Search Results - "Hillen, Hauke S"

Structure of replicating SARS-CoV-2 polymerase by Hillen, Hauke S., Kokic, Goran, Farnung, Lucas, Dienemann, Christian, Tegunov, Dimitry, Cramer, Patrick

“…The new coronavirus severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) uses an RNA-dependent RNA polymerase (RdRp) for the replication of its genome…”
Get full text

Structure and function of SARS-CoV-2 polymerase by Hillen, Hauke S

“…Coronaviruses use an RNA-dependent RNA polymerase (RdRp) to replicate and express their genome. The RdRp associates with additional non-structural proteins…”
Get full text

Mechanism of molnupiravir-induced SARS-CoV-2 mutagenesis by Kabinger, Florian, Stiller, Carina, Schmitzová, Jana, Dienemann, Christian, Kokic, Goran, Hillen, Hauke S., Höbartner, Claudia, Cramer, Patrick

“…Molnupiravir is an orally available antiviral drug candidate currently in phase III trials for the treatment of patients with COVID-19. Molnupiravir increases…”
Get full text

Mechanism of SARS-CoV-2 polymerase stalling by remdesivir by Kokic, Goran, Hillen, Hauke S., Tegunov, Dimitry, Dienemann, Christian, Seitz, Florian, Schmitzova, Jana, Farnung, Lucas, Siewert, Aaron, Höbartner, Claudia, Cramer, Patrick

“…Remdesivir is the only FDA-approved drug for the treatment of COVID-19 patients. The active form of remdesivir acts as a nucleoside analog and inhibits the…”
Get full text

Structural basis of mitochondrial transcription by Hillen, Hauke S., Temiakov, Dmitry, Cramer, Patrick

“…The mitochondrial genome is transcribed by a single-subunit DNA-dependent RNA polymerase (mtRNAP) and its auxiliary factors. Structural studies have elucidated…”
Get full text

Structural Basis of Mitochondrial Transcription Initiation by Hillen, Hauke S., Morozov, Yaroslav I., Sarfallah, Azadeh, Temiakov, Dmitry, Cramer, Patrick

“…Transcription in human mitochondria is driven by a single-subunit, factor-dependent RNA polymerase (mtRNAP). Despite its critical role in both expression and…”
Get full text

Small-molecule inhibitors of human mitochondrial DNA transcription by Bonekamp, Nina A., Peter, Bradley, Hillen, Hauke S., Felser, Andrea, Bergbrede, Tim, Choidas, Axel, Horn, Moritz, Unger, Anke, Di Lucrezia, Raffaella, Atanassov, Ilian, Li, Xinping, Koch, Uwe, Menninger, Sascha, Boros, Joanna, Habenberger, Peter, Giavalisco, Patrick, Cramer, Patrick, Denzel, Martin S., Nussbaumer, Peter, Klebl, Bert, Falkenberg, Maria, Gustafsson, Claes M., Larsson, Nils-Göran

“…Altered expression of mitochondrial DNA (mtDNA) occurs in ageing and a range of human pathologies (for example, inborn errors of metabolism, neurodegeneration…”
Get full text

Structural basis of GTPase-mediated mitochondrial ribosome biogenesis and recycling by Hillen, Hauke S., Lavdovskaia, Elena, Nadler, Franziska, Hanitsch, Elisa, Linden, Andreas, Bohnsack, Katherine E., Urlaub, Henning, Richter-Dennerlein, Ricarda

“…Ribosome biogenesis requires auxiliary factors to promote folding and assembly of ribosomal proteins and RNA. Particularly, maturation of the peptidyl…”
Get full text

Structural Basis of Poxvirus Transcription: Transcribing and Capping Vaccinia Complexes by Hillen, Hauke S., Bartuli, Julia, Grimm, Clemens, Dienemann, Christian, Bedenk, Kristina, Szalay, Aladar A., Fischer, Utz, Cramer, Patrick

“…Poxviruses use virus-encoded multisubunit RNA polymerases (vRNAPs) and RNA-processing factors to generate m7G-capped mRNAs in the host cytoplasm. In the…”
Get full text

Cryo-EM for Structure Determination of Mitochondrial Ribosome Samples by Hillen, Hauke S

“…Single-particle cryoelectron microscopy (cryo-EM) allows structure determination of large macromolecular complexes from conformationally and compositionally…”
Get more information

Structural basis of RNA processing by human mitochondrial RNase P by Bhatta, Arjun, Dienemann, Christian, Cramer, Patrick, Hillen, Hauke S.

“…Human mitochondrial transcripts contain messenger and ribosomal RNAs flanked by transfer RNAs (tRNAs), which are excised by mitochondrial RNase (mtRNase) P and…”
Get full text

The structure of a dimeric form of SARS-CoV-2 polymerase by Jochheim, Florian A., Tegunov, Dimitry, Hillen, Hauke S., Schmitzová, Jana, Kokic, Goran, Dienemann, Christian, Cramer, Patrick

“…The coronavirus SARS-CoV-2 uses an RNA-dependent RNA polymerase (RdRp) to replicate and transcribe its genome. Previous structures of the RdRp revealed a…”
Get full text

Structural and mechanistic basis of RNA processing by protein-only ribonuclease P enzymes by Bhatta, Arjun, Hillen, Hauke S.

“…Ribonuclease P (RNase P) enzymes are responsible for the 5′ processing of tRNA precursors. In addition to the well-characterised ribozyme-based RNase P…”
Get full text

Hierarchical folding of the catalytic core during mitochondrial ribosome biogenesis by Lavdovskaia, Elena, Hillen, Hauke S., Richter-Dennerlein, Ricarda

“…Final maturation steps during ribosome biogenesis require the assistance of assembly and quality control factors to ensure the folding of rRNA and proteins…”
Get full text

Mechanism of Transcription Anti-termination in Human Mitochondria by Hillen, Hauke S., Parshin, Andrey V., Agaronyan, Karen, Morozov, Yaroslav I., Graber, James J., Chernev, Aleksandar, Schwinghammer, Kathrin, Urlaub, Henning, Anikin, Michael, Cramer, Patrick, Temiakov, Dmitry

“…In human mitochondria, transcription termination events at a G-quadruplex region near the replication origin are thought to drive replication of mtDNA by…”
Get full text

The molecular machinery for maturation of primary mtDNA transcripts by Vučković, Ana, Freyer, Christoph, Wredenberg, Anna, Hillen, Hauke S

“…Abstract Human mitochondria harbour a circular, polyploid genome (mtDNA) encoding 11 messenger RNAs (mRNAs), two ribosomal RNAs (rRNAs) and 22 transfer RNAs…”
Get full text

Structure of the multi-subunit chloroplast RNA polymerase by do Prado, Paula F V, Ahrens, Frederik M, Liebers, Monique, Ditz, Noah, Braun, Hans-Peter, Pfannschmidt, Thomas, Hillen, Hauke S

“…Chloroplasts contain a dedicated genome that encodes subunits of the photosynthesis machinery. Transcription of photosynthesis genes is predominantly carried…”
Get more information

Structural Basis of Poxvirus Transcription: Vaccinia RNA Polymerase Complexes by Grimm, Clemens, Hillen, Hauke S., Bedenk, Kristina, Bartuli, Julia, Neyer, Simon, Zhang, Qian, Hüttenhofer, Alexander, Erlacher, Matthias, Dienemann, Christian, Schlosser, Andreas, Urlaub, Henning, Böttcher, Bettina, Szalay, Aladar A., Cramer, Patrick, Fischer, Utz

“…Poxviruses encode a multisubunit DNA-dependent RNA polymerase (vRNAP) that carries out viral gene expression in the host cytoplasm. We report cryo-EM…”
Get full text

Correction to: Lost in promiscuity? An evolutionary and biochemical evaluation of HSD10 function in cardiolipin metabolism by Wohlfarter, Yvonne, Eidelpes, Reiner, Yu, Ryan D., Sailer, Sabrina, Koch, Jakob, Karall, Daniela, Scholl-Bürgi, Sabine, Amberger, Albert, Hillen, Hauke S., Zschocke, Johannes, Keller, Markus A.

Get full text

Lost in promiscuity? An evolutionary and biochemical evaluation of HSD10 function in cardiolipin metabolism by Wohlfarter, Yvonne, Eidelpes, Reiner, Yu, Ryan D., Sailer, Sabrina, Koch, Jakob, Karall, Daniela, Scholl-Bürgi, Sabine, Amberger, Albert, Hillen, Hauke S., Zschocke, Johannes, Keller, Markus A.

“…Multifunctional proteins are challenging as it can be difficult to confirm pathomechanisms associated with disease-causing genetic variants. The human…”
Get full text