Search Results - "Hillgartner, F Bradley"

Fibroblast Growth Factor-19, a Novel Factor That Inhibits Hepatic Fatty Acid Synthesis by Bhatnagar, Sushant, Damron, Holly A., Hillgartner, F.Bradley

“…Previous studies have shown that administration of fibroblast growth factor-19 (FGF-19) reverses diabetes, hepatic steatosis, hyperlipidemia, and adipose…”
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Glucagon and Insulin Cooperatively Stimulate Fibroblast Growth Factor 21 Gene Transcription by Increasing the Expression of Activating Transcription Factor 4 by Alonge, Kimberly M., Meares, Gordon P., Hillgartner, F. Bradley

“…Previous studies have shown that glucagon cooperatively interacts with insulin to stimulate hepatic FGF21 gene expression. Here we investigated the mechanism…”
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Glucagon stimulates hepatic FGF21 secretion through a PKA- and EPAC-dependent posttranscriptional mechanism by Cyphert, Holly A, Alonge, Kimberly M, Ippagunta, Siri M, Hillgartner, F Bradley

“…Previous studies have shown that whole body deletion of the glucagon receptor suppresses the ability of starvation to increase hepatic fibroblast growth factor…”
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Activation of the Farnesoid X Receptor Induces Hepatic Expression and Secretion of Fibroblast Growth Factor 21 by Cyphert, Holly A., Ge, Xuemei, Kohan, Alison B., Salati, Lisa M., Zhang, Yanqiao, Hillgartner, F. Bradley

“…Background: The hormone FGF21 is a potent regulator of carbohydrate and lipid metabolism and a promising drug for treating metabolic syndrome. Results:…”
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The mechanism mediating the activation of acetyl-coenzyme A carboxylase-α gene transcription by the liver X receptor agonist T0-901317 by Talukdar, Saswata, Hillgartner, F. Bradley

“…In birds and mammals, agonists of the liver X receptor (LXR) increase the expression of enzymes that make up the fatty acid synthesis pathway. Here, we…”
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Cholic Acid Supplementation of a High-Fat Obesogenic Diet Suppresses Hepatic Triacylglycerol Accumulation in Mice via a Fibroblast Growth Factor 21-Dependent Mechanism by Ippagunta, Siri M, Kharitonenkov, Alexei, Adams, Andrew C, Hillgartner, F Bradley

“…Supplementation of a high-fat obesogenic diet (HFD) with cholic acid (CA) suppresses the development of obesity, insulin resistance, and hepatic steatosis in…”
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Chenodeoxycholic acid suppresses the activation of acetyl-coenzyme A carboxylase-α gene transcription by the liver X receptor agonist T0-901317 by Talukdar, Saswata, Bhatnagar, Sushant, Dridi, Sami, Hillgartner, F. Bradley

“…The therapeutic utility of liver X receptor (LXR) agonists in treating atherosclerosis is limited by an undesired accumulation of triglycerides in the blood…”
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Sterol Regulatory Element-binding Protein-1 Interacts with the Nuclear Thyroid Hormone Receptor to Enhance Acetyl-CoA Carboxylase-α Transcription in Hepatocytes by Yin, Liya, Zhang, Yanqiao, Hillgartner, F. Bradley

“…In previous work, we characterized a 3,5,3′-triiodothyronine response element (T3RE) in acetyl-CoA carboxylase-α (ACCα) promoter 2 that mediated…”
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FAS inhibitor cerulenin reduces food intake and melanocortin receptor gene expression without modulating the other (an)orexigenic neuropeptides in chickens by Dridi, Sami, Ververken, Cedric, Hillgartner, F Bradley, Arckens, Lutgarde, Lutgarde, Arckens, Van der Gucht, Estel, Cnops, Lieselotte, Decuypere, Eddy, Buyse, Johan

“…Cerulenin, a natural fatty acid synthase (FAS) inhibitor, and its synthetic analog C75 are hypothesized to alter the metabolism of neurons in the hypothalamus…”
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Role of CCAAT/enhancer-binding protein, histone acetylation, and coactivator recruitment in the regulation of malic enzyme transcription by thyroid hormone by Yin, Liya, Wang, Yutong, Dridi, Sami, Vinson, Charles, Hillgartner, F. Bradley

“…In chick embryo hepatocytes, activation of malic enzyme gene transcription by triiodothyronine (T3) is mediated by a T3 response unit (T3RU) that contains five…”
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Physiological and molecular mechanisms involved in nutritional regulation of fatty acid synthesis by Hillgartner, F B, Salati, L M, Goodridge, A G

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Starvation and feeding a high-carbohydrate, low-fat diet regulate the expression sterol regulatory element-binding protein-1 in chickens by Zhang, Yanqiao, Hillgartner, F Bradley

“…In mammalian liver, the mature form of sterol regulatory element-binding protein-1c (SREBP-1c) is an important activator of a wide array of genes involved in…”
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Role of Sterol Regulatory Element Binding Proteins in the Regulation of Gαi2 Expression in Cultured Atrial Cells by Park, Ho-Jin, Begley, Ulrike, Kong, Dequan, Yu, Haiyan, Yin, Liya, Hillgartner, F Bradley, Osborne, Timothy F, Galper, Jonas B

“…We have previously demonstrated that growth of embryonic chick atrial cells in medium supplemented with lipoprotein-depleted serum (LPDS) resulted in a…”
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The Homeodomain Proteins PBX and MEIS1 Are Accessory Factors That Enhance Thyroid Hormone Regulation of the Malic Enzyme Gene in Hepatocytes by Wang, Yutong, Yin, Liya, Hillgartner, F. Bradley

“…Triiodothyronine (T3) stimulates a robust increase (>40-fold) in transcription of the malic enzyme gene in chick embryo hepatocytes. Previous work has shown…”
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Alterations in nutritional status regulate acetyl-CoA carboxylase expression in avian liver by a transcriptional mechanism by Hillgartner, F B, Charron, T, Chesnut, K A

“…Feeding previously starved chicks with a high-carbohydrate, low-fat diet stimulates a 9-fold increase in both the rate of synthesis of acetyl-CoA carboxylase…”
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Glucose stimulates transcription of fatty acid synthase and malic enzyme in avian hepatocytes by Hillgartner, F B, Charron, T

“…Transcription of fatty acid synthase (FAS) and malic enzyme (ME) in avian liver is low during starvation or feeding a low-carbohydrate, high-fat diet and high…”
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Chicken ovalbumin upstream-promoter transcription factor and E-box-binding proteins enhance thyroid-hormone responsiveness of the malic enzyme gene in avian hepatocytes by Wang, Yutong, Zhang, Yanqiao, Hillgartner, F Bradley

“…In chick embryo hepatocytes (CEH), stimulation of malic enzyme transcription by 3,3',5-tri-iodothyronine (T3) is mediated by a liver-specific and T3-inducible…”
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Fibroblast Growth Factor-19, a Novel Factor That Inhibits Hepatic Fatty Acid SynthesisS by Bhatnagar, Sushant, Damron, Holly A., Hillgartner, F. Bradley

“…Previous studies have shown that administration of fibroblast growth factor-19 (FGF-19) reverses diabetes, hepatic steatosis, hyperlipidemia, and adipose…”
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Overexpression of the alpha-thyroid hormone receptor in avian cell lines. Effects on expression of the malic enzyme gene are selective and cell-specific by BRADLEY HILLGARTNER, F, WEIZU CHEN, GOODRIDGE, A. G

“…The role of the alpha-thyroid hormone receptor (TR alpha) in regulation of transcription of the gene for chicken malic enzyme was analyzed in fibroblast cell…”
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SREBP-1 integrates the actions of thyroid hormone, insulin, cAMP, and medium-chain fatty acids on ACCα transcription in hepatocytes by Zhang, Yanqiao, Yin, Liya, Hillgartner, F.Bradley

“…In chick embryo hepatocytes, activation of acetyl-CoA carboxylase-α (ACCα) transcription by 3,5,3′-triiodothyronine (T3) is mediated by a cis-acting regulatory…”
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