Search Results - "Himmelstein, Matthew"

Inhalation and oral toxicokinetics of 6:2 FTOH and its metabolites in mammals by Russell, Mark H., Himmelstein, Matthew W., Buck, Robert C.

“…•Toxicokinetics of 6:2 FTOH and metabolites evaluated in rats and humans.•Single and repeated dose exposure studied in rats via inhalation and oral…”
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Metabolic Basis for Nonlinearity in 1,3-Dichloropropene Toxicokinetics and Use in Setting a Kinetically-derived Maximum Inhalation Exposure Concentration in Mice by Bartels, Michael J, Hackett, Michael J, Himmelstein, Matthew W, Green, John W, Walker, Carl, Terry, Claire, Rasoulpour, Reza, Challender, Mary, Yan, Zhongyu (June)

“…Abstract 1,3-Dichloropropene (1,3-D) showed a statistically increased incidence of bronchioloalveolar adenomas in male B6C3F1 mice at 60 ppm air concentration…”
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An in vitro approach for comparative interspecies metabolism of agrochemicals by Whalley, Paul M., Bartels, Michael, Bentley, Karin S., Corvaro, Marco, Funk, Dorothee, Himmelstein, Matthew W., Neumann, Birgit, Strupp, Christian, Zhang, Fagen, Mehta, Jyotigna

“…The metabolism and elimination of a xenobiotic has a direct bearing on its potential to cause toxicity in an organism. The confidence with which data from…”
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In Vitro Metabolism of 8-2 Fluorotelomer Alcohol: Interspecies Comparisons and Metabolic Pathway Refinement by Nabb, Diane L., Szostek, Bogdan, Himmelstein, Matthew W., Mawn, Michael P., Gargas, Michael L., Sweeney, Lisa M., Stadler, Judith C., Buck, Robert C., Fasano, William J.

“…The detection of perfluorinated organic compounds in the environment has generated interest in their biological fate. 8-2 Fluorotelomer alcohol (8-2 FTOH,…”
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Creating context for the use of DNA adduct data in cancer risk assessment: II. Overview of methods of identification and quantitation of DNA damage by Himmelstein, Matthew W., Boogaard, Peter J., Cadet, Jean, Farmer, Peter B., Kim, James H., Martin, Elizabeth A., Persaud, Rudranath, Shuker, David E.G.

“…The formation of deoxyribonucleic acid (DNA) adducts can have important and adverse consequences for cellular and whole organism function. Available methods…”
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Cross-species transcriptomic analysis of mouse and rat lung exposed to chloroprene by Thomas, Russell S, Himmelstein, Matthew W, Clewell, 3rd, Harvey J, Yang, Yuching, Healy, Eric, Black, Michael B, Andersen, Melvin E

“…β-Chloroprene (2-chloro-1,3-butadiene), a monomer used in the production of neoprene elastomers, is of regulatory interest due to the production of multiorgan…”
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8:2 fluorotelomer alcohol: A one-day nose-only inhalation toxicokinetic study in the Sprague-Dawley rat with application to risk assessment by Himmelstein, Matthew W, Serex, Tessa L, Buck, Robert C, Weinberg, Jeffrey T, Mawn, Michael P, Russell, Mark H

“…Highlights ► 8:2 FTOH inhalation exposure and metabolism were investigated in rats. ► The parent 8:2 FTOH showed rapid uptake and clearance from the plasma. ►…”
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An organizational approach for the assessment of DNA adduct data in risk assessment: case studies for aflatoxin B1, tamoxifen and vinyl chloride by Pottenger, Lynn H., Andrews, Larry S., Bachman, Ammie N., Boogaard, Peter J., Cadet, Jean, Embry, Michelle R., Farmer, Peter B., Himmelstein, Matthew W., Jarabek, Annie M., Martin, Elizabeth A., Mauthe, Robert J., Persaud, Rudranath, Preston, R. Julian, Schoeny, Rita, Skare, Julie, Swenberg, James A., Williams, Gary M., Zeiger, Errol, Zhang, Fagen, Kim, James H.

“…Abstract The framework analysis previously presented for using DNA adduct information in the risk assessment of chemical carcinogens was applied in a series of…”
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Kinetic modeling of β-chloroprene metabolism: Probabilistic in vitro–in vivo extrapolation of metabolism in the lung, liver and kidneys of mice, rats and humans by Yang, Yuching, Himmelstein, Matthew W., Clewell, Harvey J.

“…► Investigate the tissues/gender difference of in vitro CD metabolism in rodents and human. ► Demonstrate a probabilistic approach to integrate in vitro…”
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Comparative Metabolism of 1,2,3,3,3-Pentafluoropropene in Male and Female Mouse, Rat, Dog, and Human Liver Microsomes and Cytosol and Male Rat Hepatocytes via Oxidative Dehalogenation and Glutathione S-Conjugation Pathways by XING HAN, SZOSTEK, Bogdan, YANG, Ching-Hui, CHEATHAM, Steve F, MINGOIA, Robert T, NAB, Diane L, GANNON, Shawn A, HIMMELSTEIN, Matthew W, JEPSON, Gary W

“…In vitro metabolism of 1,2,3,3,3-pentafluoropropene (PFP) was investigated in the present study. PFP was metabolized via cytochrome P450-catalyzed oxidative…”
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Physiologically based Pharmacokinetic Modeling of Chloroethane Disposition in Mice, Rats, and Women by Gargas, Michael L., Sweeney, Lisa M., Himmelstein, Matthew W., Pottenger, Lynn H., Bus, James S., Holder, James W.

“…Chloroethane was observed in a chronic cancer bioassay to be a mouse-specific uterine carcinogen at a single high inhaled concentration (15,000 ppm). Although…”
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Development and validation of an assay for iodide in serum using ion chromatography with pulsed amperometric detection by Kaiser, Edward, Shaffer, Lydia, Flaherty, John M., Rohrer, Jeffrey S., Himmelstein, Matthew W.

“…We developed and validated an ion chromatography method to assay iodide in serum sampled from rats and rabbits that had been exposed to iodomethane…”
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Two-day inhalation toxicity study of methyl iodide in the rat by Himmelstein, Matthew W., Kegelman, Thomas A., DeLorme, Michael P., Everds, Nancy E., O'Connor, John C., Kemper, Raymond A., Nabb, Diane L., Mileson, Beth E., Bevan, Christopher

“…The effects of inhaled methyl iodide (MeI) on clinical pathology parameters, glutathione (GSH) tissue levels, serum thyroid hormone and inorganic iodide…”
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Kinetic Modeling of β-Chloroprene Metabolism: I. In vitro Rates in Liver and Lung Tissue Fractions from Mice, Rats, Hamsters, and Humans by Himmelstein, Matthew W., Carpenter, Steven C., Hinderliter, Paul M.

“…Beta-chloroprene (2-chloro-1,3-butadiene, CD) is carcinogenic by inhalation exposure to B6C3F1 mice and Fischer F344 rats but not to Wistar rats or Syrian…”
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The use of non-tumor data in cancer risk assessment: reflections on butadiene, vinyl chloride, and benzene by Albertini, Richard, Clewell, Harvey, Himmelstein, Matthew W, Morinello, Eric, Olin, Stephen, Preston, Julian, Scarano, Louis, Smith, Martyn T, Swenberg, James, Tice, Raymond, Travis, Curtis

“…The estimation and characterization of a cancer risk is grounded in the observation of tumors in humans and/or experimental animals. Increasingly, however,…”
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Kinetic Modeling of β-Chloroprene Metabolism: II. The Application of Physiologically Based Modeling for Cancer Dose Response Analysis by Himmelstein, Matthew W., Carpenter, Steven C., Evans, Marina V., Hinderliter, Paul M., Kenyon, Elaina M.

“…β-Chloroprene (2-chloro-1,3-butadiene; CD), which is used in the synthesis of polychloroprene, caused significant incidences of several tumor types in B6C3F1…”
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International Symposium on the Evaluation of Butadiene and Chloroprene Health Risks by Himmelstein, Matthew W., Baan, Robert A., Albertini, Richard J., Bird, Michael G., Lewis, R. Jeffrey

“…These proceedings represent nearly all the platform and poster presentations given during the International Symposium on Evaluation of Butadiene and…”
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Overview of the acute, subchronic, reproductive, developmental and genetic toxicology of β-chloroprene by Valentine, Rudolph, Himmelstein, Matthew W

“…β-Chloroprene (CD), the 2-chloro derivative of 1,3-butadiene, is used for the manufacture of the synthetic rubber, polychloroprene. Acute inhalation studies…”
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Development of a preliminary physiologically based toxicokinetic (PBTK) model for 1,3-butadiene risk assessment by Sweeney, Lisa M, Himmelstein, Matthew W, Gargas, Michael L

“…Potential health effects of human exposure to 1,3-butadiene (BD) are of concern due to the use of BD in industry and its low-level presence throughout the…”
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In vitro genotoxicity testing of (1-chloroethenyl)oxirane, a metabolite of β-chloroprene by Himmelstein, Matthew W, Lawrence Gladnick, N, Maria Donner, E, Snyder, Ronald D, Valentine, Rudolph

“…(1-Chloroethenyl)oxirane (CEO) is a metabolite of β-chloroprene (2-chloro-1,3-butadiene, CD). The purpose of this study was to evaluate the in vitro mutagenic…”
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