Search Results - "Hillcoat, B. L"

A randomized trial of cisplatin versus cisplatin plus methotrexate in advanced cancer of the urothelial tract by Hillcoat, B L, Raghavan, D, Matthews, J, Kefford, R, Yuen, K, Woods, R, Olver, I, Bishop, J, Pearson, B, Coorey, G

“…One hundred eight patients with recurrent or metastatic transitional cell carcinoma of the urothelial tract were randomized to receive cisplatin (C) 80 mg/m2…”
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A pharmacokinetic and phase II study of gallium nitrate in patients with non-small cell lung cancer by WEBSTER, L. K, OLVER, I. N, STOKES, K. H, SEPHTON, R. G, HILLCOAT, B. L, BISHOP, J. F

“…This study investigated the pharmacokinetics and activity of gallium nitrate in non-small cell lung cancer when 700 mg/m2 was given as a 30-min infusion with…”
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The binding of binuclear platinum(II)-terpyridine complexes to DNA by McFadyen, W D, Wakelin, L P, Roos, I A, Hillcoat, B L

“…The binding of platinum (II)-terpyridine complexes to DNA was studied by using equilibrium dialysis. Optical absorption methods were used to measure the…”
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Data recycling and misreading: two potential errors in pooled data from small studies by Hillcoat, B L

“…Data from studies on small numbers of patients are often pooled to obtain more significant numbers with which to estimate response rates to chemotherapy. This…”
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cis-Bis(pyridine)platinum(II) organoamides with unexpected growth inhibition properties and antitumor activity by Webster, Lorraine K, Deacon, Glen B, Buxton, David P, Hillcoat, Brian L, James, Alison M, Roos, Ian A. G, Thomson, Robin J, Wakelin, Laurence P. G, Williams, Tracey L

“…The platinum(II) organoamides [Pt(NRCH2)2L2] (L = pyridine (py), R = p-HC6F4, C6F5,p-IC6F4,p-CIC6F4,p-C6F5C6F4; L = 4-methylpyridine, R = p-HC6F4) and…”
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The changing face of clinical trials in Australia by Hillcoat, B L

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Binuclear platinum (II)-terpyridine complexes. A new class of bifunctional DNA-intercalating agent by McFadyen, W D, Wakelin, L P, Roos, I A, Hillcoat, B L

“…A series of binuclear DNA-binding ligands was prepared by linking two (2,2':6',2"-terpyridine)platinum(II) moieties via alpha omega-dithiols of the type…”
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Lorazepam: a randomized, double-blind, crossover study of a new antiemetic in patients receiving cytotoxic chemotherapy and prochlorperazine by Bishop, J F, Olver, I N, Wolf, M M, Matthews, J P, Long, M, Bingham, J, Hillcoat, B L, Cooper, I A

“…Lorazepam was compared to placebo to assess its control of nausea and vomiting in patients receiving cytotoxic chemotherapy and prochlorperazine. The study…”
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Metallothionein induction in mouse tissues by cis-dichlorodiammineplatinum(II) and its hydrolysis products by Farnworth, P G, Hillcoat, B L, Roos, I A

“…cis-Dichlorodiammineplatinum(II) (cis-DDP) doubled the amount of metallothioneins (MTs) in the livers and kidneys of BALB/c mice when injected i.p. in a single…”
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Clinical response and plasma levels of 5-fluorouracil in patients with colonic cancer treated by drug infusion by Hillcoat, B L, McCulloch, P B, Figueredo, A T, Ehsan, M H, Rosenfeld, J M

“…Concentrations of 5-fluorouracil (FU) were measured in the plasma of patients receiving i.v. infusions of the drug for 5 days as treatment for adenocarcinoma…”
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Determination of 6-mercaptopurine in plasma by mass spectrometry by Rosenfeld, J. M, Taguchi, V. Y, Hillcoat, B. L, Kawai, M

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Phase II trial of VP-16-213 in advanced ovarian carcinoma by Hillcoat, B L, Campbell, J J, Pepperell, R, Quinn, M A, Bishop, J F, Day, A

“…We have reevaluated the effectiveness of VP-16-213 in advanced ovarian carcinoma. Twenty-five patients with measurable disease were treated for 3 days every 2…”
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Pharmacokinetics of unchanged carboplatin (CBDCA) in patients with small cell lung carcinoma by REECE, P. A, BISHOP, J. F, OLVER, I. N, STAFFORD, I, HILLCOAT, B. L, MORSTYN, G

“…The disposition of the cisplatin analogue carboplatin was studied in seven patients with small cell lung cancer. Carboplatin 100 mg/m2 was administered without…”
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Rare diseases and “orphan” drugs by Hlllcoat, Brian L

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Development of a murine gastric distension model for testing the emetic potential of new drugs and efficacy of antiemetics by Olver, I N, Roos, I A, Thomas, K, Hillcoat, B L

“…A small animal model for emesis would allow preclinical testing of antiemetics and new drugs. Mice treated with cisplatinum develop stomachs distended with…”
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Variation of dihydrofolate reductase activity during in vitro and in vivo growth of sublines of L1210 lymphoma by Hillcoat, B L

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"Induction" of dihydrofolate reductase: purification and properties of the "induced" human erythrocyte and leukocyte enzyme and normal bone marrow enzyme by Bertino, J R, Cashmore, A R, Hillcoat, B L

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Pharmacokinetic study of doxifluridine given by 5-day stepped-dose infusion by REECE, P. A, OLVER, I. N, MORRIS, R. G, BISHOP, J. F, GUENTERT, T. W, HILL, H. S, HILLCOAT, B. L

“…Doxifluridine (5'-deoxy-5-fluorouridine, 5'-dFUR) metabolism has been reported to be saturable and associated with a fall in clearance of the drug as the dose…”
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Nonenzymatic exchange of tritium from (5-3H) deoxyuridylate in the thymidylate synthetase assay by Kawai, M, Hillcoat, B L

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Immediate hypersensitivity to mannitol: a potential cause of apparent hypersensitivity to cisplatin by Ackland, S P, Hillcoat, B L

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