Search Results - "Hilton, Jacob K."

Evidence that the TRPV1 S1-S4 membrane domain contributes to thermosensing by Kim, Minjoo, Sisco, Nicholas J., Hilton, Jacob K., Montano, Camila M., Castro, Manuel A., Cherry, Brian R., Levitus, Marcia, Van Horn, Wade D.

“…Sensing and responding to temperature is crucial in biology. The TRPV1 ion channel is a well-studied heat-sensing receptor that is also activated by vanilloid…”
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Tonic inhibition of the chloride/proton antiporter ClC-7 by PI(3,5)P2 is crucial for lysosomal pH maintenance by Leray, Xavier, Hilton, Jacob K, Nwangwu, Kamsi, Becerril, Alissa, Mikusevic, Vedrana, Fitzgerald, Gabriel, Amin, Anowarul, Weston, Mary R, Mindell, Joseph A

“…The acidic luminal pH of lysosomes, maintained within a narrow range, is essential for proper degrative function of the organelle and is generated by the…”
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Structural and Evolutionary Insights Point to Allosteric Regulation of TRP Ion Channels by Hilton, Jacob K, Kim, Minjoo, Van Horn, Wade D

“…Conspectus The familiar pungent taste of spicy food, the refreshing taste of mint, and many other physiological phenomena are mediated by transient receptor…”
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The effects of disease-causing ClC-7 mutations on lysosomal pH by Mikusevic, Vedrana, Hilton, Jacob K., Jethva, Reena, Mindell, Joseph A.

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Mechanism of ClC-7 transporter inhibition by the lysosomal phospholipid PI(3,5)P2 by Hilton, Jacob K., Mindell, Joseph A.

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Molecular dynamics characterization of the mechanism of inhibition of ClC-7 activity by PI(3)P by Sefah, Eric, Hilton, Jacob K., Mindell, Joseph A., Grabe, Michael

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Structure and inhibition mechanism of the human citrate transporter NaCT by Sauer, David B., Song, Jinmei, Wang, Bing, Hilton, Jacob K., Karpowich, Nathan K., Mindell, Joseph A., Rice, William J., Wang, Da-Neng

“…Citrate is best known as an intermediate in the tricarboxylic acid cycle of the cell. In addition to this essential role in energy metabolism, the…”
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Phosphoinositide-interacting regulator of TRP (PIRT) has opposing effects on human and mouse TRPM8 ion channels by Hilton, Jacob K., Salehpour, Taraneh, Sisco, Nicholas J., Rath, Parthasarathi, Van Horn, Wade D.

“…Transient receptor potential melastatin 8 (TRPM8) is a cold-sensitive ion channel with diverse physiological roles. TRPM8 activity is modulated by many…”
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New pieces to an old puzzle: identifying the warfarin-binding site that prevents clotting by Hilton, Jacob K, Van Horn, Wade D

“…Warfarin has been the most widely prescribed anticoagulant for decades. It functions by inhibiting the membrane enzyme vitamin K epoxide reductase (VKOR), but…”
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Understanding Thermosensitive Transient Receptor Potential Channels as Versatile Polymodal Cellular Sensors by Hilton, Jacob K, Rath, Parthasarathi, Helsell, Cole V. M, Beckstein, Oliver, Van Horn, Wade D

“…Transient receptor potential (TRP) ion channels are eukaryotic polymodal sensors that function as molecular cellular signal integrators. TRP family members…”
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Implications of Human Transient Receptor Potential Melastatin 8 (TRPM8) Channel Gating from Menthol Binding Studies of the Sensing Domain by Rath, Parthasarathi, Hilton, Jacob K, Sisco, Nicholas J, Van Horn, Wade D

“…The transient receptor potential melastatin 8 (TRPM8) ion channel is the primary cold sensor in humans. TRPM8 is gated by physiologically relevant cold…”
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Structure-Based Design of Novel Biphenyl Amide Antagonists of Human Transient Receptor Potential Cation Channel Subfamily M Member 8 Channels with Potential Implications in the Treatment of Sensory Neuropathies by Journigan, V. Blair, Feng, Zhiwei, Rahman, Saifur, Wang, Yuanqiang, Amin, A. R. M. Ruhul, Heffner, Colleen E, Bachtel, Nicholas, Wang, Siyi, Gonzalez-Rodriguez, Sara, Fernández-Carvajal, Asia, Fernández-Ballester, Gregorio, Hilton, Jacob K, Van Horn, Wade D, Ferrer-Montiel, Antonio, Xie, Xiang-Qun, Rahman, Taufiq

“…Structure–activity relationship studies of a reported menthol-based transient receptor potential cation channel subfamily M member 8 channel (TRPM8)…”
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Biophysical Effects of Disease Mutants in the Lysosomal Cl-/H+ Exchanger CLC-7 by Hilton, Jacob K., Mindell, Joseph A.

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Tonic inhibition of the chloride/proton antiporter CLC-7 by pi(3,5)p2 is crucial for lysosomal pH maintenance by Hilton, Jacob K., Leray, Xavier, Nwangwu, Kamsiyochukwu, Becerril, Alissa J., Fitzgerald, Gabriel, Amin, Anowarul, Weston, Mary, Mindell, Joseph A.

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Mechanistic and Structural Studies of PIRT Regulation of TRPM8 by Van Horn, Wade D., Luu, Dustin D., Kim, Minjoo, Hilton, Jacob K., Montano, Camila

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Characterization of HTRPM8 Conformational Dynamic Utilizing Solution NMR by Mebrat, Mubark, Hilton, Jacob K., Morelan, Danielle, Van Horn, Wade D.

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Tonic inhibition of the chloride/proton antiporter ClC-7 by PIP2 is crucial for lysosomal pH maintenance by Leray, Xavier, Hilton, Jacob K, Nwangwu, Kamsi, Becerril, Alissa, Mikusevic, Vedrana, Fitzgerald, Gabriel, Amin, Anowarul, Weston, Mary R, Mindell, Joseph A

“…The acidic luminal pH of lysosomes, maintained within a narrow range, is essential for proper degrative function of the organelle and is generated by the…”
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Competitive Interactions of PIRT and PI(4,5)P2 Modulate TRPM8 by Sisco, Nicholas, Rath, Parthasarathi, Hilton, Jacob K., Helsell, Cole V.M., Van Horn, Wade D.

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Biophysical Characterization of Human Transient Receptor Potential Melastatin 8 (TRPM8) Ion Channel Modulation by Phosphoinositide Regulator of TRP (PIRT) by Hilton, Jacob K., Sisco, Nicholas J., Rath, Parthasarathi, VanHorn, Wade D.

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Implications of human TRPM8 channel gating from menthol binding studies of the sensing domain by Rath, Parthasarathi, Hilton, Jacob K., Sisco, Nicholas J., Van Horn, Wade D.

“…The transient receptor potential melastatin 8 (TRPM8) ion channel is the primary cold sensor in humans. TRPM8 is gated by physiologically relevant cold…”
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