pneumonia Compared to Faecal Peritonitis by Lashin, Hazem M.S, Nadkarni, Suchita, Oggero, Silvia, Jones, Hefin R, Knight, Julian C, Hinds, Charles J, Perretti, Mauro

“…RATIONALE:Microvesicles (MV) act as a nonsoluble means of intercellular communication, with effector roles in disease pathogenesis and potentially as…”
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Epstein-Barr virus reactivation in sepsis due to community-acquired pneumonia is associated with increased morbidity and an immunosuppressed host transcriptomic endotype by Goh, Cyndi, Burnham, Katie L., Ansari, M. Azim, de Cesare, Mariateresa, Golubchik, Tanya, Hutton, Paula, Overend, Lauren E., Davenport, Emma E., Hinds, Charles J., Bowden, Rory, Knight, Julian C.

“…Epstein-Barr virus (EBV) reactivation is common in sepsis patients but the extent and nature of this remains unresolved. We sought to determine the incidence…”
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High-throughput mass spectrometry maps the sepsis plasma proteome and differences in patient response by Mi, Yuxin, Burnham, Katie L, Charles, Philip D, Heilig, Raphael, Vendrell, Iolanda, Whalley, Justin, Torrance, Hew D, Antcliffe, David B, May, Shaun M, Neville, Matt J, Berridge, Georgina, Hutton, Paula, Geoghegan, Cyndi G, Radhakrishnan, Jayachandran, Nesvizhskii, Alexey I, Yu, Fengchao, Davenport, Emma E, McKechnie, Stuart, Davies, Roger, O'Callaghan, David J P, Patel, Parind, Del Arroyo, Ana G, Karpe, Fredrik, Gordon, Anthony C, Ackland, Gareth L, Hinds, Charles J, Fischer, Roman, Knight, Julian C

“…Sepsis, the dysregulated host response to infection causing life-threatening organ dysfunction, is a global health challenge requiring better understanding of…”
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Association Between Gene Expression Biomarkers of Immunosuppression and Blood Transfusion in Severely Injured Polytrauma Patients by Torrance, Hew DT, Brohi, Karim, Pearse, Rupert M, Mein, Charles A, Wozniak, Eva, Prowle, John R, Hinds, Charles J, OʼDwyer, Michael J

“…OBJECTIVE:To explore the hypothesis that blood transfusion contributes to an immunosuppressed phenotype in severely injured patients. BACKGROUND:Despite trauma…”
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Response to Schöneweck et al.: Common genomic variation in the FER gene: useful to stratify patients with sepsis due to pneumonia? by Rautanen, Anna, Chapman, Stephen J., Hinds, Charles J.

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