Search Results - "Himes, Benjamin"

emClarity: software for high-resolution cryo-electron tomography and subtomogram averaging by Himes, Benjamin A., Zhang, Peijun

“…Macromolecular complexes are intrinsically flexible and often challenging to purify for structure determination by single-particle cryo-electron microscopy…”
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Complementary and Alternative Medicine for Gliomas: Systematic Review and Critical Appraisal of Current Literature by Kerezoudis, Panagiotis, Kerezoudi, Evangelia N, Choudhry, Abdurehman, Himes, Benjamin T, Parney, Ian F

“…Many patients with glioma and their caregivers seek complementary and alternative medicine (CAM) methods to comfort themselves, cope with cancer medication…”
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High-resolution in situ structure determination by cryo-electron tomography and subtomogram averaging using emClarity by Ni, Tao, Frosio, Thomas, Mendonça, Luiza, Sheng, Yuewen, Clare, Daniel, Himes, Benjamin A., Zhang, Peijun

“…Cryo-electron tomography and subtomogram averaging (STA) has developed rapidly in recent years. It provides structures of macromolecular complexes in situ and…”
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Treatment Strategies in Diffuse Midline Gliomas With the H3K27M Mutation: The Role of Convection-Enhanced Delivery in Overcoming Anatomic Challenges by Himes, Benjamin T, Zhang, Liang, Daniels, David J

“…Diffuse midline gliomas harboring the H3 K27M mutation-including the previously named diffuse intrinsic pontine glioma (DIPG)-are lethal high-grade pediatric…”
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Locating macromolecular assemblies in cells by 2D template matching with cisTEM by Lucas, Bronwyn A, Himes, Benjamin A, Xue, Liang, Grant, Timothy, Mahamid, Julia, Grigorieff, Nikolaus

“…For a more complete understanding of molecular mechanisms, it is important to study macromolecules and their assemblies in the broader context of the cell…”
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Immunosuppression in Glioblastoma: Current Understanding and Therapeutic Implications by Himes, Benjamin T., Geiger, Philipp A., Ayasoufi, Katayoun, Bhargav, Adip G., Brown, Desmond A., Parney, Ian F.

“…Glioblastoma (GBM) is the most common primary brain tumor in adults an carries and carries a terrible prognosis. The current regiment of surgical resection,…”
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Cryo-TEM simulations of amorphous radiation-sensitive samples using multislice wave propagation by Himes, Benjamin, Grigorieff, Nikolaus

“…Image simulation plays a central role in the development and practice of high-resolution electron microscopy, including transmission electron microscopy of…”
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Baited reconstruction with 2D template matching for high-resolution structure determination in vitro and in vivo without template bias by Lucas, Bronwyn A, Himes, Benjamin A, Grigorieff, Nikolaus

“…Previously we showed that 2D template matching (2DTM) can be used to localize macromolecular complexes in images recorded by cryogenic electron microscopy…”
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Cyclophilin A stabilizes the HIV-1 capsid through a novel non-canonical binding site by Liu, Chuang, Perilla, Juan R., Ning, Jiying, Lu, Manman, Hou, Guangjin, Ramalho, Ruben, Himes, Benjamin A., Zhao, Gongpu, Bedwell, Gregory J., Byeon, In-Ja, Ahn, Jinwoo, Gronenborn, Angela M., Prevelige, Peter E., Rousso, Itay, Aiken, Christopher, Polenova, Tatyana, Schulten, Klaus, Zhang, Peijun

“…The host cell factor cyclophilin A (CypA) interacts directly with the HIV-1 capsid and regulates viral infectivity. Although the crystal structure of CypA in…”
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Recurrent papillary craniopharyngioma with BRAF V600E mutation treated with dabrafenib: case report by Himes, Benjamin T, Ruff, Michael W, Van Gompel, Jaimie J, Park, Sean S, Galanis, Evanthia, Kaufmann, Timothy J, Uhm, Joon H

“…The authors present the case of a man with a papillary craniopharyngioma, first diagnosed at 47 years of age, who experienced multiple recurrences. Review of…”
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Deploying Kinase Inhibitors to Study Pediatric Gliomas by Himes, Benjamin T, Zhang, Liang, Daniels, David J

“…Pediatric midline gliomas are a uniformly fatal disease for which there is no cure. The location of these tumors makes surgical resection impossible, and so…”
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Immune checkpoint pathways in glioblastoma: a diverse and evolving landscape by Inocencio, Julio F, Mitrasinovic, Stefan, Asad, Mohammad, Parney, Ian F, Zang, Xingxing, Himes, Benjamin T

“…Immune checkpoint (IC) inhibition in glioblastoma (GBM) has not shown promising results in the last decade compared to other solid tumors. Several factors…”
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The role of extracellular vesicles and PD-L1 in glioblastoma-mediated immunosuppressive monocyte induction by Himes, Benjamin T, Peterson, Timothy E, de Mooij, Tristan, Garcia, Luz M Cumba, Jung, Mi-Yeon, Uhm, Sarah, Yan, David, Tyson, Jasmine, Jin-Lee, Helen J, Parney, Daniel, Abukhadra, Yasmina, Gustafson, Michael P, Dietz, Allan B, Johnson, Aaron J, Dong, Haidong, Maus, Rachel L, Markovic, Svetomir, Lucien, Fabrice, Parney, Ian F

“…Abstract Background Immunosuppression in glioblastoma (GBM) is an obstacle to effective immunotherapy. GBM-derived immunosuppressive monocytes are central to…”
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In vitro protease cleavage and computer simulations reveal the HIV-1 capsid maturation pathway by Ning, Jiying, Erdemci-Tandogan, Gonca, Yufenyuy, Ernest L., Wagner, Jef, Himes, Benjamin A., Zhao, Gongpu, Aiken, Christopher, Zandi, Roya, Zhang, Peijun

“…HIV-1 virions assemble as immature particles containing Gag polyproteins that are processed by the viral protease into individual components, resulting in the…”
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CryoEM-based hybrid modeling approaches for structure determination by Cassidy, C Keith, Himes, Benjamin A, Luthey-Schulten, Zaida, Zhang, Peijun

“…•CryoEM provides near-native structural data for diverse biomolecular complexes.•Hybrid modeling enables construction/refinement of atomic models using cryoEM…”
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ZNF117 regulates glioblastoma stem cell differentiation towards oligodendroglial lineage by Liu, Jun, Wang, Xiaoying, Chen, Ann T., Gao, Xingchun, Himes, Benjamin T., Zhang, Hongyi, Chen, Zeming, Wang, Jianhui, Sheu, Wendy C., Deng, Gang, Xiao, Yang, Zou, Pan, Zhang, Shenqi, Liu, Fuyao, Zhu, Yong, Fan, Rong, Patel, Toral R., Saltzman, W. Mark, Zhou, Jiangbing

“…Glioblastoma (GBM) is a deadly disease without effective treatment. Because glioblastoma stem cells (GSCs) contribute to tumor resistance and recurrence,…”
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Controlled Bacterial Lysis for Electron Tomography of Native Cell Membranes by Fu, Xiaofeng, Himes, Benjamin A., Ke, Danxia, Rice, William J., Ning, Jiying, Zhang, Peijun

“…Cryo-electron tomography (cryoET) has become a powerful tool for direct visualization of 3D structures of native biological specimens at molecular resolution,…”
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Brain cancer induces systemic immunosuppression through release of non-steroid soluble mediators by Ayasoufi, Katayoun, Pfaller, Christian K, Evgin, Laura, Khadka, Roman H, Tritz, Zachariah P, Goddery, Emma N, Fain, Cori E, Yokanovich, Lila T, Himes, Benjamin T, Jin, Fang, Zheng, Jiaying, Schuelke, Matthew R, Hansen, Michael J, Tung, Wesley, Parney, Ian F, Pease, Larry R, Vile, Richard G, Johnson, Aaron J

“…Immunosuppression of unknown aetiology is a hallmark feature of glioblastoma and is characterized by decreased CD4 T-cell counts and downregulation of major…”
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CryoEM and computer simulations reveal a novel kinase conformational switch in bacterial chemotaxis signaling by Cassidy, C Keith, Himes, Benjamin A, Alvarez, Frances J, Ma, Jun, Zhao, Gongpu, Perilla, Juan R, Schulten, Klaus, Zhang, Peijun

“…Chemotactic responses in bacteria require large, highly ordered arrays of sensory proteins to mediate the signal transduction that ultimately controls cell…”
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Contemporary analysis of the intraoperative and perioperative complications of neurosurgical procedures performed in the sitting position by Himes, Benjamin T, Mallory, Grant W, Abcejo, Arnoley S, Pasternak, Jeffrey, Atkinson, John L D, Meyer, Fredric B, Marsh, W Richard, Link, Michael J, Clarke, Michelle J, Perkins, William, Van Gompel, Jamie J

“…OBJECTIVE Historically, performing neurosurgery with the patient in the sitting position offered advantages such as improved visualization and gravity-assisted…”
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