Search Results - "Himmelstein, K J"

Modification of in situ gelling behavior of carbopol solutions by hydroxypropyl methylcellulose by Kumar, S, Himmelstein, K J

“…Aqueous solutions of Carbopol [polyacrylic acid (PAA)] are low viscosity acidic solutions that transform into gels upon an increase in the pH and, therefore,…”
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In vivo properties of an in situ forming gel for parenteral delivery of macromolecular drugs by JOSHI, R, ARORA, V, DESJARDINS, J. P, ROBINSON, D, HIMMELSTEIN, K. J, IVERSEN, P. L

“…This study characterizes the in vivo properties of an in situ forming gel, comprising of IPC of water-soluble polymers, PMA and PEG, for sustained release of…”
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Controlled release of substituted benzoic and naphthoic acids using carbopol® gels : measurement of drug concentration profiles and correlation to release rate kinetics by FRENCH, D. L, HÄGLUND, B. O, HIMMELSTEIN, K. J, MAUGER, J. W

“…The objective of this study is to correlate drug release mechanism with measured drug concentration profiles in gel layers of Carbopol matrices containing…”
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In Vitro Properties of an In Situ Forming Gel for the Parenteral Delivery of Macromolecular Drugs by Joshi, Rajashree, Robinson, Dennis H., Himmelstein, Kenneth J.

“…The purpose of this research was to (i) formulate a solution of a water-insoluble interpolymeric complex (IPC) containing poly(methacrylic acid) (PMA), 15 kDa,…”
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Dissolution of ionizable drugs into unbuffered solution : a comprehensive model for mass transport and reaction in the rotating disk geometry by SOUTHARD, M. Z, GREEN, D. W, STELLA, V. J, HIMMELSTEIN, K. J

“…A model has been developed to describe the mass transport and reaction of ionizable compounds where mass transfer is caused by convection and diffusion from a…”
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Drug delivery from catalysed erodible polymeric matrices of poly(ortho ester)s by Shih, C, Higuchi, T, Himmelstein, K J

“…The incorporation of small amounts of acid anhydrides into hydrophobic poly(ortho ester)s can facilitate the erosion and drug release from delivery systems…”
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Experimental determinations of diffusion coefficients in dilute aqueous solution using the method of hydrodynamic stability by SOUTHARD, M. Z, DIAS, L. J, HIMMELSTEIN, K. J, STELLA, V. J

“…Diffusion coefficients were experimentally determined in dilute aqueous solution at 25 +/- 0.1 degrees C, ionic strength 0.5 M, using Taylor's method of…”
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Poly(ortho ester) biodegradable polymer systems by Heller, J, Himmelstein, K J

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An in situ gelling system for parenteral delivery by Haglund, Bert O., Joshi, Rajashree, Himmelstein, Kenneth J.

“…Polymer complexes formed by electrostatic interactions or hydrogen bonds between polymer strands can be utilized as a drug delivery system, as its ability to…”
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A review of the applications of physiologically based pharmacokinetic modeling by Himmelstein, K J, Lutz, R J

“…The physiological pharmacokinetic approach to the modeling of drug distribution is reviewed. These models allow extrapolation outside the range of data with…”
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Quantitative evaluation of topically applied pilocarpine in the precorneal area by Thombre, A G, Himmelstein, K J

“…The bioavailability of topically applied pilocarpine is poor due to various loss mechanisms that serve to lessen delivery of the drug to the aqueous humor…”
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Precorneal sampling techniques for ophthalmic gels by Ding, S, Chen, C C, Salome-Kesslak, R, Tang-Liu, D D, Himmelstein, K J

“…Drug-cornea contact time is a critical issue in ocular drug delivery. Existing methods for its experimental determination are developed mainly for eye drops…”
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In situ-forming gels for ophthalmic drug delivery by Kumar, S, Haglund, B O, Himmelstein, K J

“…Poor bioavailability of ophthalmic solutions caused by dilution and drainage from the eye can be overcome by using in situ-forming ophthalmic drug delivery…”
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Hydrolysis of some poly(ortho-ester)s in homogeneous solutions by Nguyen, T H, Shih, C, Himmelstein, K J, Higuchi, T

“…The hydrolysis of poly(ortho-ester)s and a monomeric model compound, 3,9-dibenzyloxy-3,9-diethyl-2,4,8,10-tetraoxaspiro[5,5]un decane, was carried out in…”
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Determination of steady state generation time distributions from labelled mitosis experimental data by Palsson, B, Himmelstein, K J

“…The proper application of detailed deterministic cell kinetic models depends on the way in which cells are assigned their generation times. A method is…”
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Dissolution of ionizable drugs in buffered and unbuffered solution by Himmelstein, K J

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Diffusion of phenol in the presence of a complexing agent, tetrahydrofuran by Dressman, J B, Himmelstein, K J, Higuchi, T

“…The effect of a complexing agent, tetrahydrofuran, on the diffusion of phenol across a stagnant fluid layer has been studied. At a given activity of free…”
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Simultaneous self-association and diffusion of phenol in isooctane by Dressman, J B, Himmelstein, K J, Higuchi, T

“…The impact of self-association on mass transport was studied. The model system chosen was the diffusion of phenol through an immobilized layer of isooctane. In…”
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Dissolution kinetics of phenylbutazone by Mooney, K G, Rodriguez-Gaxiola, M, Mintun, M, Himmelstein, K J, Stella, V J

“…This study investigated the possible effects of simultaneous, noninstantaneous, reversible chemical ionization of carbon acids on the dissolution of a typical…”
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Mathematical model for cyclocytidine pharmacokinetics by Himmelstein, K J, Gross, J F

“…The pharmacokinetics of the drug cyclocytidine in humans were modeled by using a physiological and anatomical approach. Each pertinent tissue is represented by…”
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