Search Results - "Hillyer, Christopher D"

Escape from neutralizing antibodies by SARS-CoV-2 spike protein variants by Weisblum, Yiska, Schmidt, Fabian, Zhang, Fengwen, DaSilva, Justin, Poston, Daniel, Lorenzi, Julio Cc, Muecksch, Frauke, Rutkowska, Magdalena, Hoffmann, Hans-Heinrich, Michailidis, Eleftherios, Gaebler, Christian, Agudelo, Marianna, Cho, Alice, Wang, Zijun, Gazumyan, Anna, Cipolla, Melissa, Luchsinger, Larry, Hillyer, Christopher D, Caskey, Marina, Robbiani, Davide F, Rice, Charles M, Nussenzweig, Michel C, Hatziioannou, Theodora, Bieniasz, Paul D

“…Neutralizing antibodies elicited by prior infection or vaccination are likely to be key for future protection of individuals and populations against…”
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Noninfectious Serious Hazards of Transfusion by Hendrickson, Jeanne E., Hillyer, Christopher D.

“…As infectious complications from blood transfusion have decreased because of improved donor questionnaires and sophisticated infectious disease blood…”
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Impairment of human terminal erythroid differentiation by histone deacetylase 5 deficiency by Wang, Yaomei, Li, Wei, Schulz, Vincent P., Zhao, Huizhi, Qu, Xiaoli, Qi, Qian, Cheng, Yong, Guo, Xinhua, Zhang, Shijie, Wei, Xin, Liu, Donghao, Yazdanbakhsh, Karina, Hillyer, Christopher D., Mohandas, Narla, Chen, Lixiang, Gallagher, Patrick G., An, Xiuli

“…Histone deacetylases (HDACs) are a group of enzymes that catalyze the removal of acetyl groups from histone and nonhistone proteins. HDACs have been shown to…”
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Distinct roles for TET family proteins in regulating human erythropoiesis by Yan, Hongxia, Wang, Yaomei, Qu, Xiaoli, Li, Jie, Hale, John, Huang, Yumin, An, Chao, Papoin, Julien, Guo, Xinhua, Chen, Lixiang, Kang, Qiaozhen, Li, Wei, Schulz, Vincent P., Gallagher, Patrick G., Hillyer, Christopher D., Mohandas, Narla, An, Xiuli

“…The ten-eleven translocation (TET) family of proteins plays important roles in a wide range of biological processes by oxidizing 5-methylcytosine (5mC) to…”
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A Unique Epigenomic Landscape Defines Human Erythropoiesis by Schulz, Vincent P., Yan, Hongxia, Lezon-Geyda, Kimberly, An, Xiuli, Hale, John, Hillyer, Christopher D., Mohandas, Narla, Gallagher, Patrick G.

“…Mammalian erythropoiesis yields a highly specialized cell type, the mature erythrocyte, evolved to meet the organismal needs of increased oxygen-carrying…”
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COVID19 antibody detection using lateral flow assay tests in a cohort of convalescent plasma donors by Ragnesola, Brett, Jin, Daniel, Lamb, Christopher C, Shaz, Beth H, Hillyer, Christopher D, Luchsinger, Larry L

“…Abstract Objective COVID19 has caused a global and ongoing pandemic. The need for population seroconversion data is apparent to monitor and respond to the…”
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TET2 deficiency leads to stem cell factor–dependent clonal expansion of dysfunctional erythroid progenitors by Qu, Xiaoli, Zhang, Shijie, Wang, Shihui, Wang, Yaomei, Li, Wei, Huang, Yumin, Zhao, Huizhi, Wu, Xiuyun, An, Chao, Guo, Xinhua, Hale, John, Li, Jie, Hillyer, Christopher D., Mohandas, Narla, Liu, Jing, Yazdanbakhsh, Karina, Vinchi, Francesca, Chen, Lixiang, Kang, Qiaozhen, An, Xiuli

“…Myelodysplastic syndromes (MDSs) are clonal hematopoietic stem cell disorders characterized by ineffective hematopoiesis. Anemia is the defining cytopenia of…”
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Dose of Prophylactic Platelet Transfusions and Prevention of Hemorrhage by Slichter, Sherrill J, Kaufman, Richard M, Assmann, Susan F, McCullough, Jeffrey, Triulzi, Darrell J, Strauss, Ronald G, Gernsheimer, Terry B, Ness, Paul M, Brecher, Mark E, Josephson, Cassandra D, Konkle, Barbara A, Woodson, Robert D, Ortel, Thomas L, Hillyer, Christopher D, Skerrett, Donna L, McCrae, Keith R, Sloan, Steven R, Uhl, Lynne, George, James N, Aquino, Victor M, Manno, Catherine S, McFarland, Janice G, Hess, John R, Leissinger, Cindy, Granger, Suzanne

“…The use of platelet transfusions to prevent bleeding in patients with thrombocytopenia due to chemotherapy or other causes of marrow suppression is widespread,…”
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Transfusion-related acute lung injury: from bedside to bench and back by Shaz, Beth H., Stowell, Sean R., Hillyer, Christopher D.

“…Over the past 60 years, the transfusion medicine community has attained significant knowledge regarding transfusion-related acute lung injury (TRALI) through…”
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How did we rapidly implement a convalescent plasma program? by Budhai, Alexandra, Wu, Annie A., Hall, Lucette, Strauss, Donna, Paradiso, Sarai, Alberigo, Jill, Hillyer, Christopher D., Jett, Betsy, Tobian, Aaron A. R., Bloch, Evan M., Sachais, Bruce S., Shaz, Beth H.

“…ABSTRACT Since the beginning of the COVID‐19 pandemic, the use of convalescent plasma as a possible treatment has been explored. Here we describe our…”
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Lysine succinylation precisely controls normal erythropoiesis by Hu, Bin, Gong, Han, Nie, Ling, Zhang, Ji, Li, Yanan, Liu, Dandan, Zhang, Huifang, Zhang, Haihang, Han, Lu, Yang, Chaoying, Li, Maohua, Xu, Wenwen, Nakamura, Yukio, Shi, Lihong, Ye, Mao, Hillyer, Christopher D, Mohandas, Narla, Liang, Long, Sheng, Yue, Liu, Jing

“…Lysine succinylation (Ksu) has recently emerged as a protein modification that regulates diverse functions in various biological processes. However, the…”
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Increased number of coagulation products in relationship to red blood cell products transfused improves mortality in trauma patients by Shaz, Beth H., Dente, Christopher J., Nicholas, Jeffrey, MacLeod, Jana B., Young, Andrew N., Easley, Kirk, Ling, Qiang, Harris, Robert S., Hillyer, Christopher D.

“…BACKGROUND: Recent data from military and civilian centers suggest that mortality is decreased in massive transfusion patients by increasing the transfusion…”
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Seroprevalence of anti-SARS-CoV-2 antibodies in a cohort of New York City metro blood donors using multiple SARS-CoV-2 serological assays: Implications for controlling the epidemic and "Reopening" by Jin, Daniel K, Nesbitt, Daniel J, Yang, Jenny, Chen, Haidee, Horowitz, Julie, Jones, Marcus, Vandergaast, Rianna, Carey, Timothy, Reiter, Samantha, Russell, Stephen J, Kyratsous, Christos, Hooper, Andrea, Hamilton, Jennifer, Ferreira, Manuel, Deng, Sarah, Straus, Donna, Baras, Aris, Hillyer, Christopher D, Luchsinger, Larry L

“…Projections of the stage of the Severe Acute Respiratory Syndrome-Coronavirus-2 (SARS-CoV-2) pandemic and local, regional and national public health policies…”
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The effect of previous pregnancy and transfusion on HLA alloimmunization in blood donors: implications for a transfusion-related acute lung injury risk reduction strategy by Triulzi, Darrell J., Kleinman, Steven, Kakaiya, Ram M., Busch, Michael. P., Norris, Philip J., Steele, Whitney R., Glynn, Simone A., Hillyer, Christopher D., Carey, Patricia, Gottschall, Jerome L., Murphy, Edward L., Rios, Jorge A., Ness, Paul M., Wright, David J., Carrick, Danielle, Schreiber, George B.

“…BACKGROUND: Antibodies to human leukocyte antigens (HLA) in donated blood have been implicated as a cause of transfusion‐related acute lung injury (TRALI). A…”
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Deubiquitylase USP7 regulates human terminal erythroid differentiation by stabilizing GATA1 by Liang, Long, Peng, Yuanliang, Zhang, Jieying, Zhang, Yibin, Roy, Mridul, Han, Xu, Xiao, Xiaojuan, Sun, Shuming, Liu, Hong, Nie, Ling, Kuang, Yijin, Zhu, Zesen, Deng, Jinghui, Xia, Yang, Sankaran, Vijay G, Hillyer, Christopher D, Mohandas, Narla, Ye, Mao, An, Xiuli, Liu, Jing

“…Ubiquitination is an enzymatic post-translational modification that affects protein fate. The ubiquitin-proteasome system (UPS) was first discovered in…”
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Spotlight on pathogenesis of TRALI: HNA-3a (CTL2) antibodies by Storch, Emily K., Hillyer, Christopher D., Shaz, Beth H.

“…Human neutrophil antigen-3a (HNA-3a) antibodies contained in donor plasma can result in severe, sometimes fatal transfusion-related acute lung injury (TRALI)…”
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Discovery of Highly Potent Small Molecule Pan-Coronavirus Fusion Inhibitors by Curreli, Francesca, Chau, Kent, Tran, Thanh-Thuy, Nicolau, Isabella, Ahmed, Shahad, Das, Pujita, Hillyer, Christopher D, Premenko-Lanier, Mary, Debnath, Asim K

“…The unprecedented pandemic of COVID-19, caused by a novel coronavirus, SARS-CoV-2, and its highly transmissible variants, led to massive human suffering,…”
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Do Red Cell Transfusions Increase the Risk of Necrotizing Enterocolitis in Premature Infants? by Josephson, Cassandra D., MD, Wesolowski, Agnieszka, MD, Bao, Gaobin, MSPH, Sola-Visner, Martha C., MD, Dudell, Golde, MD, Castillejo, Marta-Inés, BSN, Shaz, Beth H., MD, Easley, Kirk A., MS, Hillyer, Christopher D., MD, Maheshwari, Akhil, MD

“…Objective To test the hypothesis that red blood cell (RBC) transfusions increase the risk of necrotizing enterocolitis (NEC) in premature infants, we…”
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SF3B1 deficiency impairs human erythropoiesis via activation of p53 pathway: implications for understanding of ineffective erythropoiesis in MDS by Huang, Yumin, Hale, John, Wang, Yaomei, Li, Wei, Zhang, Shijie, Zhang, Jieying, Zhao, Huizhi, Guo, Xinhua, Liu, Jing, Yan, Hongxia, Yazdanbakhsh, Karina, Huang, Gang, Hillyer, Christopher D, Mohandas, Narla, Chen, Lixiang, Sun, Ling, An, Xiuli

“…SF3B1 is a core component of splicing machinery. Mutations in SF3B1 are frequently found in myelodysplastic syndromes (MDS), particularly in patients with…”
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Discovery of Highly Potent Fusion Inhibitors with Potential Pan-Coronavirus Activity That Effectively Inhibit Major COVID-19 Variants of Concern (VOCs) in Pseudovirus-Based Assays by Curreli, Francesca, Ahmed, Shahad, Victor, Sofia M B, Drelich, Aleksandra, Panda, Siva S, Altieri, Andrea, Kurkin, Alexander V, Tseng, Chien-Te K, Hillyer, Christopher D, Debnath, Asim K

“…We report the discovery of several highly potent small molecules with low-nM potency against severe acute respiratory syndrome coronavirus (SARS-CoV; lowest…”
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