Search Results - "Hilliard, Darryl W."

Discovery of PiragliatinFirst Glucokinase Activator Studied in Type 2 Diabetic Patients by Sarabu, Ramakanth, Bizzarro, Fred T, Corbett, Wendy L, Dvorozniak, Mark T, Geng, Wanping, Grippo, Joseph F, Haynes, Nancy-Ellen, Hutchings, Stanley, Garofalo, Lisa, Guertin, Kevin R, Hilliard, Darryl W, Kabat, Marek, Kester, Robert F, Ka, Wang, Liang, Zhenmin, Mahaney, Paige E, Marcus, Linda, Matschinsky, Franz M, Moore, David, Racha, Jagdish, Radinov, Roumen, Ren, Yi, Qi, Lida, Pignatello, Michael, Spence, Cheryl L, Steele, Thomas, Tengi, John, Grimsby, Joseph

“…Glucokinase (GK) activation as a potential strategy to treat type 2 diabetes (T2D) is well recognized. Compound 1, a glucokinase activator (GKA) lead that we…”
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Allosteric Activators of Glucokinase: Potential Role in Diabetes Therapy by Grimsby, Joseph, Sarabu, Ramakanth, Corbett, Wendy L., Haynes, Nancy-Ellen, Bizzarro, Fred T., Coffey, John W., Guertin, Kevin R., Hilliard, Darryl W., Kester, Robert F., Mahaney, Paige E., Marcus, Linda, Qi, Lida, Spence, Cheryl L., Tengi, John, Magnuson, Mark A., Chu, Chang An, Dvorozniak, Mark T., Matschinsky, Franz M., Grippo, Joseph F.

“…Glucokinase (GK) plays a key role in whole-body glucose homeostasis by catalyzing the phosphorylation of glucose in cells that express this enzyme, such as…”
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Discovery, Structure−Activity Relationships, Pharmacokinetics, and Efficacy of Glucokinase Activator (2R)-3-Cyclopentyl-2-(4-methanesulfonylphenyl)-N-thiazol-2-yl-propionamide (RO0281675) by Haynes, Nancy-Ellen, Corbett, Wendy L, Bizzarro, Fred T, Guertin, Kevin R, Hilliard, Darryl W, Holland, George W, Kester, Robert F, Mahaney, Paige E, Qi, Lida, Spence, Cheryl L, Tengi, John, Dvorozniak, Mark T, Railkar, Aruna, Matschinsky, Franz M, Grippo, Joseph F, Grimsby, Joseph, Sarabu, Ramakanth

“…Glucokinase (GK) is a glucose sensor that couples glucose metabolism to insulin release. The important role of GK in maintaining glucose homeostasis is…”
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