Search Results - "Hincal, A A"

Recent advances and future directions in amphiphilic cyclodextrin nanoparticles by Bilensoy, Erem, Hincal, A Atilla

“…Cyclodextrins are known to be promising excipients in the pharmaceutical industry, with their ability to include hydrophobic guest molecules masking the…”
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Safety and efficacy of amphiphilic beta-cyclodextrin nanoparticles for paclitaxel delivery by Bilensoy, Erem, Gürkaynak, Oya, Doğan, A Lale, Hincal, A Atilla

“…Paclitaxel is a potent anticancer agent with limited bioavailability due to side-effects associated with solubilizer used in its commercial formulation and the…”
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Development and Brain Delivery of Chitosan−PEG Nanoparticles Functionalized with the Monoclonal Antibody OX26 by Aktaş, Yeşim, Yemisci, Muge, Andrieux, Karine, Gürsoy, R. Neslihan, Alonso, Maria Jose, Fernandez-Megia, Eduardo, Novoa-Carballal, Ramón, Quiñoá, Emilio, Riguera, Ricardo, Sargon, Mustafa F, Çelik, H. Hamdi, Demir, Ayhan S, Hıncal, A. Atilla, Dalkara, Turgay, Çapan, Yılmaz, Couvreur, Patrick

“…The inhibition of the caspase-3 enzyme is reported to increase neuronal cell survival following cerebral ischemia. The peptide Z-DEVD-FMK is a specific caspase…”
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Tamoxifen citrate loaded amphiphilic β-cyclodextrin nanoparticles: In vitro characterization and cytotoxicity by Memisoglu-Bilensoy, Erem, Vural, Imran, Bochot, Amélie, Renoir, Jack Michel, Duchene, Dominique, Hıncal, A. Atilla

“…Nanospheres and nanocapsules of β-CDC6, amphiphilic β-cyclodextrin modified on the secondary face with 6C aliphatic esters, were prepared with…”
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The effects of lyophilization on the stability of liposomes containing 5-FU by Glavas-Dodov, M., Fredro-Kumbaradzi, E., Goracinova, K., Simonoska, M., Calis, S., Trajkovic-Jolevska, S., Hincal, A.A.

“…Multilamellar liposomes containing 5-fluorouracil (5-FU) were prepared by modified lipid film hydration method and were lyophilized with or without saccharose…”
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Drug permeation enhancement via buccal route: possibilities and limitations by SENEL, Sevda, HINCAL, A. Atilla

“…Over the last decade, there has been a particular interest in delivering drugs, especially peptides and proteins via the buccal route. It provides direct entry…”
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Hyaluronic acid coated poly-epsilon-caprolactone nanospheres deliver high concentrations of cyclosporine A into the cornea by Yenice, Irem, Mocan, Mehmet C, Palaska, Erhan, Bochot, Amélie, Bilensoy, Erem, Vural, Imran, Irkeç, Murat, Hincal, A Atilla

“…The objective of this study was to determine cyclosporine A (Cy A) levels in ocular tissues and fluids after topical administration of…”
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Mucoadhesive, thermosensitive, prolonged-release vaginal gel for clotrimazole: β-cyclodextrin complex by Bilensoy, Erem, Abdur Rouf, M., Vural, Imran, Šen, Murat, Atilla Hincal, A.

“…The purpose of this study was to achieve a better therapeutic efficacy and patient compliance in the treatment for vaginitis. Clotrimazole (1%) has been…”
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Development of nonsurfactant cyclodextrin nanoparticles loaded with anticancer drug paclitaxel by Bilensoy, Erem, Gürkaynak, Oya, Ertan, Mevlut, Sen, Murat, Hincal, A Atilla

“…In the current formulation of clinical use paclitaxel (PCX) is associated with solubilizers that may produce severe side effects. In this study, PCX was…”
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Sterile, injectable cyclodextrin nanoparticles: Effects of gamma irradiation and autoclaving by Memisoglu-Bilensoy, Erem, Hincal, A. Atilla

“…Sterility is required as stated by compendial requirements and registration authorities worldwide for an injectable drug carrier system. In this study,…”
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Enhancing effect of chitosan on peptide drug delivery across buccal mucosa by SENEL, S, KREMER, M. J, KAS, S, WERTZ, P. W, HINCAL, A. A, SQUIER, C. A

“…The buccal mucosa represents a potentially important topical route for delivery of peptide or protein drugs with some unique advantages such as the avoidance…”
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PEG-PE-based micelles co-loaded with paclitaxel and cyclosporine A or loaded with paclitaxel and targeted by anticancer antibody overcome drug resistance in cancer cells by Sarisozen, Can, Vural, Imran, Levchenko, Tatyana, Hincal, A Atilla, Torchilin, Vladimir P

“…The over-expression of the P-glycoprotein (P-gp) in cancer cells is one of the main reasons of the acquired Multidrug Resistance (MDR). Combined treatment of…”
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Long-circulating PEG-PE micelles co-loaded with paclitaxel and elacridar (GG918) overcome multidrug resistance by Sarisozen, Can, Vural, Imran, Levchenko, Tatyana, Hincal, A Atilla, Torchilin, Vladimir P

“…Overexpression of drug efflux pump P-gp is one of the major reasons to cause multidrug resistance (MDR). To overcome P-gp mediated MDR, modulators, so called…”
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Chitosan films and hydrogels of chlorhexidine gluconate for oral mucosal delivery by Şenel, S, İkinci, G, Kaş, S, Yousefi-Rad, A, Sargon, M.F, Hıncal, A.A

“…Topical delivery of antimicrobial agents is the most widely accepted approach aimed at prolonging active drug concentrations in the oral cavity. As most…”
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Effect of chitosan on a periodontal pathogen Porphyromonas gingivalis by İkinci, G, Şenel, S, Akıncıbay, H, Kaş, S, Erciş, S, Wilson, C.G, Hıncal, A.A

“…Local delivery systems of antimicrobial agents for treatment of the periodontal diseases received considerable attention during the past decade due to the…”
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Mucoadhesive, thermosensitive, prolonged-release vaginal gel for clotrimazole:beta-cyclodextrin complex by Bilensoy, Erem, Rouf, M Abdur, Vural, Imran, Sen, Murat, Hincal, A Atilla

“…The purpose of this study was to achieve a better therapeutic efficacy and patient compliance in the treatment for vaginitis. Clotrimazole (1%) has been…”
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Amphiphilic cyclodextrin nanoparticles by Varan, Gamze, Varan, Cem, Erdoğar, Nazlı, Hıncal, A. Atilla, Bilensoy, Erem

“…[Display omitted] Cyclodextrins are cyclic oligosaccharides obtained by enzymatic digestion of starch. The α-, β- and γ- cyclodextrins contain respectively 6,…”
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5-Fluorouracil encapsulated alginate beads for the treatment of breast cancer by Arıca, B, Çalış, S, Kaş, H.S, Sargon, M.F, Hıncal, A.A

“…Alginate beads containing 5-fluorouracil (5-FU) were prepared by the gelation of alginate with calcium cations. Alginate beads loaded with 5-FU were prepared…”
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Direct formation of nanospheres from amphiphilic β-cyclodextrin inclusion complexes by MEMISOZLU, Erem, BOCHOT, Amélie, ÖZALP, Meral, SEN, Murat, DUCHENE, Dominique, HINCAL, A. Atilla

“…The aim of this work was to develop and characterize a highly loaded nanoparticulate system based on amphiphilic beta-cyclodextrins (CDs) to facilitate the…”
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Formulation and in-vitro characterization of retinoic acid loaded poly (lactic-co-glycolic acid) microspheres by Çirpanli, Yasemin, ünlü, Nur en, Çali, Sema, At lla Hincal, A.

“…Poly (lactic-co-glycolic acid) (PLGA) microspheres containing all-trans retinoic acid (atRA) were prepared by emulsion solvent evaporation technique. PLGA…”
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