Search Results - "Hill, R Blake"

Mitochondria-targeted drugs stimulate mitophagy and abrogate colon cancer cell proliferation by Boyle, Kathleen A., Van Wickle, Jonathan, Hill, R. Blake, Marchese, Adriano, Kalyanaraman, Balaraman, Dwinell, Michael B.

“…Mutations in the KRAS proto-oncogene are present in 50% of all colorectal cancers and are increasingly associated with chemotherapeutic resistance to frontline…”
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Mitochondrial regulation of diabetic vascular disease: an emerging opportunity by Widlansky, Michael E., Hill, R. Blake

“…Diabetes-related vascular complication rates remain unacceptably high despite guideline-based medical therapies that are significantly more effective in…”
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Mitochondrial Fission Protein 1: Emerging Roles in Organellar Form and Function in Health and Disease by Ihenacho, Ugochukwu Kelvin, Meacham, Kelsey A, Harwig, Megan Cleland, Widlansky, Michael E, Hill, R Blake

“…Mitochondrial fission protein 1 (Fis1) was identified in yeast as being essential for mitochondrial division or fission and subsequently determined to mediate…”
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The variable domain from dynamin‐related protein 1 promotes liquid–liquid phase separation that enhances its interaction with cardiolipin‐containing membranes by Posey, Ammon E., Ross, Kyle A., Bagheri, Mehran, Lanum, Elizabeth N., Khan, Misha A., Jennings, Christine E., Harwig, Megan C., Kennedy, Nolan W., Hilser, Vincent J., Harden, James L., Hill, R. Blake

“…Dynamins are an essential superfamily of mechanoenzymes that remodel membranes and often contain a “variable domain” important for regulation. For the…”
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A Lethal de Novo Mutation in the Middle Domain of the Dynamin-related GTPase Drp1 Impairs Higher Order Assembly and Mitochondrial Division by Chang, Chuang-Rung, Manlandro, Cara Marie, Arnoult, Damien, Stadler, Julia, Posey, Ammon E., Hill, R. Blake, Blackstone, Craig

“…Mitochondria dynamically fuse and divide within cells, and the proper balance of fusion and fission is necessary for normal mitochondrial function, morphology,…”
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Resistance of Dynamin-related Protein 1 Oligomers to Disassembly Impairs Mitophagy, Resulting in Myocardial Inflammation and Heart Failure by Cahill, Thomas J., Leo, Vincenzo, Kelly, Matthew, Stockenhuber, Alexander, Kennedy, Nolan W., Bao, Leyuan, Cereghetti, Grazia, Harper, Andrew R., Czibik, Gabor, Lao, Chunyan, Bellahcene, Mohamed, Steeples, Violetta, Ghaffari, Safar, Yavari, Arash, Mayer, Alice, Poulton, Joanna, Ferguson, David J.P., Scorrano, Luca, Hettiarachchi, Nishani T., Peers, Chris, Boyle, John, Hill, R. Blake, Simmons, Alison, Watkins, Hugh, Dear, T. Neil, Ashrafian, Houman

“…We have reported previously that a missense mutation in the mitochondrial fission gene Dynamin-related protein 1 (Drp1) underlies the Python mouse model of…”
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SRCP1 Conveys Resistance to Polyglutamine Aggregation by Santarriaga, Stephanie, Haver, Holly N., Kanack, Adam J., Fikejs, Alicia S., Sison, Samantha L., Egner, John M., Bostrom, Jonathan R., Seminary, Emily R., Hill, R. Blake, Link, Brian A., Ebert, Allison D., Scaglione, K. Matthew

“…The polyglutamine (polyQ) diseases are a group of nine neurodegenerative diseases caused by the expansion of a polyQ tract that results in protein aggregation…”
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Development and Validation of 2D Difference Intensity Analysis for Chemical Library Screening by Protein‐Detected NMR Spectroscopy by Egner, John M., Jensen, Davin R., Olp, Michael D., Kennedy, Nolan W., Volkman, Brian F., Peterson, Francis C., Smith, Brian C., Hill, R. Blake

“…An academic chemical screening approach was developed by using 2D protein‐detected NMR, and a 352‐chemical fragment library was screened against three…”
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Mitochondrial fission proteins regulate programmed cell death in yeast by Fannjiang, Yihru, Cheng, Wen-Chih, Lee, Sarah J, Qi, Bing, Pevsner, Jonathan, McCaffery, J Michael, Hill, R Blake, Basañez, Gorka, Hardwick, J Marie

“…The possibility that single-cell organisms undergo programmed cell death has been questioned in part because they lack several key components of the mammalian…”
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Anti-apoptotic Bcl-2 Family Proteins Disassemble Ceramide Channels by Siskind, Leah J., Feinstein, Laurence, Yu, Tingxi, Davis, Joseph S., Jones, David, Choi, Jinna, Zuckerman, Jonathan E., Tan, Wenzhi, Hill, R. Blake, Hardwick, J. Marie, Colombini, Marco

“…Early in mitochondria-mediated apoptosis, the mitochondrial outer membrane becomes permeable to proteins that, when released into the cytosol, initiate the…”
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The cytosolic domain of Fis1 binds and reversibly clusters lipid vesicles by Wells, Robert C, Hill, R Blake

“…Every lipid membrane fission event involves the association of two apposing bilayers, mediated by proteins that can promote membrane curvature, fusion and…”
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Synchronous effects of targeted mitochondrial complex I inhibitors on tumor and immune cells abrogate melanoma progression by AbuEid, Mahmoud, McAllister, Donna M., McOlash, Laura, Harwig, Megan Cleland, Cheng, Gang, Drouillard, Donovan, Boyle, Kathleen A., Hardy, Micael, Zielonka, Jacek, Johnson, Bryon D., Hill, R. Blake, Kalyanaraman, Balaraman, Dwinell, Michael B.

“…Metabolic heterogeneity within the tumor microenvironment promotes cancer cell growth and immune suppression. We determined the impact of mitochondria-targeted…”
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Molecular Motor Dnm1 Synergistically Induces Membrane Curvature To Facilitate Mitochondrial Fission by Lee, Michelle W, Lee, Ernest Y, Lai, Ghee Hwee, Kennedy, Nolan W, Posey, Ammon E, Xian, Wujing, Ferguson, Andrew L, Hill, R. Blake, Wong, Gerard C. L

“…Dnm1 and Fis1 are prototypical proteins that regulate yeast mitochondrial morphology by controlling fission, the dysregulation of which can result in…”
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A Designed "Nested" Dimer of Cyanovirin-N Increases Antiviral Activity by Woodrum, Brian W, Maxwell, Jason, Allen, Denysia M, Wilson, Jennifer, Krumpe, Lauren R H, Bobkov, Andrey A, Hill, R Blake, Kibler, Karen V, O'Keefe, Barry R, Ghirlanda, Giovanna

“…Cyanovirin-N (CV-N) is an antiviral lectin with potent activity against enveloped viruses, including HIV. The mechanism of action involves high affinity…”
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Direct Binding of the Dynamin-like GTPase, Dnm1, to Mitochondrial Dynamics Protein Fis1 Is Negatively Regulated by the Fis1 N-terminal Arm by Wells, Robert C., Picton, Lora K., Williams, Sarah C.P., Tan, Frederick J., Hill, R. Blake

“…Recruitment of a dynamin-like GTPase (Drp1/Dlp1/Dnm1) to membranes requires the mitochondrial dynamics protein Fis1. Mdv1 has been proposed to act as an…”
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Human Fis1 directly interacts with Drp1 in an evolutionarily conserved manner to promote mitochondrial fission by Nolden, Kelsey A., Harwig, Megan C., Hill, R. Blake

“…Mitochondrial fission protein 1 (Fis1) and dynamin-related protein 1 (Drp1) are the only two proteins evolutionarily conserved for mitochondrial fission, and…”
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The Putative Drp1 Inhibitor mdivi-1 Is a Reversible Mitochondrial Complex I Inhibitor that Modulates Reactive Oxygen Species by Bordt, Evan A., Clerc, Pascaline, Roelofs, Brian A., Saladino, Andrew J., Tretter, László, Adam-Vizi, Vera, Cherok, Edward, Khalil, Ahmed, Yadava, Nagendra, Ge, Shealinna X., Francis, T. Chase, Kennedy, Nolan W., Picton, Lora K., Kumar, Tanya, Uppuluri, Sruti, Miller, Alexandrea M., Itoh, Kie, Karbowski, Mariusz, Sesaki, Hiromi, Hill, R. Blake, Polster, Brian M.

“…Mitochondrial fission mediated by the GTPase dynamin-related protein 1 (Drp1) is an attractive drug target in numerous maladies that range from heart disease…”
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A conserved, noncanonical insert in FIS1 mediates TBC1D15 and DRP1 recruitment for mitochondrial fission by Ihenacho, Ugochukwu K, Toro, Rafael, Mansour, Rana H, Hill, R Blake

“…Mitochondrial fission protein 1 (FIS1) is conserved in all eukaryotes, yet its function in metazoans is thought divergent. Structure-based sequence alignments…”
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Role of Conserved Cysteines in the Alphavirus E3 Protein by PARROTT, Megan M, SITARSKI, Sarah A, ARNOLD, Randy J, PICTON, Lora K, BLAKE HILL, R, MUKHOPADHYAY, Suchetana

“…Article Usage Stats Services JVI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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Solution Structure of α2D, a Nativelike de Novo Designed Protein by Hill, R. Blake, DeGrado, William F

“…De novo protein design provides an attractive means for testing and refining the principles governing the stability and tertiary structure of proteins. We…”
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