Search Results - "Himes, Paul M"
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Exploring the Post-translational Enzymology of PaaA by mRNA Display
Published in Journal of the American Chemical Society (18-03-2020)“…PaaA is a RiPP enzyme that catalyzes the transformation of two glutamic acid residues within a substrate peptide into the bicyclic core of Pantocin A. Here,…”
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Production of Sactipeptides in Escherichia coli: Probing the Substrate Promiscuity of Subtilosin A Biosynthesis
Published in ACS chemical biology (17-06-2016)“…Sactipeptides are peptide-derived natural products that are processed by remarkable, radical-mediated cysteine sulfur to α-carbon coupling reactions. The…”
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Structural Insights into Thioether Bond Formation in the Biosynthesis of Sactipeptides
Published in Journal of the American Chemical Society (30-08-2017)“…Sactipeptides are ribosomally synthesized peptides that contain a characteristic thioether bridge (sactionine bond) that is installed posttranslationally and…”
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Structural Insights into Thioether Bond Formation in the Biosynthesis of Sactipeptides
Published in Journal of the American Chemical Society (18-08-2017)Get full text
Journal Article