Search Results - "Hin Yan Tong, Amy"

Systematic Genetic Analysis with Ordered Arrays of Yeast Deletion Mutants by Amy Hin Yan Tong, Evangelista, Marie, Parsons, Ainslie B., Xu, Hong, Bader, Gary D., Pagé, Nicholas, Robinson, Mark, Raghibizadeh, Sasan, Christopher W. V. Hogue, Bussey, Howard, Andrews, Brenda, Tyers, Mike, Boone, Charles

“…In Saccharomyces cerevisiae, more than 80% of the ∼6200 predicted genes are nonessential, implying that the genome is buffered from the phenotypic consequences…”
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A Combined Experimental and Computational Strategy to Define Protein Interaction Networks for Peptide Recognition Modules by Amy Hin Yan Tong, Drees, Becky, Nardelli, Giuliano, Bader, Gary D., Brannetti, Barbara, Castagnoli, Luisa, Evangelista, Marie, Ferracuti, Silvia, Nelson, Bryce, Paoluzi, Serena, Quondam, Michele, Zucconi, Adriana, Christopher W. V. Hogue, Fields, Stanley, Boone, Charles, Cesareni, Gianni

“…Peptide recognition modules mediate many protein-protein interactions critical for the assembly of macromolecular complexes. Complete genome sequences have…”
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Analysis of the bacterial community in a laboratory-scale nitrification reactor and a wastewater treatment plant by 454-pyrosequencing by Ye, Lin, Shao, Ming-Fei, Zhang, Tong, Tong, Amy Hin Yan, Lok, Si

“…For full understanding of the microbial community in the wastewater treatment bioreactors, one of the feasible and effective ways is to investigate the massive…”
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Biased diversity metrics revealed by bacterial 16S pyrotags derived from different primer sets by Cai, Lin, Ye, Lin, Tong, Amy Hin Yan, Lok, Si, Zhang, Tong

“…In recent years, PCR-based pyrosequencing of 16S rRNA genes has continuously increased our understanding of complex microbial communities in various…”
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Ammonia-oxidizing archaea and ammonia-oxidizing bacteria in six full-scale wastewater treatment bioreactors by Zhang, Tong, Ye, Lin, Tong, Amy Hin Yan, Shao, Ming-Fei, Lok, Si

“…In this study, dideoxy sequencing and 454 high-throughput sequencing were used to analyze diversities of the ammonia monooxygenas e ( amo A) genes and the 16S…”
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Identifying human pre-mRNA cleavage and polyadenylation factors by genome-wide CRISPR screens using a dual fluorescence readthrough reporter by Ni, Zuyao, Ahmed, Nujhat, Nabeel-Shah, Syed, Guo, Xinghua, Pu, Shuye, Song, Jingwen, Marcon, Edyta, Burke, Giovanni L, Tong, Amy Hin Yan, Chan, Katherine, Ha, Kevin C H, Blencowe, Benjamin J, Moffat, Jason, Greenblatt, Jack F

“…Messenger RNA precursors (pre-mRNA) generally undergo 3' end processing by cleavage and polyadenylation (CPA), which is specified by a polyadenylation site…”
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Complete sequencing of pNDM-HK encoding NDM-1 carbapenemase from a multidrug-resistant Escherichia coli strain isolated in Hong Kong by Ho, Pak Leung, Lo, Wai U, Yeung, Man Kiu, Lin, Chi Ho, Chow, Kin Hung, Ang, Irene, Tong, Amy Hin Yan, Bao, Jessie Yun-Juan, Lok, Si, Lo, Janice Yee Chi

“…The emergence of plasmid-mediated carbapenemases, such as NDM-1 in Enterobacteriaceae is a major public health issue. Since they mediate resistance to…”
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Whole transcriptome analysis reveals differential gene expression profile reflecting macrophage polarization in response to influenza A H5N1 virus infection by Zhang, Na, Bao, Yun-Juan, Tong, Amy Hin-Yan, Zuyderduyn, Scott, Bader, Gary D, Malik Peiris, J S, Lok, Si, Lee, Suki Man-Yan

“…Avian influenza A H5N1 virus can cause lethal disease in humans. The virus can trigger severe pneumonia and lead to acute respiratory distress syndrome. Data…”
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Survival-based CRISPR genetic screens across a panel of permissive cell lines identify common and cell-specific SARS-CoV-2 host factors by Chan, Katherine, Farias, Adrian Granda, Lee, Hunsang, Guvenc, Furkan, Mero, Patricia, Brown, Kevin R., Ward, Henry, Billmann, Maximilian, Aulakh, Kamaldeep, Astori, Audrey, Haider, Shahan, Marcon, Edyta, Braunschweig, Ulrich, Pu, Shuye, Habsid, Andrea, Yan Tong, Amy Hin, Christie-Holmes, Natasha, Budylowski, Patrick, Ghalami, Ayoob, Mubareka, Samira, Maguire, Finlay, Banerjee, Arinjay, Mossman, Karen L., Greenblatt, Jack, Gray-Owen, Scott D., Raught, Brian, Blencowe, Benjamin J., Taipale, Mikko, Myers, Chad, Moffat, Jason

“…SARS-CoV-2 depends on host cell components for infection and replication. Identification of virus-host dependencies offers an effective way to elucidate…”
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The GTPase Arf1p and the ER to Golgi Cargo Receptor Erv14p Cooperate to Recruit the Golgin Rud3p to the Cis-Golgi by Gillingham, Alison K., Amy Hin Yan Tong, Boone, Charles, Munro, Sean

“…Rud3p is a coiled-coil protein of the yeast cis-Golgi. We find that Rud3p is localized to the Golgi via a COOH-terminal domain that is distantly related to the…”
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Pooled Lentiviral CRISPR-Cas9 Screens for Functional Genomics in Mammalian Cells by Aregger, Michael, Chandrashekhar, Megha, Tong, Amy Hin Yan, Chan, Katherine, Moffat, Jason

“…CRISPR-Cas9 technology provides a simple way to introduce targeted mutations into mammalian cells to induce loss-of-function phenotypes. The CRISPR-Cas9 system…”
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Recoding RNA editing of AZIN1 predisposes to hepatocellular carcinoma by Chen, Leilei, Li, Yan, Lin, Chi Ho, Chan, Tim Hon Man, Chow, Raymond Kwok Kei, Song, Yangyang, Liu, Ming, Yuan, Yun-Fei, Fu, Li, Kong, Kar Lok, Qi, Lihua, Li, Yan, Zhang, Na, Tong, Amy Hin Yan, Kwong, Dora Lai-Wan, Man, Kwan, Lo, Chung Mau, Lok, Si, Tenen, Daniel G, Guan, Xin-Yuan

“…RNA editing provides epigenetic diversity and is thought to be decreased in cancer. However, this report describes a phenomenon of increased RNA editing…”
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Evaluation and Design of Genome-Wide CRISPR/SpCas9 Knockout Screens by Hart, Traver, Tong, Amy Hin Yan, Chan, Katie, Van Leeuwen, Jolanda, Seetharaman, Ashwin, Aregger, Michael, Chandrashekhar, Megha, Hustedt, Nicole, Seth, Sahil, Noonan, Avery, Habsid, Andrea, Sizova, Olga, Nedyalkova, Lyudmila, Climie, Ryan, Tworzyanski, Leanne, Lawson, Keith, Sartori, Maria Augusta, Alibeh, Sabriyeh, Tieu, David, Masud, Sanna, Mero, Patricia, Weiss, Alexander, Brown, Kevin R, Usaj, Matej, Billmann, Maximilian, Rahman, Mahfuzur, Constanzo, Michael, Myers, Chad L, Andrews, Brenda J, Boone, Charles, Durocher, Daniel, Moffat, Jason

“…The adaptation of CRISPR/SpCas9 technology to mammalian cell lines is transforming the study of human functional genomics. Pooled libraries of CRISPR guide…”
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Ybp2 associates with the central kinetochore of Saccharomyces cerevisiae and mediates proper mitotic progression by Ohkuni, Kentaro, Abdulle, Rashid, Tong, Amy Hin Yan, Boone, Charles, Kitagawa, Katsumi

“…The spindle checkpoint ensures the accurate segregation of chromosomes by monitoring the status of kinetochore attachment to microtubules. Simultaneous…”
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Essential Gene Profiles for Human Pluripotent Stem Cells Identify Uncharacterized Genes and Substrate Dependencies by Mair, Barbara, Tomic, Jelena, Masud, Sanna N., Tonge, Peter, Weiss, Alexander, Usaj, Matej, Tong, Amy Hin Yan, Kwan, Jamie J., Brown, Kevin R., Titus, Emily, Atkins, Michael, Chan, Katherine S.K., Munsie, Lise, Habsid, Andrea, Han, Hong, Kennedy, Marion, Cohen, Brenda, Keller, Gordon, Moffat, Jason

“…Human pluripotent stem cells (hPSCs) provide an invaluable tool for modeling diseases and hold promise for regenerative medicine. For understanding…”
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N-terminal acetylation shields proteins from degradation and promotes age-dependent motility and longevity by Varland, Sylvia, Silva, Rui Duarte, Kjosås, Ine, Faustino, Alexandra, Bogaert, Annelies, Billmann, Maximilian, Boukhatmi, Hadi, Kellen, Barbara, Costanzo, Michael, Drazic, Adrian, Osberg, Camilla, Chan, Katherine, Zhang, Xiang, Tong, Amy Hin Yan, Andreazza, Simonetta, Lee, Juliette J., Nedyalkova, Lyudmila, Ušaj, Matej, Whitworth, Alexander J., Andrews, Brenda J., Moffat, Jason, Myers, Chad L., Gevaert, Kris, Boone, Charles, Martinho, Rui Gonçalo, Arnesen, Thomas

“…Most eukaryotic proteins are N-terminally acetylated, but the functional impact on a global scale has remained obscure. Using genome-wide CRISPR knockout…”
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Genome-wide, as opposed to local, antisilencing is mediated redundantly by the euchromatic factors Set1 and H2A.Z by Venkatasubrahmanyam, Shivkumar, Hwang, William W, Meneghini, Marc D, Tong, Amy Hin Yan, Madhani, Hiten D

“…In Saccharomyces cerevisiae, several nonessential mechanisms including histone variant H2A.Z deposition and transcription-associated histone H3 methylation…”
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Interactome-transcriptome analysis discovers signatures complementary to GWAS Loci of Type 2 Diabetes by Li, Jing-Woei, Lee, Heung-Man, Wang, Ying, Tong, Amy Hin-Yan, Yip, Kevin Y., Tsui, Stephen Kwok-Wing, Lok, Si, Ozaki, Risa, Luk, Andrea O, Kong, Alice P. S., So, Wing-Yee, Ma, Ronald C. W., Chan, Juliana C. N., Chan, Ting-Fung

“…Protein interactions play significant roles in complex diseases. We analyzed peripheral blood mononuclear cells (PBMC) transcriptome using a multi-method…”
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A network of multi-tasking proteins at the DNA replication fork preserves genome stability by Budd, Martin E, Tong, Amy Hin Yan, Polaczek, Piotr, Peng, Xiao, Boone, Charles, Campbell, Judith L

“…To elucidate the network that maintains high fidelity genome replication, we have introduced two conditional mutant alleles of DNA2, an essential DNA…”
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Mutations enabling displacement of tryptophan by 4-fluorotryptophan as a canonical amino acid of the genetic code by Yu, Allen Chi-Shing, Yim, Aldrin Kay-Yuen, Mat, Wai-Kin, Tong, Amy Hin-Yan, Lok, Si, Xue, Hong, Tsui, Stephen Kwok-Wing, Wong, J Tze-Fei, Chan, Ting-Fung

“…The 20 canonical amino acids of the genetic code have been invariant over 3 billion years of biological evolution. Although various aminoacyl-tRNA synthetases…”
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