Search Results - "Himmelfarb, Jonathan"

The current and future landscape of dialysis by Himmelfarb, Jonathan, Vanholder, Raymond, Mehrotra, Rajnish, Tonelli, Marcello

“…The development of dialysis by early pioneers such as Willem Kolff and Belding Scribner set in motion several dramatic changes in the epidemiology, economics…”
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Acute Kidney Injury Episodes and Chronic Kidney Disease Risk in Diabetes Mellitus by Thakar, Charuhas V, Christianson, Annette, Himmelfarb, Jonathan, Leonard, Anthony C

“…Prior studies have examined long-term outcomes of a single acute kidney injury (AKI) event in hospitalized patients. We examined the effects of AKI episodes…”
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Kidney Disease and Increased Mortality Risk in Type 2 Diabetes by AFKARIAN, Maryam, SACHS, Michael C, KESTENBAUM, Bryan, HIRSCH, Irl B, TUTTLE, Katherine R, HIMMELFARB, Jonathan, DE BOER, Ian H

“…Type 2 diabetes associates with increased risk of mortality, but how kidney disease contributes to this mortality risk among individuals with type 2 diabetes…”
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A 3D Human Renal Cell Carcinoma-on-a-Chip for the Study of Tumor Angiogenesis by Miller, Chris P., Tsuchida, Connor, Zheng, Ying, Himmelfarb, Jonathan, Akilesh, Shreeram

“…Tractable human tissue-engineered 3D models of cancer that enable fine control of tumor growth, metabolism, and reciprocal interactions between different cell…”
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Advances in understanding ischemic acute kidney injury by Munshi, Raj, Hsu, Christine, Himmelfarb, Jonathan

“…Acute kidney injury (AKI) is independently associated with increased morbidity and mortality. Ischemia is the leading cause of AKI, and short of supportive…”
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High-Throughput Screening Enhances Kidney Organoid Differentiation from Human Pluripotent Stem Cells and Enables Automated Multidimensional Phenotyping by Czerniecki, Stefan M., Cruz, Nelly M., Harder, Jennifer L., Menon, Rajasree, Annis, James, Otto, Edgar A., Gulieva, Ramila E., Islas, Laura V., Kim, Yong Kyun, Tran, Linh M., Martins, Timothy J., Pippin, Jeffrey W., Fu, Hongxia, Kretzler, Matthias, Shankland, Stuart J., Himmelfarb, Jonathan, Moon, Randall T., Paragas, Neal, Freedman, Benjamin S.

“…Organoids derived from human pluripotent stem cells are a potentially powerful tool for high-throughput screening (HTS), but the complexity of organoid…”
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Effects of chronic kidney disease and uremia on hepatic drug metabolism and transport by Yeung, Catherine K, Shen, Danny D, Thummel, Kenneth E, Himmelfarb, Jonathan

“…The pharmacokinetics of non-renally cleared drugs in patients with chronic kidney disease is often unpredictable. Some of this variability may be due to…”
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Organoid cystogenesis reveals a critical role of microenvironment in human polycystic kidney disease by Cruz, Nelly M., Song, Xuewen, Czerniecki, Stefan M., Gulieva, Ramila E., Churchill, Angela J., Kim, Yong Kyun, Winston, Kosuke, Tran, Linh M., Diaz, Marco A., Fu, Hongxia, Finn, Laura S., Pei, York, Himmelfarb, Jonathan, Freedman, Benjamin S.

“…Tissue mimics are of great interest in understanding diseases. Here, organoids were developed that resemble polycystic kidney disease cysts and it was…”
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Prevention and treatment of protein energy wasting in chronic kidney disease patients: a consensus statement by the International Society of Renal Nutrition and Metabolism by Ikizler, T Alp, Cano, Noel J, Franch, Harold, Fouque, Denis, Himmelfarb, Jonathan, Kalantar-Zadeh, Kamyar, Kuhlmann, Martin K, Stenvinkel, Peter, TerWee, Pieter, Teta, Daniel, Wang, Angela Yee-Moon, Wanner, Christoph

“…Protein energy wasting (PEW) is common in patients with chronic kidney disease (CKD) and is associated with adverse clinical outcomes, especially in…”
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Biomarkers of inflammation and repair in kidney disease progression by Puthumana, Jeremy, Thiessen-Philbrook, Heather, Xu, Leyuan, Coca, Steven G, Garg, Amit X, Himmelfarb, Jonathan, Bhatraju, Pavan K, Ikizler, T Alp, Siew, Edward D, Ware, Lorraine B, Liu, Kathleen D, Go, Alan S, Kaufman, James S, Kimmel, Paul L, Chinchilli, Vernon M, Cantley, Lloyd G, Parikh, Chirag R

“…INTRODUCTIONAcute kidney injury and chronic kidney disease (CKD) are common in hospitalized patients. To inform clinical decision making, more accurate…”
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Development of a microphysiological model of human kidney proximal tubule function by Weber, Elijah J, Chapron, Alenka, Chapron, Brian D, Voellinger, Jenna L, Lidberg, Kevin A, Yeung, Catherine K, Wang, Zhican, Yamaura, Yoshiyuki, Hailey, Dale W, Neumann, Thomas, Shen, Danny D, Thummel, Kenneth E, Muczynski, Kimberly A, Himmelfarb, Jonathan, Kelly, Edward J

“…The kidney proximal tubule is the primary site in the nephron for excretion of waste products through a combination of active uptake and secretory processes…”
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GDF-15, Galectin 3, Soluble ST2, and Risk of Mortality and Cardiovascular Events in CKD by Tuegel, Courtney, Katz, Ronit, Alam, Mariam, Bhat, Zeenat, Bellovich, Keith, de Boer, Ian, Brosius, Frank, Gadegbeku, Crystal, Gipson, Debbie, Hawkins, Jennifer, Himmelfarb, Jonathan, Ju, Wenjun, Kestenbaum, Bryan, Kretzler, Matthias, Robinson-Cohen, Cassianne, Steigerwalt, Susan, Bansal, Nisha

“…Inflammation, cardiac remodeling, and fibrosis may explain in part the excess risk for cardiovascular disease (CVD) in patients with chronic kidney disease…”
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Association between Physical Performance and All-Cause Mortality in CKD by ROSHANRAVAN, Baback, ROBINSON-COHEN, Cassianne, SELIGER, Stephen, PATEL, Kushang V, AYERS, Ernest, LITTMAN, Alyson J, DE BOER, Ian H, IKIZLER, T. Alp, HIMMELFARB, Jonathan, KATZEL, Leslie I, KESTENBAUM, Bryan

“…In older adults, measurements of physical performance assess physical function and associate with mortality and disability. Muscle wasting and diminished…”
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Abundance of Drug Transporters in the Human Kidney Cortex as Quantified by Quantitative Targeted Proteomics by Prasad, Bhagwat, Johnson, Katherine, Billington, Sarah, Lee, Caroline, Chung, Git W, Brown, Colin D A, Kelly, Edward J, Himmelfarb, Jonathan, Unadkat, Jashvant D

“…Protein expression of renal uptake and efflux transporters was quantified by quantitative targeted proteomics using the surrogate peptide approach. Renal…”
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Maintenance Dialysis throughout the World in Years 1990 and 2010 by Thomas, Bernadette, Wulf, Sarah, Bikbov, Boris, Perico, Norberto, Cortinovis, Monica, Courville de Vaccaro, Karen, Flaxman, Abraham, Peterson, Hannah, Delossantos, Allyne, Haring, Diana, Mehrotra, Rajnish, Himmelfarb, Jonathan, Remuzzi, Giuseppe, Murray, Christopher, Naghavi, Mohsen

“…Rapidly rising global rates of chronic diseases portend a consequent rise in ESRD. Despite this, kidney disease is not included in the list of noncommunicable…”
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Growth Differentiation Factor-15 and Risk of CKD Progression by Nair, Viji, Robinson-Cohen, Cassianne, Smith, Michelle R, Bellovich, Keith A, Bhat, Zeenat Yousuf, Bobadilla, Maria, Brosius, Frank, de Boer, Ian H, Essioux, Laurent, Formentini, Ivan, Gadegbeku, Crystal A, Gipson, Debbie, Hawkins, Jennifer, Himmelfarb, Jonathan, Kestenbaum, Bryan, Kretzler, Matthias, Magnone, Maria Chiara, Perumal, Kalyani, Steigerwalt, Susan, Ju, Wenjun, Bansal, Nisha

“…Growth differentiation factor-15 (GDF-15) is a member of the TGF- cytokine superfamily that is widely expressed and may be induced in response to tissue…”
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Glucose absorption drives cystogenesis in a human organoid-on-chip model of polycystic kidney disease by Li, Sienna R., Gulieva, Ramila E., Helms, Louisa, Cruz, Nelly M., Vincent, Thomas, Fu, Hongxia, Himmelfarb, Jonathan, Freedman, Benjamin S.

“…In polycystic kidney disease (PKD), fluid-filled cysts arise from tubules in kidneys and other organs. Human kidney organoids can reconstitute PKD cystogenesis…”
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Impaired Glucose and Insulin Homeostasis in Moderate-Severe CKD by de Boer, Ian H, Zelnick, Leila, Afkarian, Maryam, Ayers, Ernest, Curtin, Laura, Himmelfarb, Jonathan, Ikizler, T Alp, Kahn, Steven E, Kestenbaum, Bryan, Utzschneider, Kristina

“…Kidney disease leads to clinically relevant disturbances in glucose and insulin homeostasis, but the pathophysiology in moderate-severe CKD remains…”
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Simultaneous determination of total homocysteine, cysteine, cysteinylglycine, and glutathione in human plasma by high-performance liquid chromatography: Application to studies of oxidative stress by Nolin, Thomas D., McMenamin, M. Elizabeth, Himmelfarb, Jonathan

“…A sensitive, reproducible, and robust high-performance liquid chromatography (HPLC) method has been validated for simultaneously determining total…”
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Comparison of the Complexity of Patients Seen by Different Medical Subspecialists in a Universal Health Care System by Tonelli, Marcello, Wiebe, Natasha, Manns, Braden J, Klarenbach, Scott W, James, Matthew T, Ravani, Pietro, Pannu, Neesh, Himmelfarb, Jonathan, Hemmelgarn, Brenda R

“…Clinical experience suggests that there are substantial differences in patient complexity across medical specialties, but empirical data are lacking. To…”
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