Search Results - "Himmel, Daniel M"

Non-Nucleoside Reverse Transcriptase Inhibitors Join Forces with Integrase Inhibitors to Combat HIV by Himmel, Daniel M., Arnold, Eddy

“…In the treatment of acquired immune deficiency syndrome (AIDS), the diarylpyrimidine (DAPY) analogs etravirine (ETR) and rilpivirine (RPV) have been widely…”
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Structure and Function of HIV-1 Reverse Transcriptase: Molecular Mechanisms of Polymerization and Inhibition by Sarafianos, Stefan G., Marchand, Bruno, Das, Kalyan, Himmel, Daniel M., Parniak, Michael A., Hughes, Stephen H., Arnold, Eddy

“…The rapid replication of HIV-1 and the errors made during viral replication cause the virus to evolve rapidly in patients, making the problems of vaccine…”
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Identification of Alternative Binding Sites for Inhibitors of HIV-1 Ribonuclease H Through Comparative Analysis of Virtual Enrichment Studies by Felts, Anthony K, LaBarge, Krystal, Bauman, Joseph D, Patel, Dishaben V, Himmel, Daniel M, Arnold, Eddy, Parniak, Michael A, Levy, Ronald M

“…The ribonuclease H (RNase H) domain on the p66 monomer of HIV-1 reverse transcriptase enzyme has become a target for inhibition. The active site is one…”
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The On–Off Switch in Regulated Myosins: Different Triggers but Related Mechanisms by Himmel, Daniel M., Mui, Suet, O’Neall-Hennessey, Elizabeth, Szent-Györgyi, Andrew G., Cohen, Carolyn

“…In regulated myosin, motor and enzymatic activities are toggled between the on-state and off-state by a switch located on its lever arm domain, here called the…”
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Myosin Subfragment 1 Structures Reveal a Partially Bound Nucleotide and a Complex Salt Bridge That Helps Couple Nucleotide and Actin Binding by Risal, Dipesh, Gourinath, S., Himmel, Daniel M., Szent-Györgyi, Andrew G., Cohen, Carolyn

“…Structural studies of myosin have induced some of the conformational changes that occur in this protein during the contractile cycle, and we have now observed…”
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Exploring structural variability in X-ray crystallographic models using protein local optimization by torsion-angle sampling by Knight, Jennifer L., Zhou, Zhiyong, Gallicchio, Emilio, Himmel, Daniel M., Friesner, Richard A., Arnold, Eddy, Levy, Ronald M.

“…Modeling structural variability is critical for understanding protein function and for modeling reliable targets for in silico docking experiments. Because of…”
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Structure of HIV-1 Reverse Transcriptase with the Inhibitor β-Thujaplicinol Bound at the RNase H Active Site by Himmel, Daniel M., Maegley, Karen A., Pauly, Tom A., Bauman, Joseph D., Das, Kalyan, Dharia, Chhaya, Clark, Arthur D., Ryan, Kevin, Hickey, Michael J., Love, Robert A., Hughes, Stephen H., Bergqvist, Simon, Arnold, Eddy

“…Novel inhibitors are needed to counteract the rapid emergence of drug-resistant HIV variants. HIV-1 reverse transcriptase (RT) has both DNA polymerase and…”
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Structure of a Dihydroxycoumarin Active-Site Inhibitor in Complex with the RNase H Domain of HIV-1 Reverse Transcriptase and Structure–Activity Analysis of Inhibitor Analogs by Himmel, Daniel M., Myshakina, Nataliya S., Ilina, Tatiana, Van Ry, Alexander, Ho, William C., Parniak, Michael A., Arnold, Eddy

“…Human immunodeficiency virus (HIV) encodes four essential enzymes: protease, integrase, reverse transcriptase (RT)-associated DNA polymerase, and RT-associated…”
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Synthesis, Activity, and Structural Analysis of Novel α-Hydroxytropolone Inhibitors of Human Immunodeficiency Virus Reverse Transcriptase-Associated Ribonuclease H by Chung, Suhman, Himmel, Daniel M, Jiang, Jian-Kang, Wojtak, Krzysztof, Bauman, Joseph D, Rausch, Jason W, Wilson, Jennifer A, Beutler, John A, Thomas, Craig J, Arnold, Eddy, Le Grice, Stuart F.J

“…The α-hydroxytroplone, manicol (5,7-dihydroxy-2-isopropenyl-9-methyl-1,2,3,4-tetrahydro-benzocyclohepten-6-one), potently and specifically inhibits…”
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Rigor-like Structures from Muscle Myosins Reveal Key Mechanical Elements in the Transduction Pathways of This Allosteric Motor by Yang, Yuting, Gourinath, S., Kovács, Mihály, Nyitray, László, Reutzel, Robbie, Himmel, Daniel M., O'Neall-Hennessey, Elizabeth, Reshetnikova, Ludmilla, Szent-Györgyi, Andrew G., Brown, Jerry H., Cohen, Carolyn

“…Unlike processive cellular motors such as myosin V, whose structure has recently been determined in a “rigor-like” conformation, myosin II from contracting…”
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HIV-1 Reverse Transcriptase Structure with RNase H Inhibitor Dihydroxy Benzoyl Naphthyl Hydrazone Bound at a Novel Site by Himmel, Daniel M, Sarafianos, Stefan G, Dharmasena, Sanjeewa, Hossain, Mohammed M, McCoy-Simandle, Kessler, Ilina, Tatiana, Clark, Arthur D, Knight, Jennifer L, Julias, John G, Clark, Patrick K, Krogh-Jespersen, Karsten, Levy, Ronald M, Hughes, Stephen H, Parniak, Michael A, Arnold, Eddy

“…The rapid emergence of drug-resistant variants of human immunodeficiency virus, type 1 (HIV-1), has limited the efficacy of anti-acquired immune deficiency…”
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Crystal Structures for HIV-1 Reverse Transcriptase in Complexes with Three Pyridinone Derivatives:  A New Class of Non-Nucleoside Inhibitors Effective against a Broad Range of Drug-Resistant Strains by Himmel, Daniel M, Das, Kalyan, Clark, Arthur D, Hughes, Stephen H, Benjahad, Abdellah, Oumouch, Said, Guillemont, Jérôme, Coupa, Sophie, Poncelet, Alain, Csoka, Imre, Meyer, Christophe, Andries, Koen, Nguyen, Chi Hung, Grierson, David S, Arnold, Eddy

“…In the treatment of AIDS, the efficacy of all drugs, including non-nucleoside inhibitors (NNRTIs) of HIV-1 reverse transcriptase (RT), has been limited by the…”
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Crystal Structure of Scallop Myosin S1 in the Pre-Power Stroke State to 2.6 Å Resolution: Flexibility and Function in the Head by Gourinath, S., Himmel, Daniel M., Brown, Jerry H., Reshetnikova, Ludmilla, Szent-Györgyi, Andrew G., Cohen, Carolyn

“…We have extended the X-ray structure determination of the complete scallop myosin head in the pre-power stroke state to 2.6 Å resolution, allowing an atomic…”
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Crystal engineering of HIV-1 reverse transcriptase for structure-based drug design by Bauman, Joseph D, Das, Kalyan, Ho, William C, Baweja, Mukta, Himmel, Daniel M, Clark, Arthur D. Jr, Oren, Deena A, Boyer, Paul L, Hughes, Stephen H, Shatkin, Aaron J, Arnold, Eddy

“…HIV-1 reverse transcriptase (RT) is a primary target for anti-AIDS drugs. Structures of HIV-1 RT, usually determined at ~2.5-3.0 Å resolution, are important…”
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4-Benzyl and 4-Benzoyl-3-dimethylaminopyridin-2(1H)-ones:  In Vitro Evaluation of New C-3-Amino-Substituted and C-5,6-Alkyl-Substituted Analogues against Clinically Important HIV Mutant Strains by Benjahad, Abdellah, Croisy, Martine, Monneret, Claude, Bisagni, Emile, Mabire, Dominique, Coupa, Sophie, Poncelet, Alain, Csoka, Imre, Guillemont, Jérôme, Meyer, Christophe, Andries, Koen, Pauwels, Rudi, de Béthune, Marie-Pierre, Himmel, Daniel M, Das, Kalyan, Arnold, Eddy, Nguyen, Chi Hung, Grierson, David S

“…In a program to optimize the anti-HIV activity of the 4-benzyl and 4-benzoyl-3-dimethylaminopyridinones 9 and 10, lead compounds in a new class of highly…”
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Introducing Our Authors by Hang, Howard C, Warthaka, Mangalika, Worthington, Andrew, Sayut, Daniel J, Himmel, Daniel M, Sarafianos, Stefan G

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Crystal Structure of Scallop Myosin S1 in the Pre-Power Stroke State to 2.6 Å Resolution by Gourinath, S., Himmel, Daniel M., Brown, Jerry H., Reshetnikova, Ludmilla, Szent-Györgyi, Andrew G., Cohen, Carolyn

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Structure of HIV-1 Reverse Transcriptase with the Inhibitor b-Thujaplicinol Bound at the RNase H Active Site by Himmel, Daniel M, Maegley, Karen A, Pauly, Tom A, Bauman, Joseph D, Das, Kalyan, Dharia, Chhaya, Clark, Arthur D, Ryan, Kevin, Hickey, Michael J, Love, Robert A, Hughes, Stephen H, Bergqvist, Simon, Arnold, Eddy

“…Novel inhibitors are needed to counteract the rapid emergence of drug-resistant HIV variants. HIV-1 reverse transcriptase (RT) has both DNA polymerase and…”
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