Collagen synthesis in cultured myoblasts and myotubes from patients with Duchenne muscular dystrophy

Collagen synthesis was studied in cultured myoblasts and myotubes from 4 patients with Duchenne muscular dystrophy (DMD) and 4 control persons. Incorporation of [3H]proline into collagen of DMD cells and control cells was not significantly different. The same types of collagen, i.e., type I and type...

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Bibliographic Details
Published in:	Journal of the neurological sciences Vol. 82; no. 1-3; p. 271
Main Authors:	de Jong, L, Wolterman, R A, Hillarius, S, Bolhuis, P A
Format:	Journal Article
Language:	English
Published:	Netherlands 01-12-1987
Subjects:	Biopsy Cells, Cultured Collagen - biosynthesis Humans Muscles - cytology Muscles - metabolism Muscular Dystrophies - metabolism Muscular Dystrophies - pathology
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Summary:	Collagen synthesis was studied in cultured myoblasts and myotubes from 4 patients with Duchenne muscular dystrophy (DMD) and 4 control persons. Incorporation of [3H]proline into collagen of DMD cells and control cells was not significantly different. The same types of collagen, i.e., type I and type III were synthesized by myogenic cells from DMD patients and controls. In contrast to others, we could not obtain evidence for an increase in the degree of prolyl hydroxylation in collagen of the DMD muscle cells.
ISSN:	0022-510X
DOI:	10.1016/0022-510X(87)90023-2