Search Results - "Hindley, James P"

Magnitude of venous or capillary blood-derived SARS-CoV-2-specific T cell response determines COVID-19 immunity by Scurr, Martin J., Lippiatt, George, Capitani, Lorenzo, Bentley, Kirsten, Lauder, Sarah N., Smart, Kathryn, Somerville, Michelle S., Rees, Tara, Stanton, Richard J., Gallimore, Awen, Hindley, James P., Godkin, Andrew

“…T cells specific for SARS-CoV-2 are thought to protect against infection and development of COVID-19, but direct evidence for this is lacking. Here, we…”
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Interleukin‐6 limits influenza‐induced inflammation and protects against fatal lung pathology by Lauder, Sarah N., Jones, Emma, Smart, Kathryn, Bloom, Anja, Williams, Anwen S., Hindley, James P., Ondondo, Beatrice, Taylor, Philip R., Clement, Mathew, Fielding, Ceri, Godkin, Andrew J., Jones, Simon A., Gallimore, Awen M.

“…Balancing the generation of immune responses capable of controlling virus replication with those causing immunopathology is critical for the survival of the…”
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Are current analytical methods suitable to verify VITAL® 2.0/3.0 allergen reference doses for EU allergens in foods? by Holzhauser, Thomas, Johnson, Philip, Hindley, James P., O'Connor, Gavin, Chan, Chun-Han, Costa, Joana, Fæste, Christiane K., Hirst, Barbara J., Lambertini, Francesca, Miani, Michela, Robert, Marie-Claude, Röder, Martin, Ronsmans, Stefan, Bugyi, Zsuzsanna, Tömösközi, Sándor, Flanagan, Simon D.

“…Food allergy affects up to 6% of Europeans. Allergen identification is important for the risk assessment and management of the inadvertent presence of…”
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Quantifying Exposure to Food Allergens From Household Dust by Hindley, James P., Chapman, Martin D., Bermingham, Max, Alvares, Izabel

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Bos d 11 in baked milk poses a risk for adverse reactions in milk‐allergic patients by Hindley, James P., Oliver, Maria A., Thorpe, Cathy, Cullinane, Angharad, Wuenschmann, Sabina, Chapman, Martin D.

“…Background Patients are commonly challenged with foods containing baked milk, for example muffins, yet little is known about the specific allergen content of…”
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Treg Depletion Licenses T Cell-Driven HEV Neogenesis and Promotes Tumor Destruction by Colbeck, Emily J, Jones, Emma, Hindley, James P, Smart, Kathryn, Schulz, Ralph, Browne, Molly, Cutting, Scott, Williams, Anwen, Parry, Lee, Godkin, Andrew, Ware, Carl F, Ager, Ann, Gallimore, Awen

“…T-cell infiltration into tumors represents a critical bottleneck for immune-mediated control of cancer. We previously showed that this bottleneck can be…”
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Dose of allergens in a peanut snack (Bamba) associated with prevention of peanut allergy by Hindley, James P., Filep, Stephanie, Block, Denise S., King, Eva M., Chapman, Martin D.

“…To the Editor: A randomized trial of peanut consumption in infants at risk of food allergy, the Learning Early About Peanut Study (LEAP), recently showed that…”
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T-Cell Trafficking Facilitated by High Endothelial Venules Is Required for Tumor Control after Regulatory T-Cell Depletion by HINDLEY, James P, JONES, Emma, PRICE, David A, AGER, Ann, GODKIN, Andrew J, GALLIMORE, Awen M, SMART, Kathryn, BRIDGEMAN, Hayley, LAUDER, Sarah N, ONDONDO, Beatrice, CUTTING, Scott, LADELL, Kristin, WYNN, Katherine K, WITHERS, David

“…The evolution of immune blockades in tumors limits successful antitumor immunity, but the mechanisms underlying this process are not fully understood…”
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Comparative Analysis Of Specific Allergen Levels In Baked Milk Products by Hindley, James P., Cullinane, Angharad, Chapman, Martin D., Oliver, Maria A.

“…The aim was to compare the levels of major milk allergens in uncooked and baked milk containing foods, including recipes used for making oral food challenge…”
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Analysis of the T-Cell Receptor Repertoires of Tumor-Infiltrating Conventional and Regulatory T Cells Reveals No Evidence for Conversion in Carcinogen-Induced Tumors by HINDLEY, James P, FERREIRA, Cristina, DYSON, Julian, GALLIMORE, Awen, JONES, Emma, LAUDER, Sarah N, LADELL, Kristin, WYNN, Katherine K, BETTS, Gareth J, SINGH, Yogesh, PRICE, David A, GODKIN, Andrew J

“…A significant enrichment of CD4(+)Foxp3(+) T cells (regulatory T cells, Treg) is frequently observed in murine and human carcinomas. As Tregs can limit…”
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Immune Remodeling of the Extracellular Matrix Drives Loss of Cancer Stem Cells and Tumor Rejection by Pires, Ana, Greenshields-Watson, Alexander, Jones, Emma, Smart, Kathryn, Lauder, Sarah N, Somerville, Michelle, Milutinovic, Stefan, Kendrick, Howard, Hindley, James P, French, Rhiannon, Smalley, Matthew J, Watkins, William J, Andrews, Robert, Godkin, Andrew, Gallimore, Awen

“…The nature of the tumor microenvironment (TME) influences the ability of tumor-specific T cells to control tumor growth. In this study, we performed an…”
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Modification of the carboxy-terminal flanking region of a universal influenza epitope alters CD4+ T-cell repertoire selection by Cole, David K., Gallagher, Kathleen, Lemercier, Brigitte, Holland, Christopher J., Junaid, Sayed, Hindley, James P., Wynn, Katherine K., Gostick, Emma, Sewell, Andrew K., Gallimore, Awen M., Ladell, Kristin, Price, David A., Gougeon, Marie-Lise, Godkin, Andrew

“…Human CD4 + αβ T cells are activated via T-cell receptor recognition of peptide epitopes presented by major histocompatibility complex (MHC) class II (MHC-II)…”
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Eliminating roles for T-bet and IL-2 but revealing superior activation and proliferation as mechanisms underpinning dominance of regulatory T cells in tumors by Colbeck, Emily J, Hindley, James P, Smart, Kathryn, Jones, Emma, Bloom, Anja, Bridgeman, Hayley, McPherson, Rhoanne C, Turner, Darryl G, Ladell, Kristin, Price, David A, O'Connor, Richard A, Anderton, Stephen M, Godkin, Andrew J, Gallimore, Awen M

“…Foxp3(+) regulatory T cells (Tregs) are often highly enriched within the tumor-infiltrating T cell pool. Using a well-characterised model of carcinogen-induced…”
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Paracetamol reduces influenza-induced immunopathology in a mouse model of infection without compromising virus clearance or the generation of protective immunity by Lauder, Sarah N, Taylor, Philip R, Clark, Stephen R, Evans, Rhys L, Hindley, James P, Smart, Kathryn, Leach, Heather, Kidd, Emma J, Broadley, Kenneth J, Jones, Simon A, Wise, Matt P, Godkin, Andrew J, O'Donnell, Valerie, Gallimore, Awen M

“…Seasonal influenza A infection affects a significant cohort of the global population annually, resulting in considerable morbidity and mortality. Therapeutic…”
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Avidity of influenza‐specific memory CD8+ T‐cell populations decays over time compromising antiviral immunity by Humphreys, Ian R., Clement, Mathew, Marsden, Morgan, Ladell, Kristin, McLaren, James E., Smart, Kathryn, Hindley, James P., Bridgeman, Hayley M., van den Berg, Hugo A., Price, David A., Ager, Ann, Wooldridge, Linda, Godkin, Andrew, Gallimore, Awen M.

“…Decline of cell‐mediated immunity is often attributed to decaying T‐cell numbers and their distribution in peripheral organs. This study examined the…”
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Avidity of influenza‐specific memory CD 8 + T ‐cell populations decays over time compromising antiviral immunity by Humphreys, Ian R., Clement, Mathew, Marsden, Morgan, Ladell, Kristin, McLaren, James E., Smart, Kathryn, Hindley, James P., Bridgeman, Hayley M., van den Berg, Hugo A., Price, David A., Ager, Ann, Wooldridge, Linda, Godkin, Andrew, Gallimore, Awen M.

“…Decline of cell‐mediated immunity is often attributed to decaying T ‐cell numbers and their distribution in peripheral organs. This study examined the…”
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Avidity of influenza-specific memory CD 8 super(+) T -cell populations decays over time compromising antiviral immunity by Humphreys, Ian R, Clement, Mathew, Marsden, Morgan, Ladell, Kristin, McLaren, James E, Smart, Kathryn, Hindley, James P, Bridgeman, Hayley M, van den Berg, Hugo A, Price, David A, Ager, Ann, Wooldridge, Linda, Godkin, Andrew, Gallimore, Awen M

“…Decline of cell-mediated immunity is often attributed to decaying T -cell numbers and their distribution in peripheral organs. This study examined the…”
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