Search Results - "Hilton, Stephen T"

Intramolecular Acylal Cyclisation (IAC) as an Efficient Synthetic Strategy towards the Total Synthesis of Erythrina Alkaloid Derivatives by Monaco, Alessandra, Aliev, Abil E., Hilton, Stephen T.

“…Compounds that comprise the erythrina alkaloid class of natural products are based on a tetracyclic spiroamine framework and exhibit a range of biological…”
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Patient-specific 3D scanned and 3D printed antimicrobial polycaprolactone wound dressings by Muwaffak, Zaid, Goyanes, Alvaro, Clark, Vivienne, Basit, Abdul W., Hilton, Stephen T., Gaisford, Simon

“…[Display omitted] The increasing prevalence of wound infections caused by antibiotic resistant bacteria is an urgent challenge facing modern medicine. To…”
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The effect of sodium hypochlorite concentration and irrigation needle extension on biofilm removal from a simulated root canal model by Mohmmed, Saifalarab A., Vianna, Morgana E., Penny, Matthew R., Hilton, Stephen T., Knowles, Jonathan C.

“…To investigate the effect of sodium hypochlorite concentration and needle extension on removal of Enterococcus faecalis biofilm, sixty root canal models were…”
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The influence of positional isomerism on G-quadruplex binding and anti-proliferative activity of tetra-substituted naphthalene diimide compounds by Mpima, Sheila, Ohnmacht, Stephan A., Barletta, Maria, Husby, Jarmila, Pett, Luke C., Gunaratnam, Mekala, Hilton, Stephen T., Neidle, Stephen

“…The synthesis together with biophysical and biological evaluation of a series of tetra-substituted naphthalene diimide (ND) compounds, are presented. These…”
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A Preliminary Investigation of Additive Manufacture to Fabricate Human Nail Plate Surrogates for Pharmaceutical Testing by Sil, Bruno C, Patel, Avnish, Crowther, Jonathan M, Moore, David J, Hadgraft, Jonathan, Hilton, Stephen T, Lane, Majella E

“…In vitro permeation studies using nail clippings or nail plates are commonly used in the development of transungual formulations. However, there are ethical,…”
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Rapid Lewis Acid Screening and Reaction Optimization Using 3D-Printed Catalyst-Impregnated Stirrer Devices in the Synthesis of Heterocycles by Thavarajah, Rumintha, Penny, Matthew R., Torii, Ryo, Hilton, Stephen T.

“…We describe the development of Lewis acid (LA) catalyst-impregnated 3D-printed stirrer devices and demonstrate their ability to facilitate the rapid screening…”
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Synthesis of CHF2‑Containing Heterocycles through Oxy-difluoromethylation Using Low-Cost 3D Printed PhotoFlow Reactors by Zhang, Jinlei, Selmi-Higashi, Elias, Zhang, Shen, Jean, Alexandre, Hilton, Stephen T., Cambeiro, Xacobe C., Arseniyadis, Stellios

“…We report here a highly straightforward access to a variety of CHF2-containing heterocycles, including lactones, tetrahydrofurans, tetrahydropyrans,…”
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Synthesis of CHF 2 -Containing Heterocycles through Oxy-difluoromethylation Using Low-Cost 3D Printed PhotoFlow Reactors by Zhang, Jinlei, Selmi-Higashi, Elias, Zhang, Shen, Jean, Alexandre, Hilton, Stephen T, Cambeiro, Xacobe C, Arseniyadis, Stellios

“…We report here a highly straightforward access to a variety of CHF -containing heterocycles, including lactones, tetrahydrofurans, tetrahydropyrans,…”
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Development and analysis of a novel loading technique for FDM 3D printed systems: Microwave-assisted impregnation of gastro-retentive PVA capsular devices by Saviano, Marilena, Bowles, Benjamin J., Penny, Matthew R., Ishaq, Ahtsham, Muwaffak, Zaid, Falcone, Giovanni, Russo, Paola, Hilton, Stephen T.

“…[Display omitted] In this paper, we describe a modular post-printing loading protocol for a 3D printed gastro-retentive drug delivery system. Fused Deposition…”
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3D printed reactors and Kessil lamp holders for flow photochemistry: design and system standardization by Penny, Matthew R., Hilton, Stephen T.

“…A low-cost 3D printed standardized flow-photochemistry setup has been designed and developed for use with a pressure-driven flow system using photochemistry…”
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Modular 3D Printed Compressed Air Driven Continuous‐Flow Systems for Chemical Synthesis by Penny, Matthew R., Rao, Zenobia X., Peniche, Bruno Felício, Hilton, Stephen T.

“…In this present study, we describe the development of a low‐cost, small‐footprint and modular 3D printed continuous‐flow system that readily attaches to…”
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3D‐Printed Polypropylene Continuous‐Flow Column Reactors: Exploration of Reactor Utility in SNAr Reactions and the Synthesis of Bicyclic and Tetracyclic Heterocycles by Rao, Zenobia X., Patel, Bhaven, Monaco, Alessandra, Cao, Zi Jing, Barniol‐Xicota, Marta, Pichon, Enora, Ladlow, Mark, Hilton, Stephen T.

“…3D printing has the potential to transform the way in which chemical reactions are carried out due to its low‐cost, ease‐of‐use as a technology and its…”
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Rapid, simple and inexpensive production of custom 3D printed equipment for large-volume fluorescence microscopy by Tyson, Adam L., Hilton, Stephen T., Andreae, Laura C.

“…[Display omitted] The cost of 3D printing has reduced dramatically over the last few years and is now within reach of many scientific laboratories. This work…”
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Digitisation of a modular plug and play 3D printed continuous flow system for chemical synthesis by Montaner, Mireia Benito, Penny, Matthew R, Hilton, Stephen T

“…We describe the development of a digital modular 3D printed continuous flow system to carry out both classical and photochemical synthesis that uses a novel PC…”
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Design, 3D printing and validation of a novel low‐cost high‐capacity sitting‐drop bridge for protein crystallization by Talapatra, Sandeep K., Penny, Matthew R., Hilton, Stephen T., Kozielski, Frank

“…Sitting‐drop protein crystallization is not used as commonly as the hanging‐drop method for crystal optimization owing to the limitations of commercially…”
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Clinical impact of customised positive airway pressure (PAP) therapy interfaces versus usual care in the treatment of patients with sleep-disordered breathing (3DPiPPIn): a randomised controlled trial protocol by Mansell, Stephanie K, Mandal, Swapna, Ridout, Deborah, Olsen, Oliver, Gowing, Francesca, Kilbride, Cherry, Hilton, Stephen T, Main, Eleanor, Schievano, Silvia

“…Introduction Sleep-disordered breathing affects 1.6 million people in the UK. The recognised treatment is positive airway pressure (PAP) therapy, delivered via…”
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Epidithiodiketopiperazines Inhibit Protein Degradation by Targeting Proteasome Deubiquitinase Rpn11 by Li, Jing, Zhang, Yaru, Da Silva Sil Dos Santos, Bruno, Wang, Feng, Ma, Yuyong, Perez, Christian, Yang, Yanling, Peng, Junmin, Cohen, Seth M, Chou, Tsui-Fen, Hilton, Stephen T, Deshaies, Raymond J

“…The 26S proteasome is the major proteolytic machine for breaking down cytosolic and nuclear proteins in eukaryotes. Due to the lack of a suitable assay, it is…”
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Breaking the Access to Education Barrier: Enhancing HPLC Learning with Virtual Reality by Taylor, Mae, Abdullah, Nazrul Bin, Al-Dargazelli, Ayah, Montaner, Mireia Benito, Kareem, Fatma, Locks, Amy, Cao, Zijing, Bowles, Benjamin, Sarraf, Jean Charles, Fajinmi, Tamara, Muwaffak, Zaid, Beckwith, Cory, Parkinson, Gary N., Waller, Zoë A. E., Szulc, Blanka R., Hilton, Stephen T.

“…This research focuses on an innovative approach to the practical teaching of High Performance Liquid Chromatography (HPLC), specifically exploring the…”
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Short Total Synthesis of (±)-[gamma]-Lycorane by a Sequential Intramolecular Acylal Cyclisation (IAC) and Intramolecular Heck Addition Reaction by Monaco, Alessandra, Szulc, Blanka R, Rao, Zenobia X, Barniol-Xicota, Marta, Sehailia, Moussa, Borges, Bruno M A, Hilton, Stephen T

“…An intramolecular acylal cyclisation (IAC) approach to the synthesis of a range of bicyclic heterocycles is reported. As an example of the utility of the IAC…”
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Physiological signature of a novel potentiator of AMPA receptor signalling by Szulc, Blanka R, Hilton, Stephen T, Ruiz, Arnaud J

“…We have synthesized a novel small molecule based on the pyrrolidinone-containing core structure of clausenamide, which is a candidate anti-dementia drug. The…”
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