Inhibitory control deficits in rats with ventral hippocampal lesions

Two experiments are reported in which rats with selective hippocampal lesions were tested on 2 prefrontal-dependent tasks. In Experiment 1, we compared the effects of lesions of the ventral hippocampus (vHC), dorsal hippocampus (dHC), and sham control surgery on the 5-choice reaction time task. Wher...

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Bibliographic Details
Published in:	Cerebral cortex (New York, N.Y. 1991) Vol. 23; no. 6; pp. 1396 - 1409
Main Authors:	Abela, Andrew R, Dougherty, Stephen D, Fagen, Erin D, Hill, Carolyn J R, Chudasama, Y
Format:	Journal Article
Language:	English
Published:	United States 01-06-2013
Subjects:	Analysis of Variance Animals Attention - drug effects Attention - physiology Choice Behavior - drug effects Choice Behavior - physiology Citalopram - pharmacology Discrimination (Psychology) - drug effects Discrimination (Psychology) - physiology Dopamine Uptake Inhibitors - pharmacology Dose-Response Relationship, Drug Food Preferences - drug effects Food Preferences - physiology Hippocampus - injuries Hippocampus - physiology Impulsive Behavior - chemically induced Impulsive Behavior - physiopathology Inhibition (Psychology) Male Photic Stimulation Piperazines - pharmacology Rats Rats, Long-Evans Reaction Time - drug effects Reaction Time - physiology Reversal Learning - drug effects Serotonin Uptake Inhibitors - pharmacology Sucrose - administration & dosage Sweetening Agents - administration & dosage impulsivity serotonin hippocampus perseveration dopamine
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Summary:	Two experiments are reported in which rats with selective hippocampal lesions were tested on 2 prefrontal-dependent tasks. In Experiment 1, we compared the effects of lesions of the ventral hippocampus (vHC), dorsal hippocampus (dHC), and sham control surgery on the 5-choice reaction time task. Whereas rats with lesions of the dHC were indistinguishable from sham controls, those with vHC lesions showed increased premature responses and reduced accuracy throughout the experiment. The subsequent administration of systemic escitalopram (5 mg/kg), a selective serotonin reuptake inhibitor, reduced the number of premature responses in the vHC animals to control levels. In contrast, systemic injections of GBR 12909, a dopamine reuptake inhibitor, failed to ameliorate the impulsive deficit in the vHC group and, in addition, elevated perseverative responding in the vHC group only. In Experiment 2, we tested a separate group of rats with vHC lesions on a touchscreen visual discrimination and reversal learning task. Rats with vHC lesions acquired the visual discrimination as well as sham controls and showed normal inhibitory control of a previously reinforced response during reversal learning. These data support a role for the vHC in inhibitory control functions, especially in the inhibitory control of impulsive actions.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	1047-3211 1460-2199
DOI:	10.1093/cercor/bhs121