Search Results - "Hill, Stephen J."

Molecular Pharmacology of VEGF-A Isoforms: Binding and Signalling at VEGFR2 by Peach, Chloe J, Mignone, Viviane W, Arruda, Maria Augusta, Alcobia, Diana C, Hill, Stephen J, Kilpatrick, Laura E, Woolard, Jeanette

“…Vascular endothelial growth factor-A (VEGF-A) is a key mediator of angiogenesis, signalling via the class IV tyrosine kinase receptor family of VEGF Receptors…”
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NanoBRET Approaches to Study Ligand Binding to GPCRs and RTKs by Stoddart, Leigh A., Kilpatrick, Laura E., Hill, Stephen J.

“…Recent advances in the development of fluorescent ligands for G-protein-coupled receptors (GPCRs) and receptor tyrosine kinase receptors (RTKs) have…”
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Community guidelines for GPCR ligand bias: IUPHAR review 32 by Kolb, Peter, Kenakin, Terry, Alexander, Stephen P. H., Bermudez, Marcel, Bohn, Laura M., Breinholt, Christian S., Bouvier, Michel, Hill, Stephen J., Kostenis, Evi, Martemyanov, Kirill A., Neubig, Rick R., Onaran, H. Ongun, Rajagopal, Sudarshan, Roth, Bryan L., Selent, Jana, Shukla, Arun K., Sommer, Martha E., Gloriam, David E.

“…GPCRs modulate a plethora of physiological processes and mediate the effects of one‐third of FDA‐approved drugs. Depending on which ligand activates a…”
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Application of BRET to monitor ligand binding to GPCRs by Stoddart, Leigh A, Johnstone, Elizabeth K M, Wheal, Amanda J, Goulding, Joëlle, Robers, Matthew B, Machleidt, Thomas, Wood, Keith V, Hill, Stephen J, Pfleger, Kevin D G

“…Bioluminescence resonance energy transfer, from the substrate of a luciferase fused with a G protein–coupled receptor to a fluorescent dye covalently linked to…”
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Fluorescence‐ and bioluminescence‐based approaches to study GPCR ligand binding by Stoddart, Leigh A, White, Carl W, Nguyen, Kim, Hill, Stephen J, Pfleger, Kevin D G

“…Ligand binding is a vital component of any pharmacologist's toolbox and allows the detailed investigation of how a molecule binds to its receptor. These…”
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COVID-19-Induced Myocarditis: Pathophysiological Roles of ACE2 and Toll-like Receptors by Pannucci, Patrizia, Jefferson, Sophie R, Hampshire, Jonathan, Cooper, Samantha L, Hill, Stephen J, Woolard, Jeanette

“…The clinical manifestations of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection responsible for coronavirus disease 2019 (COVID-19)…”
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The biodegradation of crude oil in the deep ocean by Prince, Roger C., Nash, Gordon W., Hill, Stephen J.

“…Oil biodegradation at a simulated depth of 1500m was studied in a high-pressure apparatus at 5°C, using natural seawater with its indigenous microbes, and 3ppm…”
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Characterisation of IL-23 receptor antagonists and disease relevant mutants using fluorescent probes by Lay, Charles S., Isidro-Llobet, Albert, Kilpatrick, Laura E., Craggs, Peter D., Hill, Stephen J.

“…Association of single nucleotide polymorphisms in the IL-23 receptor with several auto-inflammatory diseases, led to the heterodimeric receptor and its…”
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Fluorescently tagged nanobodies and NanoBRET to study ligand-binding and agonist-induced conformational changes of full-length EGFR expressed in living cells by Comez, Dehan, Glenn, Jacqueline, Anbuhl, Stephanie M, Heukers, Raimond, Smit, Martine J, Hill, Stephen J, Kilpatrick, Laura E

“…The Epidermal Growth Factor Receptor is a member of the Erb receptor tyrosine kinase family. It binds several ligands including EGF, betacellulin (BTC) and…”
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Role of the Renin-Angiotensin-Aldosterone and Kinin-Kallikrein Systems in the Cardiovascular Complications of COVID-19 and Long COVID by Cooper, Samantha L, Boyle, Eleanor, Jefferson, Sophie R, Heslop, Calum R A, Mohan, Pirathini, Mohanraj, Gearry G J, Sidow, Hamza A, Tan, Rory C P, Hill, Stephen J, Woolard, Jeanette

“…Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) is the virus responsible for the COVID-19 pandemic. Patients may present as asymptomatic or…”
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Transactivation of G protein-coupled receptors (GPCRs) and receptor tyrosine kinases (RTKs): Recent insights using luminescence and fluorescence technologies by Kilpatrick, Laura E., Hill, Stephen J.

“…Alterations in signalling due to bidirectional transactivation of G protein-coupled receptor (GPCRs) and receptor tyrosine kinases (RTKs) are well established…”
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G‐protein‐coupled receptors: past, present and future by Hill, Stephen J

“…The G‐protein‐coupled receptor (GPCR) family represents the largest and most versatile group of cell surface receptors. Drugs active at these receptors have…”
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Development of novel fluorescent histamine H1-receptor antagonists to study ligand-binding kinetics in living cells by Stoddart, Leigh A., Vernall, Andrea J., Bouzo-Lorenzo, Monica, Bosma, Reggie, Kooistra, Albert J., de Graaf, Chris, Vischer, Henry F., Leurs, Rob, Briddon, Stephen J., Kellam, Barrie, Hill, Stephen J.

“…The histamine H 1 -receptor (H 1 R) is an important mediator of allergy and inflammation. H 1 R antagonists have particular clinical utility in allergic…”
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Fecal source tracking and eDNA profiling in an urban creek following an extreme rain event by Staley, Zachery R., Chuong, Jun Dennis, Hill, Stephen J., Grabuski, Josey, Shokralla, Shadi, Hajibabaei, Mehrdad, Edge, Thomas A.

“…Fecal contamination of recreational waters (i.e. lakes, rivers, beaches) poses an on-going problem for environmental and public health. Heavy rainfall can…”
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Transgenic Enrichment of Cardiomyocytes From Human Embryonic Stem Cells by Anderson, David, Self, Tim, Mellor, Ian R, Goh, Gareth, Hill, Stephen J, Denning, Chris

“…To realize the full scientific and clinical potential of human embryonic stem cell (hESC)-cardiomyocytes, strategies to overcome the high degree of…”
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The use of fluorescence correlation spectroscopy to characterize the molecular mobility of fluorescently labelled G protein-coupled receptors by Kilpatrick, Laura E, Hill, Stephen J

“…The membranes of living cells have been shown to be highly organized into distinct microdomains, which has spatial and temporal consequences for the…”
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Pharmacology under the microscope: the use of fluorescence correlation spectroscopy to determine the properties of ligand–receptor complexes by Briddon, Stephen J, Hill, Stephen J

“…Recent years have revealed a high degree of structural organisation in the way in which cell-surface receptors and their associated signalling complexes…”
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A novel fluorescent histamine H1 receptor antagonist demonstrates the advantage of using fluorescence correlation spectroscopy to study the binding of lipophilic ligands by Rose, Rachel H, Briddon, Stephen J, Hill, Stephen J

“…BACKGROUND AND PURPOSE Fluorescent ligands facilitate the study of ligand–receptor interactions at the level of single cells and individual receptors. Here, we…”
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Investigation of Receptor Heteromers Using NanoBRET Ligand Binding by Johnstone, Elizabeth K M, See, Heng B, Abhayawardana, Rekhati S, Song, Angela, Rosengren, K Johan, Hill, Stephen J, Pfleger, Kevin D G

“…Receptor heteromerization is the formation of a complex involving at least two different receptors with pharmacology that is distinct from that exhibited by…”
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Quantitative profiling of nucleotides and related phosphate-containing metabolites in cultured mammalian cells by liquid chromatography tandem electrospray mass spectrometry by Cordell, Rebecca L., Hill, Stephen J., Ortori, Catharine A., Barrett, David A.

“…A method has been developed for the quantitative profiling of over twenty nucleotides and related phosphorylated species using ion-pair reversed-phase liquid…”
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