Search Results - "Hiltensperger, Michael"

Current and future concepts for the generation and application of genetically engineered CAR-T and TCR-T cells by Hiltensperger, Michael, Krackhardt, Angela M

“…Adoptive cell therapy (ACT) has seen a steep rise of new therapeutic approaches in its immune-oncology pipeline over the last years. This is in great part due…”
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Blimp1 Prevents Methylation of Foxp3 and Loss of Regulatory T Cell Identity at Sites of Inflammation by Garg, Garima, Muschaweckh, Andreas, Moreno, Helena, Vasanthakumar, Ajithkumar, Floess, Stefan, Lepennetier, Gildas, Oellinger, Rupert, Zhan, Yifan, Regen, Tommy, Hiltensperger, Michael, Peter, Christian, Aly, Lilian, Knier, Benjamin, Palam, Lakshmi Reddy, Kapur, Reuben, Kaplan, Mark H., Waisman, Ari, Rad, Roland, Schotta, Gunnar, Huehn, Jochen, Kallies, Axel, Korn, Thomas

“…Foxp3+ regulatory T (Treg) cells restrict immune pathology in inflamed tissues; however, an inflammatory environment presents a threat to Treg cell identity…”
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Harnessing naturally occurring mutations for T-cell therapy: a potential new avenue to enhance treatment efficacy by Hiltensperger, Michael, Ruland, Jürgen, Schober, Kilian

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Proteogenomic analysis reveals RNA as a source for tumor-agnostic neoantigen identification by Tretter, Celina, de Andrade Krätzig, Niklas, Pecoraro, Matteo, Lange, Sebastian, Seifert, Philipp, von Frankenberg, Clara, Untch, Johannes, Zuleger, Gabriela, Wilhelm, Mathias, Zolg, Daniel P., Dreyer, Florian S., Bräunlein, Eva, Engleitner, Thomas, Uhrig, Sebastian, Boxberg, Melanie, Steiger, Katja, Slotta-Huspenina, Julia, Ochsenreither, Sebastian, von Bubnoff, Nikolas, Bauer, Sebastian, Boerries, Melanie, Jost, Philipp J., Schenck, Kristina, Dresing, Iska, Bassermann, Florian, Friess, Helmut, Reim, Daniel, Grützmann, Konrad, Pfütze, Katrin, Klink, Barbara, Schröck, Evelin, Haller, Bernhard, Kuster, Bernhard, Mann, Matthias, Weichert, Wilko, Fröhling, Stefan, Rad, Roland, Hiltensperger, Michael, Krackhardt, Angela M.

“…Systemic pan-tumor analyses may reveal the significance of common features implicated in cancer immunogenicity and patient survival. Here, we provide a…”
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Author Correction: Proteogenomic analysis reveals RNA as a source for tumor-agnostic neoantigen identification by Tretter, Celina, de Andrade Krätzig, Niklas, Pecoraro, Matteo, Lange, Sebastian, Seifert, Philipp, von Frankenberg, Clara, Untch, Johannes, Zuleger, Gabriela, Wilhelm, Mathias, Zolg, Daniel P., Dreyer, Florian S., Bräunlein, Eva, Engleitner, Thomas, Uhrig, Sebastian, Boxberg, Melanie, Steiger, Katja, Slotta-Huspenina, Julia, Ochsenreither, Sebastian, von Bubnoff, Nikolas, Bauer, Sebastian, Boerries, Melanie, Jost, Philipp J., Schenck, Kristina, Dresing, Iska, Bassermann, Florian, Friess, Helmut, Reim, Daniel, Grützmann, Konrad, Pfütze, Katrin, Klink, Barbara, Schröck, Evelin, Haller, Bernhard, Kuster, Bernhard, Mann, Matthias, Weichert, Wilko, Fröhling, Stefan, Rad, Roland, Hiltensperger, Michael, Krackhardt, Angela M.

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Association of the retinal vasculature, intrathecal immunity, and disability in multiple sclerosis by Noll, Christina, Hiltensperger, Michael, Aly, Lilian, Wicklein, Rebecca, Afzali, Ali Maisam, Mardin, Christian, Gasperi, Christiane, Berthele, Achim, Hemmer, Bernhard, Korn, Thomas, Knier, Benjamin

“…Background Optical coherence tomography angiography (OCT-A) is a novel technique allowing non-invasive assessment of the retinal vasculature. During relapsing…”
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Role of IL-6 in the commitment of T cell subsets by Korn, Thomas, Hiltensperger, Michael

“…[Display omitted] •IL-6 is a non-redundant differentiation factor for Th17 cells and Tfh cells.•The induction of ROR-γt+ Treg cells in the lamina propria…”
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The Interleukin (IL)-23/T helper (Th)17 Axis in Experimental Autoimmune Encephalomyelitis and Multiple Sclerosis by Hiltensperger, Michael, Korn, Thomas

“…T helper (Th)17 cells are responsible for host defense against fungi and certain extracellular bacteria but have also been reported to play a role in a variety…”
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Myeloid-derived suppressor cells control B cell accumulation in the central nervous system during autoimmunity by Knier, Benjamin, Hiltensperger, Michael, Sie, Christopher, Aly, Lilian, Lepennetier, Gildas, Engleitner, Thomas, Garg, Garima, Muschaweckh, Andreas, Mitsdörffer, Meike, Koedel, Uwe, Höchst, Bastian, Knolle, Percy, Gunzer, Matthias, Hemmer, Bernhard, Rad, Roland, Merkler, Doron, Korn, Thomas

“…Polymorphonuclear myeloid-derived suppressor cells (PMN-MDSCs) have been characterized in the context of malignancies. Here we show that PMN-MDSCs can restrain…”
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Skin and gut imprinted helper T cell subsets exhibit distinct functional phenotypes in central nervous system autoimmunity by Hiltensperger, Michael, Beltrán, Eduardo, Kant, Ravi, Tyystjärvi, Sofia, Lepennetier, Gildas, Domínguez Moreno, Helena, Bauer, Isabel J., Grassmann, Simon, Jarosch, Sebastian, Schober, Kilian, Buchholz, Veit R., Kenet, Selin, Gasperi, Christiane, Öllinger, Rupert, Rad, Roland, Muschaweckh, Andreas, Sie, Christopher, Aly, Lilian, Knier, Benjamin, Garg, Garima, Afzali, Ali M., Gerdes, Lisa Ann, Kümpfel, Tania, Franzenburg, Sören, Kawakami, Naoto, Hemmer, Bernhard, Busch, Dirk H., Misgeld, Thomas, Dornmair, Klaus, Korn, Thomas

“…Multidimensional single-cell analyses of T cells have fueled the debate about whether there is extensive plasticity or ‘mixed’ priming of helper T cell subsets…”
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Skin and gut imprinted T helper cell subsets exhibit distinct functional phenotypes in central nervous system autoimmunity by Hiltensperger, Michael, Beltrán, Eduardo, Kant, Ravi, Tyystjärvi, Sofia, Lepennetier, Gildas, Moreno, Helena Domínguez, Bauer, Isabel J., Grassmann, Simon, Jarosch, Sebastian, Schober, Kilian, Buchholz, Veit R., Kenet, Selin, Gasperi, Christiane, Öllinger, Rupert, Rad, Roland, Muschaweckh, Andreas, Sie, Christopher, Aly, Lilian, Knier, Benjamin, Garg, Garima, Afzali, Ali M., Gerdes, Lisa Ann, Kümpfel, Tania, Franzenburg, Sören, Kawakami, Naoto, Hemmer, Bernhard, Busch, Dirk H., Misgeld, Thomas, Dornmair, Klaus, Korn, Thomas

“…Multidimensional single cell-analyses of T cells have fueled the debate about either extensive plasticity or “mixed” priming of T helper cell subsets in vivo…”
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Rapamycin rescues loss of function in blood-brain barrier-interacting Tregs by Baeten, Paulien, Hamad, Ibrahim, Hoeks, Cindy, Hiltensperger, Michael, Van Wijmeersch, Bart, Popescu, Veronica, Aly, Lilian, Somers, Veerle, Korn, Thomas, Kleinewietfeld, Markus, Hellings, Niels, Broux, Bieke

“…In autoimmunity, FOXP3+ Tregs skew toward a proinflammatory, nonsuppressive phenotype and are, therefore, unable to control the exaggerated autoimmune…”
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Spontaneous translocation of a human enterococcal gut pathobiont drives systemic autoimmunity by Vieira, Silvio Manfredo, Hiltensperger, Michael, Kumar, Varun, Zegarra-Ruiz, Daniel, Dehner, Carina Anja, Barbieri, Andrea, Jain, Dhanpat, Goodman, Andrew, Kriegel, Martin A.

“…Abstract Host-microbiota interactions in the pathogenesis of autoimmunity remain poorly understood. Here, we show that a gut commensal, Enterococcus…”
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Myeloid-derived suppressor cells control B cell accumulation in the CNS during autoimmunity by Knier, Benjamin, Hiltensperger, Michael, Sie, Christopher, Aly, Lilian, Lepennetier, Gildas, Engleitner, Thomas, Garg, Garima, Muschaweckh, Andreas, Mitsdörffer, Meike, Koedel, Uwe, Höchst, Bastian, Knolle, Percy, Gunzer, Matthias, Hemmer, Bernhard, Rad, Roland, Merkler, Doron, Korn, Thomas

“…PMN-MDSCs (polymorphonuclear myeloid-derived suppressor cells) have been characterized in the context of malignancies. Here we found that PMN-MDSCs had the…”
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Gut commensal dependence of autoreactivity and Th17 cells in systemic autoimmunity (MUC9P.740) by Manfredo Vieira, SILVIO, Ruff, William, Hiltensperger, Michael, Yu, Andrew, Goodman, Andrew, Kriegel, Martin

“…Abstract Infectious triggers have been implicated in transient antiphospholipid antibody production but the cause of chronic antiphospholipid syndrome (APS) is…”
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Spontaneous Translocation of a Gut Pathobiont Drives Autoimmunity that is Preventable by Intramuscular Vaccination by Vieira, Silvio Manfredo, Hiltensperger, Michael, Kumar, Varun, Dehner, Carina, Zegarra-Ruiz, Daniel, Ruff, William, Khan, Nafeesa, Goodman, Andrew, Kriegel, Martin A

“…Abstract The gut microbiota contributes to the pathogenesis of autoimmunity. The mechanisms and sites of host-microbiota interactions are, however, largely…”
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