Search Results - "Hillman, Kristine M"
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CRISPR-Cas13d screens identify KILR, a breast cancer risk-associated lncRNA that regulates DNA replication and repair
Published in Molecular cancer (15-05-2024)“…Long noncoding RNAs (lncRNAs) have surpassed the number of protein-coding genes, yet the majority have no known function. We previously discovered 844 lncRNAs…”
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Chromatin interactome mapping at 139 independent breast cancer risk signals
Published in Genome Biology (07-01-2020)“…Genome-wide association studies have identified 196 high confidence independent signals associated with breast cancer susceptibility. Variants within these…”
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3
Long-Range Modulation of PAG1 Expression by 8q21 Allergy Risk Variants
Published in American journal of human genetics (06-08-2015)“…The gene(s) whose expression is regulated by allergy risk variants is unknown for many loci identified through genome-wide association studies. Addressing this…”
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4
eQTL Colocalization Analyses Identify NTN4 as a Candidate Breast Cancer Risk Gene
Published in American journal of human genetics (01-10-2020)“…Breast cancer genome-wide association studies (GWASs) have identified 150 genomic risk regions containing more than 13,000 credible causal variants (CCVs). The…”
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Long Noncoding RNAs CUPID1 and CUPID2 Mediate Breast Cancer Risk at 11q13 by Modulating the Response to DNA Damage
Published in American journal of human genetics (03-08-2017)“…Breast cancer risk is strongly associated with an intergenic region on 11q13. We have previously shown that the strongest risk-associated SNPs fall within a…”
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Endometriosis risk alleles at 1p36.12 act through inverse regulation of CDC42 and LINC00339
Published in Human molecular genetics (15-11-2016)“…Genome-wide association studies (GWAS) have identified markers within the WNT4 region on chromosome 1p36.12 showing consistent and strong association with…”
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7
Targeting VEGF with LNA-stabilized G-rich oligonucleotide for efficient breast cancer inhibition
Published in Chemical communications (Cambridge, England) (11-06-2015)“…In this study, we investigated the efficacy of an LNA (locked nucleic acid)-modified DNA aptamer named RNV66 targeting VEGF against various breast cancer cell…”
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Non-coding RNAs underlie genetic predisposition to breast cancer
Published in Genome Biology (07-01-2020)“…Genetic variants identified through genome-wide association studies (GWAS) are predominantly non-coding and typically attributed to altered regulatory elements…”
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Fine-Scale Mapping of the 5q11.2 Breast Cancer Locus Reveals at Least Three Independent Risk Variants Regulating MAP3K1
Published in American journal of human genetics (08-01-2015)“…Genome-wide association studies (GWASs) have revealed SNP rs889312 on 5q11.2 to be associated with breast cancer risk in women of European ancestry. In an…”
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10
Porphyromonas loveana sp. nov., isolated from the oral cavity of Australian marsupials
Published in International journal of systematic and evolutionary microbiology (01-10-2016)“…An obligatory anaerobic, Gram-stain-negative coccobacillus with black-pigmented colonies was isolated from the oral cavity of selected Australian marsupial…”
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Multiple independent variants at the TERT locus are associated with telomere length and risks of breast and ovarian cancer
Published in Nature genetics (01-04-2013)“…Stig Bojesen, Georgia Chenevix-Trench, Alison Dunning and colleagues report common variants at the TERT-CLPTM1L locus associated with mean telomere length…”
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Breast cancer risk variants at 6q25 display different phenotype associations and regulate ESR1, RMND1 and CCDC170
Published in Nature genetics (01-04-2016)“…Alison Dunning, Stacey Edwards and colleagues analyze 3,872 common variants across the ESR1 locus in 118,816 women. They find five independent variants within…”
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Functional Variants at the 11q13 Risk Locus for Breast Cancer Regulate Cyclin D1 Expression through Long-Range Enhancers
Published in American journal of human genetics (04-04-2013)“…Analysis of 4,405 variants in 89,050 European subjects from 41 case-control studies identified three independent association signals for…”
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Evidence that breast cancer risk at the 2q35 locus is mediated through IGFBP5 regulation
Published in Nature communications (23-09-2014)“…GWAS have identified a breast cancer susceptibility locus on 2q35. Here we report the fine mapping of this locus using data from 101,943 subjects from 50…”
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Evidence that the 5p12 Variant rs10941679 Confers Susceptibility to Estrogen-Receptor-Positive Breast Cancer through FGF10 and MRPS30 Regulation
Published in American journal of human genetics (06-10-2016)“…Genome-wide association studies (GWASs) have revealed increased breast cancer risk associated with multiple genetic variants at 5p12. Here, we report the fine…”
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Fine-mapping of the HNF1B multicancer locus identifies candidate variants that mediate endometrial cancer risk
Published in Human molecular genetics (01-03-2015)“…Common variants in the hepatocyte nuclear factor 1 homeobox B (HNF1B) gene are associated with the risk of Type II diabetes and multiple cancers. Evidence to…”
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A Common Variant at the 14q32 Endometrial Cancer Risk Locus Activates AKT1 through YY1 Binding
Published in American journal of human genetics (02-06-2016)“…A recent meta-analysis of multiple genome-wide association and follow-up endometrial cancer case-control datasets identified a novel genetic risk locus for…”
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Germline polymorphisms in an enhancer of PSIP1 are associated with progression-free survival in epithelial ovarian cancer
Published in Oncotarget (09-02-2016)“…Women with epithelial ovarian cancer (EOC) are usually treated with platinum/taxane therapy after cytoreductive surgery but there is considerable…”
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Publisher Correction: Evidence that breast cancer risk at the 2q35 locus is mediated through IGFBP5 regulation
Published in Nature communications (10-04-2018)“…This corrects the article DOI: 10.1038/ncomms5999…”
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