Effects of Unilateral High Frequency Stimulation of the Subthalamic Nucleus on Risk-avoidant Behavior in a Partial 6-hydroxydopamine Model of Parkinson's Disease

Deep brain stimulation (DBS) of the subthalamic nucleus (STN) is a well-established treatment for the motor symptoms of Parkinson's disease (PD). While PD is primarily characterized by motor symptoms such as tremor, rigidity, and bradykinesia, it also involves a range of non-motor symptoms, and...

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Published in:	Journal of integrative neuroscience Vol. 23; no. 4; p. 84
Main Authors:	Hillan, Sydney G, Asp, Anders J, Pramanik, Leena B, Mukerjee, Aarushi A, Mulder, Carter B, Lujan, Wendy D, Silvernail, Jodi L, Chang, Su-Youne, Boschen, Suelen L, Lujan, J Luis
Format:	Journal Article
Language:	English
Published:	Singapore IMR Press 19-04-2024
Subjects:	6-hydroxydopamine Animals Anxiety - etiology Anxiety - physiopathology Avoidance Learning - physiology Behavior, Animal - physiology Deep Brain Stimulation Disease Models, Animal Male Oxidopamine - pharmacology Parkinson Disease - physiopathology Parkinson Disease - therapy parkinson's disease Parkinsonian Disorders - physiopathology Parkinsonian Disorders - therapy Rats Rats, Sprague-Dawley risk-avoidance Subthalamic Nucleus risk-avoidance 6-hydroxydopamine Parkinson's disease subthalamic nucleus deep brain stimulation
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Summary:	Deep brain stimulation (DBS) of the subthalamic nucleus (STN) is a well-established treatment for the motor symptoms of Parkinson's disease (PD). While PD is primarily characterized by motor symptoms such as tremor, rigidity, and bradykinesia, it also involves a range of non-motor symptoms, and anxiety is one of the most common. The relationship between PD and anxiety is complex and can be a result of both pathological neural changes and the psychological and emotional impacts of living with a chronic progressive condition. Managing anxiety in PD is critical for improving the patients' quality of life. However, patients undergoing STN DBS can occasionally experience increased anxiety. This study investigates changes in risk-avoidant behavior following STN DBS in a pre-motor animal model of PD under chronic and acute unilateral high frequency stimulation. No significant changes in risk-avoidant behaviors were observed in rats who underwent STN DBS compared with sham stimulation controls. Chronic stimulation prevented sensitization in the elevated zero maze. These results suggest that unilateral stimulation of the STN may have minimal effects on risk-avoidant behaviors in PD. However, additional research is required to fully understand the mechanisms responsible for changes in anxiety during STN DBS for PD.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 Author Contributions SGH, AJA, SLB, SYC, and JLL designed research; SGH, AAM, CBM, WDL, JLS, SLB performed research; SGH, LBP, AAM, CBM analyzed data; SGH, LBP, AJA, SLB, SYC, JLL wrote the paper. All authors contributed to editorial changes in the manuscript. All authors read and approved the final manuscript. All authors have participated sufficiently in the work and agreed to be accountable for all aspects of the work.
ISSN:	0219-6352
DOI:	10.31083/j.jin2304084