Search Results - "Hillegass, L M"

Reperfusion increases neutrophils and leukotriene B4 receptor binding in rat focal ischemia by Barone, F C, Schmidt, D B, Hillegass, L M, Price, W J, White, R F, Feuerstein, G Z, Clark, R K, Lee, E V, Griswold, D E, Sarau, H M

“…Neutrophils are critically involved with ischemia and reperfusion injury in many tissues but have not been studied under conditions of reperfusion after focal…”
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Polymorphonuclear leukocyte infiltration into cerebral focal ischemic tissue: myeloperoxidase activity assay and histologic verification by Barone, F C, Hillegass, L M, Price, W J, White, R F, Lee, E V, Feuerstein, G Z, Sarau, H M, Clark, R K, Griswold, D E

“…Two different techniques were utilized to identify the infiltration of polymorphonuclear leukocytes (PMN) into cerebral tissue following focal ischemia:…”
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ARDS-like lung injury produced by endotoxin in platelet-activating factor-primed rats by Rabinovici, R, Bugelski, P J, Esser, K M, Hillegass, L M, Vernick, J, Feuerstein, G

“…We recently reported that the combined administration of lipopolysaccharide (LPS) and platelet-activating factor (PAF) in rats, at doses that are completely…”
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Role of complement in endotoxin/platelet-activating factor-induced lung injury by Rabinovici, R, Yeh, CG, Hillegass, LM, Griswold, DE, DiMartino, MJ, Vernick, J, Fong, KL, Feuerstein, G

“…C receptor-1 is a protein involved in the regulation of C3 and C5-convertases. Recombinant human soluble C receptor-1 has recently been produced and shown to…”
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Temporal relation between neutrophil accumulation and myocardial reperfusion injury by Smith, 3rd, E F, Egan, J W, Bugelski, P J, Hillegass, L M, Hill, D E, Griswold, D E

“…Infiltration of polymorphonuclear leukocytes (PMN) is associated with the progression of myocardial infarction and reperfusion injury. However, little is known…”
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Priming by Platelet-Activating Factor of Endotoxin-Induced Lung Injury and Cardiovascular Shock by Rabinovici, Reuven, Esser, Klaus M, Lysko, Paul G, Yue, Tian-Li, Griswold, Don E, Hillegass, Leonard M, Bugelski, Peter J, Hallenbeck, John M, Feuerstein, Giora

“…Platelet-activating factor (PAF) is a glycerophospholipid known for its unusual potent vasoactive and proinflammatory activities. The present study examined…”
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Tumor necrosis factor-alpha mediates endotoxin-induced lung injury in platelet activating factor-primed rats by Rabinovici, R, Bugelski, P J, Esser, K M, Hillegass, L M, Griswold, D E, Vernick, J, Feuerstein, G

“…We have reported recently that lipopolysaccharide endotoxin and platelet activating factor cooperate in priming relationships to elicit lung microvascular…”
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Evaluation of human cytokine production and effects of pharmacological agents in a heterologous system in vivo by Griswold, D.E., Hillegass, L.M., O'Leary-Bartus, J., Lee, J.C., Laydon, J.T., Torphy, T.J.

“…The ability of human monocytes adoptively transferred into the peritoneal cavity of BALB c mice to produce tumor necrosis factor-α (TNF) and interleukin 1β…”
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Reduction of myocardial reperfusion injury with human soluble complement receptor type 1 (BRL 55730) by Smith, 3rd, E F, Griswold, D E, Egan, J W, Hillegass, L M, Smith, R A, Hibbs, M J, Gagnon, R C

“…This study was designed to evaluate the cardioprotective effects of a solubilized human complement receptor, sCR1, in the rat subjected to myocardial…”
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Induction of plasma exudation and inflammatory cell infiltration by leukotriene C4 and leukotriene B4 in mouse peritonitis by GRISWOLD, D. E, WEBB, E. F, HILLEGASS, L. M

“…Leukotriene induction of the fluid and cellular phases of the inflammatory response in the mouse was evaluated. Intraperitoneal injection of leukotriene C4…”
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Reduction of myocardial damage and polymorphonuclear leukocyte accumulation following coronary artery occlusion and reperfusion by the thromboxane receptor antagonist BM 13.505 by Smith, 3rd, E F, Griswold, D E, Egan, J W, Hillegass, L M, DiMartino, M J

“…This study was designed to assess the effect of the thromboxane receptor antagonist, BM 13.505, in limiting myocardial damage and polymorphonuclear leukocyte…”
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Reduction in myocardial ischemic/reperfusion injury and neutrophil accumulation after therapeutic administration of streptokinase by Smith, 3rd, E F, Nichols, A J, Sellers, T S, O'Brien, S R, Griswold, D E, Egan, J W, Hillegass, L M, Vasko, J A, Slivjak, M J, Davis, P A

“…The benefit of thrombolytic agents to reduce myocardial infarct size, improve left ventricular (LV) function, and prolong survival in human subjects is…”
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Differentiation in vivo of classical non-steroidal antiinflammatory drugs from cytokine suppressive antiinflammatory drugs and other pharmacological classes using mouse tumour necrosis factor alpha production by Griswold, D E, Hillegass, L M, Breton, J J, Esser, K M, Adams, J L

“…The stimulation of tumour necrosis factor alpha (TNF alpha) production by lipopolysaccharide (LPS) has been widely used, both in vitro and in vivo, to examine…”
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Assessment of myeloperoxidase activity in whole rat kidney by Hillegass, L M, Griswold, D E, Brickson, B, Albrightson-Winslow, C

“…A method to quantitate myeloperoxidase (MPO) activity from rat whole kidney is described. Polymorphonuclear leukocyte (PMN) infiltration into tissue is a…”
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Tetrahydrothiadiazoloisoquinolines: synthesis and inhibition of phenylethanolamine-N-methyltransferase by GIRARD, G. R, BONDINELL, W. E, HILLEGASS, L. M, HOLDEN, K. G, PENDLETON, R. G, UZINSKAS, I

“…A series of 7,8-fused heterocyclic tetrahydroisoquinolines were synthesized and tested as inhibitors of rabbit adrenal phenylethanolamine-N-methyltransferase…”
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Inhibitors of phenylethanolamine N-methyltransferase and epinephrine biosynthesis. 3. Bis[tetrahydroisoquinoline]s by DeMarinis, R. M, Bryan, W. M, Hillegass, L. M, McDermott, D, Pendleton, R. G

“…7,8-Dichloro-1,2,3,4-tetrahydroisoquinoline (SK&F 64139) is a potent inhibitor of phenylethanolamine N-methyltransferase (IC50 = 10 muM) that may have…”
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Time-related changes in myeloperoxidase activity and leukotriene B4 receptor binding reflect leukocyte influx in cerebral focal stroke by Barone, F C, Hillegass, L M, Tzimas, M N, Schmidt, D B, Foley, J J, White, R F, Price, W J, Feuerstein, G Z, Clark, R K, Griswold, D E

“…In previous studies, we have used histological methods to characterize cellular changes, and validated the use of the myeloperoxidase (MPO) activity assay to…”
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Method for quantification of myocardial infarction and inflammatory cell infiltration in rat cardiac tissue by Griswold, D E, Hillegass, L M, Hill, D E, Egan, J W, Smith, 3rd, E F

“…A method to quantitate both creatine phosphokinase (CPK) and myeloperoxidase (MPO) activity from the same cardiac tissue homogenate preparation is described…”
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Pharmacology of the pyrroloimidazole, SK&F 105809--II. Antiinflammatory activity and inhibition of mediator production in vivo by Griswold, D E, Marshall, P J, Lee, J C, Webb, E F, Hillegass, L M, Wartell, J, Newton, Jr, J, Hanna, N

“…SK&F 105809 [2-(4-methylsulfinylphenyl)-3-(4-pyridyl)- 6,7-dihydro-[5H]-pyrrolo[1,2,a] imidazole] demonstrated unique antiinflammatory activities in murine…”
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Demonstration of nuclear and cytoplasmic fluorescence in brain tissues of schizophrenic and nonschizophrenic patients by Boehme, D H, Cottrell, J C, Dohan, F C, Hillegass, L M

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