Circulating Endothelial Cells in Renal Transplant Recipients

Circulating Endothelial Cells in Renal Transplant Recipients

Circulating endothelial cells (CECs) are a marker of endothelial injury and endothelial dysfunction. We measured CECs in 95 patients with functioning renal transplants at risk of premature cardiovascular (CV) disease and in normal control subjects. We were unable to demonstrate consistent relationsh...

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Bibliographic Details
Published in:Transplantation proceedings Vol. 37; no. 5; pp. 2387 - 2390
Main Authors: Mohamed, A.S., Thomson, J., McDonald, K.J., Hillyard, D.Z., Mark, P.B., Elliott, H.L., Jardine, A.G.
Format: Journal Article
Language:English
Published: United States Elsevier Inc 01-06-2005
Subjects:
Adult
Age Distribution
Aged
Cardiovascular Diseases - blood
Cardiovascular Diseases - epidemiology
Endothelial Cells - pathology
Endothelial Cells - physiology
Female
Humans
Kidney Transplantation - pathology
Kidney Transplantation - physiology
Male
Middle Aged
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Summary:Circulating endothelial cells (CECs) are a marker of endothelial injury and endothelial dysfunction. We measured CECs in 95 patients with functioning renal transplants at risk of premature cardiovascular (CV) disease and in normal control subjects. We were unable to demonstrate consistent relationships between CEC levels and conventional CV risk factors in transplant recipients. However, CEC levels were increased in patients with a history of rejection. We conclude that CECs are of little use as a marker of CV risk in this population but may be a useful marker to monitor allograft rejection.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:0041-1345
1873-2623
DOI:10.1016/j.transproceed.2005.03.126