Search Results - "Hilliard, Jamese"

Staphylococcus aureus alpha toxin suppresses effective innate and adaptive immune responses in a murine dermonecrosis model by Tkaczyk, Christine, Hamilton, Melissa M, Datta, Vivekananda, Yang, Xiang Ping, Hilliard, Jamese J, Stephens, Geoffrey L, Sadowska, Agnieszka, Hua, Lei, O'Day, Terrence, Suzich, JoAnn, Stover, Charles Kendall, Sellman, Bret R

“…An optimal host response against Staphylococcus aureus skin and soft tissue infections (SSTI) is dependent on IL-1β and IL-17 mediated abscess formation. Alpha…”
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Efficacy of therapeutically administered gepotidacin in a rabbit model of inhalational anthrax by Hilliard, Jamese J, Jakielaszek, Charles, Mannino, Frank, Hossain, Mohammad, Qian, Lian, Fishman, Cindy, Demons, Samandra, Hershfield, Jeremy, Soffler, Carl, Russo, Riccardo, Henning, Lisa, Novak, Joseph, O'Dwyer, Karen

“…is a Gram-positive Centers for Disease Control and Prevention category "A" biothreat pathogen. Without early treatment, inhalation of anthrax spores with…”
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Efficacy of Intravenously Administered Gepotidacin in Cynomolgus Macaques following a Francisella tularensis Inhalational Challenge by Jakielaszek, Charles, Hilliard, Jamese J, Mannino, Frank, Hossain, Mohammad, Qian, Lian, Fishman, Cindy, Chou, Ying-Liang, Henning, Lisa, Novak, Joseph, Demons, Samandra, Hershfield, Jeremy, O'Dwyer, Karen

“…Francisella tularensis (F. tularensis) is a Centers for Disease Control (CDC) category "A" Gram-negative biothreat pathogen. Inhalation of F. tularensis can…”
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Candida albicans Augments Staphylococcus aureus Virulence by Engaging the Staphylococcal agr Quorum Sensing System by Todd, Olivia A, Fidel, Jr, Paul L, Harro, Janette M, Hilliard, Jamese J, Tkaczyk, Christine, Sellman, Bret R, Noverr, Mairi C, Peters, Brian M

“…and are among the most prevalent nosocomial pathogens that are responsible for severe morbidity and mortality, even with appropriate treatment. Using a murine…”
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Staphylococcus aureus α toxin potentiates opportunistic bacterial lung infections by Cohen, Taylor S, Hilliard, Jamese J, Jones-Nelson, Omari, Keller, Ashley E, O'Day, Terrence, Tkaczyk, Christine, DiGiandomenico, Antonio, Hamilton, Melissa, Pelletier, Mark, Wang, Qun, Diep, Binh An, Le, Vien T M, Cheng, Lily, Suzich, JoAnn, Stover, C Kendall, Sellman, Bret R

“…Broad-spectrum antibiotic use may adversely affect a patient's beneficial microbiome and fuel cross-species spread of drug resistance. Although alternative…”
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The Neutrophilic Response to Pseudomonas Damages the Airway Barrier, Promoting Infection by Klebsiella pneumoniae by Jones-Nelson, Omari, Hilliard, Jamese J, DiGiandomenico, Antonio, Warrener, Paul, Alfaro, Alex, Cheng, Lily, Stover, C Kendall, Cohen, Taylor S, Sellman, Bret R

“…Pseudomonas aeruginosa and Klebsiella pneumoniae are two common gram-negative pathogens that are associated with bacterial pneumonia and can often be isolated…”
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Antibacterial Monoclonal Antibodies Do Not Disrupt the Intestinal Microbiome or Its Function by Jones-Nelson, Omari, Tovchigrechko, Andrey, Glover, Matthew S, Fernandes, Fiona, Rangaswamy, Udaya, Liu, Hui, Tabor, David E, Boyd, Jonathan, Warrener, Paul, Martinez, Jose, Hilliard, Jamese J, Stover, C Ken, Yu, Wen, DAngelo, Gina, Hess, Sonja, Cohen, Taylor S, Sellman, Bret R

“…Antibiotics revolutionized the treatment of infectious diseases; however, it is now clear that broad-spectrum antibiotics alter the composition and function of…”
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Anti-alpha-toxin monoclonal antibody and antibiotic combination therapy improves disease outcome and accelerates healing in a Staphylococcus aureus dermonecrosis model by Hilliard, Jamese J, Datta, Vivekananda, Tkaczyk, Christine, Hamilton, Melissa, Sadowska, Agnieszka, Jones-Nelson, Omari, O'Day, Terrence, Weiss, William J, Szarka, Szabolcs, Nguyen, Vien, Prokai, Laszlo, Suzich, JoAnn, Stover, C Kendall, Sellman, Bret R

“…Alpha-toxin (AT) is a major virulence determinant in Staphylococcus aureus skin and soft tissue infection models. We previously demonstrated that prophylactic…”
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Targeting Alpha Toxin To Mitigate Its Lethal Toxicity in Ferret and Rabbit Models of Staphylococcus aureus Necrotizing Pneumonia by Diep, Binh An, Hilliard, Jamese J, Le, Vien T M, Tkaczyk, Christine, Le, Hoan N, Tran, Vuvi G, Rao, Renee L, Dip, Etyene Castro, Pereira-Franchi, Eliane P, Cha, Paulyn, Jacobson, Scott, Broome, Rosemary, Cheng, Lily I, Weiss, William, Prokai, Laszlo, Nguyen, Vien, Stover, C Ken, Sellman, Bret R

“…The role broad-spectrum antibiotics play in the spread of antimicrobial resistance, coupled with their effect on the healthy microbiome, has led to advances in…”
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Critical Role of Alpha-Toxin and Protective Effects of Its Neutralization by a Human Antibody in Acute Bacterial Skin and Skin Structure Infections by Le, Vien T M, Tkaczyk, Christine, Chau, Sally, Rao, Renee L, Dip, Etyene Castro, Pereira-Franchi, Eliane P, Cheng, Lily, Lee, Sally, Koelkebeck, Holly, Hilliard, Jamese J, Yu, Xiang Qing, Datta, Vivekananda, Nguyen, Vien, Weiss, William, Prokai, Laszlo, O'Day, Terrence, Stover, C Kendall, Sellman, Bret R, Diep, Binh An

“…Methicillin-resistant Staphylococcus aureus (MRSA) causes large-scale epidemics of acute bacterial skin and skin structure infections (ABSSSI) within…”
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Staphylococcus aureus in Non-Cystic Fibrosis Bronchiectasis: Prevalence and Genomic Basis of High Inoculum Beta-Lactam Resistance by Mossman, Alexandra K, Svishchuk, Julianna, Waddell, Barbara Jean M, Izydorczyk, Conrad S, Buckley, Peter T, Hilliard, Jamese J, Al-Ghalith, Gabriel, Zheng, Lingjie, Lynch, Anthony S, Mody, Christopher H, Lisboa, Luiz F, Gregson, Daniel B, Parkins, Michael D

“…Rationale The pathobiology of Staphylococcus aureus in non-cystic fibrosis bronchiectasis (nCFB) is poorly defined. When present at high density or "inoculum",…”
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Efficacy of a New Fluoroquinolone, JNJ-Q2, in Murine Models of Staphylococcus aureus and Streptococcus pneumoniae Skin, Respiratory, and Systemic Infections by FERNANDEZ, Jeffrey, HILLIARD, Jamese J, MORROW, Brian J, MELTON, John L, FLAMM, Robert K, BARRON, Alfred M, SIMON LYNCH, A

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7-(4-Alkylidenylpiperidinyl)-quinolone bacterial topoisomerase inhibitors by Grant, Eugene B., Foleno, Barbara D., Goldschmidt, Raul, Hilliard, Jamese J., Lin, Shu-Chen, Morrow, Brian, Paget, Steven D., Weidner-Wells, Michele A., Xu, Xiaodong, Xu, Xiaoqing, Murray, William V., Bush, Karen, Macielag, Mark J.

“…[Display omitted] Novel antibacterial fluoroquinolone agents bearing a 4-alkylidenylpiperidine 7-position substituent are active against quinolone-susceptible…”
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Comparative Effects of Carbapenems on Bacterial Load and Host Immune Response in a Klebsiella pneumoniae Murine Pneumonia Model by HILLIARD, Jamese J, MELTON, John L, HALL, Leroy, ABBANAT, Darren, FERNANDEZ, Jeffrey, WARD, Christine K, BUNTING, Rachel A, BARRON, A, SIMON LYNCH, A, FLAMM, Robert K

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In Vivo Activity of the Pyrrolopyrazolyl-Substituted Oxazolidinone RWJ-416457 by HILLIARD, Jamese J, FERNANDEZ, Jeffrey, MELTON, John, MACIELAG, Mark J, GOLDSCHMIDT, Raul, BUSH, Karen, ABBANAT, Darren

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In Vivo Activity of Ceftobiprole in Murine Skin Infections Due to Staphylococcus aureus and Pseudomonas aeruginosa by FERNANDEZ, Jeffrey, HILLIARD, Jamese J, ABBANAT, Darren, WENYAN ZHANG, MELTON, John L, SANTORO, Colleen M, FLAMM, Robert K, BUSH, Karen

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Multiple Mechanisms of Action for Inhibitors of Histidine Protein Kinases from Bacterial Two-Component Systems by HILLIARD, J. J, GOLDSCHMIDT, R. M, LICATA, L, BAUM, E. Z, BUSH, K

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Synthesis and antibacterial activity of 7-(1,2,3,4-tetrahydropyrrolo[1,2- a]pyrazin-7-yl) quinolones by Zhu, Bin, Marinelli, Brett A., Goldschmidt, Raul, Foleno, Barbara D., Hilliard, Jamese J., Bush, Karen, Macielag, Mark J.

“…A novel series of 7-(1,2,3,4-tetrahydropyrrolo[1,2- a]pyrazin-7-yl) quinolones has been designed and synthesized in which the heterocyclic side chain is…”
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Synthesis and antibacterial activity of C6-carbazate ketolides by Tennakoon, Manomi A., Henninger, Todd C., Abbanat, Darren, Foleno, Barbara D., Hilliard, Jamese J., Bush, Karen, Macielag, Mark J.

“…A novel series of ketolides containing various heteroaryl groups linked to the macrolide core via a C6-carbazate functionality has been successfully…”
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Identification of a Dithiazoline Inhibitor of Escherichia coli l,d-Carboxypeptidase A by BAUM, Ellen Z, CRESPO-CARBONE, Steven M, FOLENO, Barbara, PENG, Sean, HILLIARD, Jamese J, ABBANAT, Darren, GOLDSCHMIDT, Raul, BUSH, Karen

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