Search Results - "Hilton, Douglas"

The Pseudokinase MLKL Mediates Necroptosis via a Molecular Switch Mechanism by Murphy, James M., Czabotar, Peter E., Hildebrand, Joanne M., Lucet, Isabelle S., Zhang, Jian-Guo, Alvarez-Diaz, Silvia, Lewis, Rowena, Lalaoui, Najoua, Metcalf, Donald, Webb, Andrew I., Young, Samuel N., Varghese, Leila N., Tannahill, Gillian M., Hatchell, Esme C., Majewski, Ian J., Okamoto, Toru, Dobson, Renwick C.J., Hilton, Douglas J., Babon, Jeffrey J., Nicola, Nicos A., Strasser, Andreas, Silke, John, Alexander, Warren S.

“…Mixed lineage kinase domain-like (MLKL) is a component of the “necrosome,” the multiprotein complex that triggers tumor necrosis factor (TNF)-induced cell…”
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scPipe: A flexible R/Bioconductor preprocessing pipeline for single-cell RNA-sequencing data by Tian, Luyi, Su, Shian, Dong, Xueyi, Amann-Zalcenstein, Daniela, Biben, Christine, Seidi, Azadeh, Hilton, Douglas J, Naik, Shalin H, Ritchie, Matthew E

“…Single-cell RNA sequencing (scRNA-seq) technology allows researchers to profile the transcriptomes of thousands of cells simultaneously. Protocols that…”
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NLRP1 Inflammasome Activation Induces Pyroptosis of Hematopoietic Progenitor Cells by Masters, Seth L., Gerlic, Motti, Metcalf, Donald, Preston, Simon, Pellegrini, Marc, O’Donnell, Joanne A., McArthur, Kate, Baldwin, Tracey M., Chevrier, Stephane, Nowell, Cameron J., Cengia, Louise H., Henley, Katya J., Collinge, Janelle E., Kastner, Daniel L., Feigenbaum, Lionel, Hilton, Douglas J., Alexander, Warren S., Kile, Benjamin T., Croker, Ben A.

“…Cytopenias are key prognostic indicators of life-threatening infection, contributing to immunosuppression and mortality. Here we define a role for…”
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Suppression of cytokine signaling: The SOCS perspective by Linossi, Edmond M, Babon, Jeffrey J, Hilton, Douglas J, Nicholson, Sandra E

“…Abstract The discovery of the Suppressor of Cytokine Signaling (SOCS) family of proteins has resulted in a significant body of research dedicated to dissecting…”
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SmcHD1, containing a structural-maintenance-of-chromosomes hinge domain, has a critical role in X inactivation by Whitelaw, Emma, Blewitt, Marnie E, Gendrel, Anne-Valerie, Pang, Zhenyi, Sparrow, Duncan B, Whitelaw, Nadia, Craig, Jeffrey M, Apedaile, Anwyn, Hilton, Douglas J, Dunwoodie, Sally L, Brockdorff, Neil, Kay, Graham F

“…X-chromosome inactivation is the mammalian dosage compensation mechanism by which transcription of X-linked genes is equalized between females and males. In an…”
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Haemopedia RNA-seq: a database of gene expression during haematopoiesis in mice and humans by Choi, Jarny, Baldwin, Tracey M, Wong, Mae, Bolden, Jessica E, Fairfax, Kirsten A, Lucas, Erin C, Cole, Rebecca, Biben, Christine, Morgan, Clare, Ramsay, Kerry A, Ng, Ashley P, Kauppi, Maria, Corcoran, Lynn M, Shi, Wei, Wilson, Nick, Wilson, Michael J, Alexander, Warren S, Hilton, Douglas J, de Graaf, Carolyn A

“…Abstract During haematopoiesis, haematopoietic stem cells differentiate into restricted potential progenitors before maturing into the many lineages required…”
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Antennal scales improve signal detection efficiency in moths by Wang, Qike, Shang, Yidan, Hilton, Douglas S., Inthavong, Kiao, Zhang, Dong, Elgar, Mark A.

“…The elaborate bipectinate antennae of male moths are thought to increase their sensitivity to female sex pheromones, and so should be favoured by selection…”
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ChIP-seq analysis reveals distinct H3K27me3 profiles that correlate with transcriptional activity by Young, Matthew D., Willson, Tracy A., Wakefield, Matthew J., Trounson, Evelyn, Hilton, Douglas J., Blewitt, Marnie E., Oshlack, Alicia, Majewski, Ian J.

“…Transcriptional control is dependent on a vast network of epigenetic modifications. One epigenetic mark of particular interest is tri-methylation of lysine 27…”
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Short-term particulate matter contamination severely compromises insect antennal olfactory perception by Wang, Qike, Liu, Genting, Yan, Liping, Xu, Wentian, Hilton, Douglas J., Liu, Xianhui, Pei, Wenya, Li, Xinyu, Wu, Jinbiao, Zhao, Haifeng, Zhang, Dong, Elgar, Mark A.

“…The consequences of sub-lethal levels of ambient air pollution are underestimated for insects, for example, the accumulation of particulate matter on sensory…”
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Dissecting the molecular control of Interleukin 6 signaling using the M1 cell line by Morris, Rhiannon, Hilton, Douglas J., Jarratt, Andrew, Babon, Jeffrey J.

“…Interleukin 6 is the classical member of the IL-6 family of cytokines which triggers activation of the JAK/STAT signaling cascade in cells. IL-6 is a…”
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The role of suppressors of cytokine signaling (SOCS) proteins in regulation of the immune response by Alexander, Warren S, Hilton, Douglas J

“…Cytokines are an integral component of the adaptive and innate immune responses. The signaling pathways triggered by the engagement of cytokines with their…”
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Membrane budding is a major mechanism of in vivo platelet biogenesis by Potts, Kathryn S, Farley, Alison, Dawson, Caleb A, Rimes, Joel, Biben, Christine, de Graaf, Carolyn, Potts, Margaret A, Stonehouse, Olivia J, Carmagnac, Amandine, Gangatirkar, Pradnya, Josefsson, Emma C, Anttila, Casey, Amann-Zalcenstein, Daniela, Naik, Shalin, Alexander, Warren S, Hilton, Douglas J, Hawkins, Edwin D, Taoudi, Samir

“…How platelets are produced by megakaryocytes in vivo remains controversial despite more than a century of investigation. Megakaryocytes readily produce…”
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Inhibitors of Cytokine Signal Transduction by Wormald, Samuel, Hilton, Douglas J.

“…Cytokines are secreted proteins that regulate diverse biological functions by binding to receptors at the cell surface to activate complex signal transduction…”
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Mpl expression on megakaryocytes and platelets is dispensable for thrombopoiesis but essential to prevent myeloproliferation by Ng, Ashley P., Kauppi, Maria, Metcalf, Donald, Hyland, Craig D., Josefsson, Emma C., Lebois, Marion, Zhang, Jian-Guo, Baldwin, Tracey M., Di Rago, Ladina, Hilton, Douglas J., Alexander, Warren S.

“…Thrombopoietin (TPO) acting via its receptor, the cellular homologue of the myeloproliferative leukemia virus oncogene (Mpl), is the major cytokine regulator…”
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Alpha Interferon Induces Long-Lasting Refractoriness of JAK-STAT Signaling in the Mouse Liver through Induction of USP18/UBP43 by Sarasin-Filipowicz, Magdalena, Wang, Xueya, Yan, Ming, Duong, Francois H. T., Poli, Valeria, Hilton, Douglas J., Zhang, Dong-Er, Heim, Markus H.

“…Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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Genome-wide binding and mechanistic analyses of Smchd1-mediated epigenetic regulation by Chen, Kelan, Jiang Hu, Darcy L. Moore, Ruijie Liu, Sarah A. Kessans, Kelsey Breslin, Isabelle S. Lucet, Andrew Keniry, Huei San Leong, Clare L. Parish, Douglas J. Hilton, Richard J. L. F. Lemmers, Silvère M. van der Maarel, Peter E. Czabotar, Renwick C. J. Dobson, Matthew E. Ritchie, Graham F. Kay, James M. Murphy, Marnie E. Blewitt

“…Structural maintenance of chromosomes flexible hinge domain containing 1 (Smchd1) is an epigenetic repressor with described roles in X inactivation and genomic…”
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PU.1 Is Required for the Developmental Progression of Multipotent Progenitors to Common Lymphoid Progenitors by Pang, Swee Heng Milon, de Graaf, Carolyn A, Hilton, Douglas J, Huntington, Nicholas D, Carotta, Sebastian, Wu, Li, Nutt, Stephen L

“…The transcription factor PU.1 is required for the development of mature myeloid and lymphoid cells. Due to this essential role and the importance of PU.1 in…”
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The transcription factor Erg is essential for definitive hematopoiesis and the function of adult hematopoietic stem cells by Kile, Benjamin T, Loughran, Stephen J, Kruse, Elizabeth A, Hacking, Douglas F, de Graaf, Carolyn A, Hyland, Craig D, Willson, Tracy A, Henley, Katya J, Ellis, Sarah, Voss, Anne K, Metcalf, Donald, Hilton, Douglas J, Alexander, Warren S

“…Ets family transcription factors function in mammalian development. Kile and colleagues demonstrate that the Ets family member Erg is essential for definitive…”
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BAF complex-mediated chromatin relaxation is required for establishment of X chromosome inactivation by Keniry, Andrew, Jansz, Natasha, Gearing, Linden J., Wanigasuriya, Iromi, Chen, Joseph, Nefzger, Christian M., Hickey, Peter F., Gouil, Quentin, Liu, Joy, Breslin, Kelsey A., Iminitoff, Megan, Beck, Tamara, Tapia del Fierro, Andres, Whitehead, Lachlan, Jarratt, Andrew, Kinkel, Sarah A., Taberlay, Phillippa C., Willson, Tracy, Pakusch, Miha, Ritchie, Matthew E., Hilton, Douglas J., Polo, Jose M., Blewitt, Marnie E.

“…The process of epigenetic silencing, while fundamentally important, is not yet completely understood. Here we report a replenishable female mouse embryonic…”
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Opposing roles of polycomb repressive complexes in hematopoietic stem and progenitor cells by Majewski, Ian J., Ritchie, Matthew E., Phipson, Belinda, Corbin, Jason, Pakusch, Miha, Ebert, Anja, Busslinger, Meinrad, Koseki, Haruhiko, Hu, Yifang, Smyth, Gordon K., Alexander, Warren S., Hilton, Douglas J., Blewitt, Marnie E.

“…Polycomb group (PcG) proteins are transcriptional repressors with a central role in the establishment and maintenance of gene expression patterns during…”
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