Search Results - "Hilton, Mary Beth"

GPR124 Functions as a WNT7-Specific Coactivator of Canonical β-Catenin Signaling by Posokhova, Ekaterina, Shukla, Animesh, Seaman, Steven, Volate, Suresh, Hilton, Mary Beth, Wu, Bofan, Morris, Holly, Swing, Deborah A., Zhou, Ming, Zudaire, Enrique, Rubin, Jeffrey S., St. Croix, Brad

“…G protein-coupled receptor 124 (GPR124) is an orphan receptor in the adhesion family of GPCRs, and previous global or endothelial-specific disruption of Gpr124…”
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TEM8/ANTXR1 Blockade Inhibits Pathological Angiogenesis and Potentiates Tumoricidal Responses against Multiple Cancer Types by Chaudhary, Amit, Hilton, Mary Beth, Seaman, Steven, Haines, Diana C., Stevenson, Susan, Lemotte, Peter K., Tschantz, William R., Zhang, Xiaoyan M., Saha, Saurabh, Fleming, Tony, St. Croix, Brad

“…Current antiangiogenic agents used to treat cancer only partially inhibit neovascularization and cause normal tissue toxicities, fueling the need to identify…”
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Essential Regulation of Lung Surfactant Homeostasis by the Orphan G Protein-Coupled Receptor GPR116 by Yang, Mi Young, Hilton, Mary Beth, Seaman, Steven, Haines, Diana C., Nagashima, Kunio, Burks, Christina M., Tessarollo, Lino, Ivanova, Pavlina T., Brown, H. Alex, Umstead, Todd M., Floros, Joanna, Chroneos, Zissis C., St. Croix, Brad

“…GPR116 is an orphan seven-pass transmembrane receptor whose function has been unclear. Global disruption of the Gpr116 gene in mice revealed an unexpected,…”
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Eradication of Tumors through Simultaneous Ablation of CD276/B7-H3-Positive Tumor Cells and Tumor Vasculature by Seaman, Steven, Zhu, Zhongyu, Saha, Saurabh, Zhang, Xiaoyan M., Yang, Mi Young, Hilton, Mary Beth, Morris, Karen, Szot, Christopher, Morris, Holly, Swing, Deborah A., Tessarollo, Lino, Smith, Sean W., Degrado, Sylvia, Borkin, Dmitry, Jain, Nareshkumar, Scheiermann, Julia, Feng, Yang, Wang, Yanping, Li, Jinyu, Welsch, Dean, DeCrescenzo, Gary, Chaudhary, Amit, Zudaire, Enrique, Klarmann, Kimberly D., Keller, Jonathan R., Dimitrov, Dimiter S., St. Croix, Brad

“…Targeting the tumor vasculature with antibody-drug conjugates (ADCs) is a promising anti-cancer strategy that in order to be realized must overcome several…”
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Tumor stroma-targeted antibody-drug conjugate triggers localized anticancer drug release by Szot, Christopher, Saha, Saurabh, Zhang, Xiaoyan M, Zhu, Zhongyu, Hilton, Mary Beth, Morris, Karen, Seaman, Steven, Dunleavey, James M, Hsu, Kuo-Sheng, Yu, Guo-Jun, Morris, Holly, Swing, Deborah A, Haines, Diana C, Wang, Yanping, Hwang, Jennifer, Feng, Yang, Welsch, Dean, DeCrescenzo, Gary, Chaudhary, Amit, Zudaire, Enrique, Dimitrov, Dimiter S, St Croix, Brad

“…Although nonmalignant stromal cells facilitate tumor growth and can occupy up to 90% of a solid tumor mass, better strategies to exploit these cells for…”
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Cancer cell survival depends on collagen uptake into tumor-associated stroma by Hsu, Kuo-Sheng, Dunleavey, James M., Szot, Christopher, Yang, Liping, Hilton, Mary Beth, Morris, Karen, Seaman, Steven, Feng, Yang, Lutz, Emily M., Koogle, Robert, Tomassoni-Ardori, Francesco, Saha, Saurabh, Zhang, Xiaoyan M., Zudaire, Enrique, Bajgain, Pradip, Rose, Joshua, Zhu, Zhongyu, Dimitrov, Dimiter S., Cuttitta, Frank, Emenaker, Nancy J., Tessarollo, Lino, St. Croix, Brad

“…Collagen I, the most abundant protein in humans, is ubiquitous in solid tumors where it provides a rich source of exploitable metabolic fuel for cancer cells…”
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GPR124, an orphan G protein-coupled receptor, is required for CNS-specific vascularization and establishment of the blood-brain barrier by Cullen, Mike, Elzarrad, Mohammed K, Seaman, Steven, Zudaire, Enrique, Stevens, Janine, Yang, Mi Young, Li, Xiujie, Chaudhary, Amit, Xu, Lihong, Hilton, Mary Beth, Logsdon, Daniel, Hsiao, Emily, Stein, Erica V, Cuttitta, Frank, Haines, Diana C, Nagashima, Kunio, Tessarollo, Lino, St. Croix, Brad

“…Every organ in the body requires blood vessels for efficient delivery of oxygen and nutrients, but independent vascular beds are highly specialized to meet the…”
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Engineering CD276/B7-H3-targeted antibody-drug conjugates with enhanced cancer-eradicating capability by Feng, Yang, Lee, Jaewon, Yang, Liping, Hilton, Mary Beth, Morris, Karen, Seaman, Steven, Edupuganti, Veera V. Shivaji R., Hsu, Kuo-Sheng, Dower, Christopher, Yu, Guojun, So, Daeho, Bajgain, Pradip, Zhu, Zhongyu, Dimitrov, Dimiter S., Patel, Nimit L., Robinson, Christina M., Difilippantonio, Simone, Dyba, Marzena, Corbel, Amanda, Basuli, Falguni, Swenson, Rolf E., Kalen, Joseph D., Suthe, Sreedhar Reddy, Hussain, Myer, Italia, James S., Souders, Colby A., Gao, Ling, Schnermann, Martin J., St. Croix, Brad

“…CD276/B7-H3 represents a promising target for cancer therapy based on widespread overexpression in both cancer cells and tumor-associated stroma. In previous…”
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Host-Derived Tumor Endothelial Marker 8 Promotes the Growth of Melanoma by CULLEN, Mike, SEAMAN, Steven, CHAUDHARY, Amit, MI YOUNG YANG, HILTON, Mary Beth, LOGSDON, Daniel, HAINES, Diana C, TESSAROLLO, Lino, CROIX, Brad St

“…Tumor endothelial marker 8 (TEM8) was initially identified as a gene overexpressed in the vasculature of human tumors and was subsequently identified as an…”
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Combined Loss of Cdk2 and Cdk4 Results in Embryonic Lethality and Rb Hypophosphorylation by Berthet, Cyril, Klarmann, Kimberly D., Hilton, Mary Beth, Suh, Hyung Chan, Keller, Jonathan R., Kiyokawa, Hiroaki, Kaldis, Philipp

“…Mouse knockouts of Cdk2 and Cdk4 have demonstrated that, individually, these genes are not essential for viability. To investigate whether there is functional…”
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Cdk2 and Cdk4 Activities Are Dispensable for Tumorigenesis Caused by the Loss of p53 by Padmakumar, V. C., Aleem, Eiman, Berthet, Cyril, Hilton, Mary Beth, Kaldis, Philipp

“…Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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Rb/Cdk2/Cdk4 triple mutant mice elicit an alternative mechanism for regulation of the G₁/S transition by Li, Weimin, Kotoshiba, Shuhei, Berthet, Cyril, Hilton, Mary Beth, Kaldis, Philipp

“…The G₁/S-phase transition is a well-toned switch in the mammalian cell cycle. Cdk2, Cdk4, and the rate-limiting tumor suppressor retinoblastoma protein (Rb)…”
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p21 Inhibits Cdk1 in the absence of Cdk2 to maintain the G1/S phase DNA damage checkpoint by Satyanarayana, Ande, Hilton, Mary Beth, Kaldis, Philipp

“…Cdk1 was proposed to compensate for the loss of Cdk2. Here we present evidence that this is possible due to premature translocation of Cdk1 from the cytoplasm…”
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COX-2 inhibition potentiates antiangiogenic cancer therapy and prevents metastasis in preclinical models by Xu, Lihong, Stevens, Janine, Hilton, Mary Beth, Seaman, Steven, Conrads, Thomas P, Veenstra, Timothy D, Logsdon, Daniel, Morris, Holly, Swing, Deborah A, Patel, Nimit L, Kalen, Joseph, Haines, Diana C, Zudaire, Enrique, St Croix, Brad

“…Antiangiogenic agents that block vascular endothelial growth factor (VEGF) signaling are important components of current cancer treatment modalities but are…”
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Rb/Cdk2/Cdk4 triple mutant mice elicit an alternative mechanism for regulation of the G 1 /S transition by Li, Weimin, Kotoshiba, Shuhei, Berthet, Cyril, Hilton, Mary Beth, Kaldis, Philipp

“…The G 1 /S-phase transition is a well-toned switch in the mammalian cell cycle. Cdk2, Cdk4, and the rate-limiting tumor suppressor retinoblastoma protein (Rb)…”
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Rb/Cdk2/Cdk4 triple mutant mice elicit an alternative mechanism for regulation of the G^sub 1^/S transition by Li, Weimin, Kotoshiba, Shuhei, Berthet, Cyril, Hilton, Mary Beth, Kaldis, Philipp

“…The G.../S-phase transition is a well-toned switch in the mammalian cell cycle. Cdk2, Cdk4, and the rate-limiting tumor suppressor retinoblastoma protein (Rb)…”
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Rb/Cdk2/Cdk4 triple mutant mice elicit an alternative mechanism for regulation of the G sub(1)/S transition by Li, Weimin, Kotoshiba, Shuhei, Berthet, Cyril, Hilton, Mary Beth, Kaldis, Philipp

“…The G sub(1)/S-phase transition is a well-toned switch in the mammalian cell cycle. Cdk2, Cdk4, and the rate-limiting tumor suppressor retinoblastoma protein…”
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Rb/Cdk2/Cdk4 triple mutant mice elicit an alternative mechanism for regulation of the G₁/S transition by Li, Weimin, Kotoshiba, Shuhei, Berthet, Cyril, Hilton, Mary Beth, Kaldis, Philipp

“…The G₁/S-phase transition is a well-toned switch in the mammalian cell cycle. Cdk2, Cdk4, and the rate-limiting tumor suppressor retinoblastoma protein (Rb)…”
Get full text

GPR124 Functions as a WNT7-Specific Co-Activator of Canonical β-Catenin Signaling by Posokhova, Ekaterina, Shukla, Animesh, Seaman, Steven, Volate, Suresh, Hilton, Mary Beth, Wu, Bofan, Morris, Holly, Swing, Deborah A., Zhou, Ming, Zudaire, Enrique, Rubin, Jeffrey S., St. Croix, Brad

“…G-protein coupled receptor 124 (GPR124) is an orphan receptor in the adhesion family of GPCRs and previous global or endothelial-specific disruption of Gpr124…”
Get full text