Search Results - "Hillhouse, Andrew"
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STAT3 signaling in myeloid cells promotes pathogenic myelin-specific T cell differentiation and autoimmune demyelination
Published in Proceedings of the National Academy of Sciences - PNAS (10-03-2020)“…Multiple sclerosis (MS) is an autoimmune inflammatory demyelinating disease of the central nervous system. Dysregulation of STAT3, a transcription factor…”
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Comparative Genomics of Three Novel Jumbo Bacteriophages Infecting Staphylococcus aureus
Published in Journal of virology (09-09-2021)“…The majority of previously described Staphylococcus aureus bacteriophages belong to three major groups, namely, P68-like podophages, Twort-like or K-like…”
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Differences in the genome, methylome, and transcriptome do not differentiate isolates of Streptococcus equi subsp. equi from horses with acute clinical signs from isolates of inapparent carriers
Published in PloS one (14-06-2021)“…Streptococcus equi subsp. equi (SEE) is a host-restricted bacterium that causes the common infectious upper respiratory disease known as strangles in horses…”
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4
The role of estrogen signaling in a mouse model of inflammatory bowel disease: a Helicobacter hepaticus model
Published in PloS one (01-04-2014)“…The pathogenesis of inflammatory bowel diseases (IBD), Crohn's disease and ulcerative colitis, is due in part to interactions between the immune system,…”
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Brain region dependent molecular signatures and myelin repair following chronic demyelination
Published in Frontiers in cellular neuroscience (26-04-2023)“…Multiple sclerosis (MS) is the most prevalent demyelinating disease of the central nervous system, characterized by myelin destruction, axonal degeneration,…”
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Impact of E-cig aerosol vaping on fetal and neonatal respiratory development and function
Published in Translational research : the journal of laboratory and clinical medicine (01-08-2022)“…Electronic cigarette (e-cig) use has increased over the past decade, and exposure to e-cig aerosols during pregnancy raises concern for maternal and fetal…”
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A type VII secretion system of Streptococcus gallolyticus subsp. gallolyticus contributes to gut colonization and the development of colon tumors
Published in PLoS pathogens (06-01-2021)“…Streptococcus gallolyticus subspecies gallolyticus (Sgg) has a strong clinical association with colorectal cancer (CRC) and actively promotes the development…”
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Transcriptomic analysis of the honey bee (Apis mellifera) queen spermathecae reveals genes that may be involved in sperm storage after mating
Published in PloS one (2021)“…Honey bee (Apis mellifera) queens have a remarkable organ, the spermatheca, which successfully stores sperm for years after a virgin queen mates. This study…”
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Comparative transcriptome analysis of Peromyscus leucopus and C3H mice infected with the Lyme disease pathogen
Published in Frontiers in cellular and infection microbiology (11-04-2023)“…Lyme disease (LD), the most prevalent tick-borne disease of humans in the Northern Hemisphere, is caused by the spirochetal bacterium of ( ) sensu lato…”
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10
The Assembled Genome of the Stroke-Prone Spontaneously Hypertensive Rat
Published in Hypertension (Dallas, Tex. 1979) (01-01-2023)“…We report the creation and evaluation of a de novo assembly of the genome of the spontaneously hypertensive rat, the most widely used model of human…”
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Host genetic background influences diverse neurological responses to viral infection in mice
Published in Scientific reports (22-09-2017)“…Infection by Theiler’s murine encephalomyelitis virus (TMEV) is a model for neurological outcomes caused by virus infection because it leads to diverse…”
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12
mRatBN7.2: familiar and unfamiliar features of a new rat genome reference assembly
Published in Physiological genomics (01-07-2022)“…Rat genomic tools have been slower to emerge than for those of humans and mice and have remained less thorough and comprehensive. The arrival of a new and…”
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13
Cell-type and fetal-sex-specific targets of prenatal alcohol exposure in developing mouse cerebral cortex
Published in iScience (21-05-2021)“…Prenatal alcohol exposure (PAE) results in cerebral cortical dysgenesis. Single-cell RNA sequencing was performed on murine fetal cerebral cortical cells from…”
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Comparison of whole genome sequences of Streptococcus equi subsp. equi from an outbreak in Texas with isolates from within the region, Kentucky, USA, and other countries
Published in Veterinary microbiology (01-04-2020)“…•Mutations can occur in S. equi isolates within an individual host during an outbreak.•Whole genome sequencing improves understanding of S. equi molecular…”
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Sex differences in the transcriptome of extracellular vesicles secreted by fetal neural stem cells and effects of chronic alcohol exposure
Published in Biology of sex differences (15-04-2023)“…Prenatal alcohol (ethanol) exposure (PAE) results in brain growth restriction, in part, by reprogramming self-renewal and maturation of fetal neural stem cells…”
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Contribution of the Oral and Gastrointestinal Microbiomes to Bloodstream Infections in Leukemia Patients
Published in Microbiology spectrum (15-06-2023)“…Bloodstream infections (BSIs) pose a significant mortality risk for acute myeloid leukemia (AML) patients. It has been previously reported that intestinal…”
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Analysis of Virulence and Antimicrobial Resistance Gene Carriage in Staphylococcus aureus Infections in Equids Using Whole-Genome Sequencing
Published in mSphere (25-08-2021)“…While Staphylococcus aureus is associated with significant morbidity and mortality in equids (horses, donkeys, and mules), few studies have performed…”
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Resilience in Long-Term Viral Infection: Genetic Determinants and Interactions
Published in International journal of molecular sciences (21-10-2021)“…Virus-induced neurological sequelae resulting from infection by Theiler's murine encephalomyelitis virus (TMEV) are used for studying human conditions ranging…”
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Permissiveness to form pluripotent stem cells may be an evolutionarily derived characteristic in Mus musculus
Published in Scientific reports (02-10-2018)“…Mus musculus is the only known species from which embryonic stem cells (ESC) can be isolated under conditions requiring only leukemia inhibitory factor (LIF)…”
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Primary Murine Macrophages as a Tool for Virulence Factor Discovery in Coxiella burnetii
Published in Microbiology spectrum (01-08-2022)“…Coxiella burnetii requires a type IVB secretion system (T4SS) to promote intracellular replication and virulence. We hypothesized that employs its T4SS to…”
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