Search Results - "Hilgers, Ralf‐Dieter"

Intensive Supportive Care plus Immunosuppression in IgA Nephropathy by Rauen, Thomas, Eitner, Frank, Fitzner, Christina, Sommerer, Claudia, Zeier, Martin, Otte, Britta, Panzer, Ulf, Peters, Harm, Benck, Urs, Mertens, Peter R, Kuhlmann, Uwe, Witzke, Oliver, Gross, Oliver, Vielhauer, Volker, Mann, Johannes F.E, Hilgers, Ralf-Dieter, Floege, Jürgen

“…This open-label trial randomly assigned patients with IgA nephropathy to supportive care or supportive care plus immunosuppression. The added immunosuppression…”
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randomizeR : An R Package for the Assessment and Implementation of Randomization in Clinical Trials by Uschner, Diane, Schindler, David, Hilgers, Ralf-Dieter, Heussen, Nicole

“…Randomization in clinical trials is the key design technique to ensure the comparability of treatment groups. Although there exist a large number of software…”
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Innovative methodologies for rare diseases clinical trials by Nabbout, Rima, Hilgers, Ralf-Dieter

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Confidence interval comparison: Precision of maximum likelihood estimates in LLOQ affected data by Bülow, Tanja, Hilgers, Ralf-Dieter, Heussen, Nicole

“…When data is derived under a single or multiple lower limits of quantification (LLOQ), estimation of distribution parameters as well as precision of these…”
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Designing Clinical Trials in Wilson’s Disease by Ott, Peter, Ala, Aftab, Askari, Frederick K., Czlonkowska, Anna, Hilgers, Ralf‐Dieter, Poujois, Aurélia, Roberts, Eve A., Sandahl, Thomas Damgaard, Weiss, Karl Heinz, Ferenci, Peter, Schilsky, Michael L.

“…Background and Aims Wilson’s disease (WD) is an autosomal‐recessive disorder caused by ATP7B gene mutations leading to pathological accumulation of copper in…”
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Recommendations for the design of small population clinical trials by Day, Simon, Jonker, Anneliene Hechtelt, Lau, Lilian Pek Lian, Hilgers, Ralf-Dieter, Irony, Ilan, Larsson, Kristina, Roes, Kit Cb, Stallard, Nigel

“…Orphan drug development faces numerous challenges, including low disease prevalence, patient population heterogeneity, and strong presence of paediatric…”
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The impact of selection bias in randomized multi-arm parallel group clinical trials by Uschner, Diane, Hilgers, Ralf-Dieter, Heussen, Nicole

“…The impact of selection bias on the results of clinical trials has been analyzed extensively for trials of two treatments, yet its impact in multi-arm trials…”
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A roadmap to using randomization in clinical trials by Berger, Vance W, Bour, Louis Joseph, Carter, Kerstine, Chipman, Jonathan J, Everett, Colin C, Heussen, Nicole, Hewitt, Catherine, Hilgers, Ralf-Dieter, Luo, Yuqun Abigail, Renteria, Jone, Ryeznik, Yevgen, Sverdlov, Oleksandr, Uschner, Diane

“…Randomization is the foundation of any clinical trial involving treatment comparison. It helps mitigate selection bias, promotes similarity of treatment groups…”
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Observations below multiple lower limits of quantification: How to estimate the mean and variance by Berger, Tanja, Hilgers, Ralf‐Dieter, Heussen, Nicole

“…Multiple lower limits of quantification (MLOQs) result if various laboratories are involved in the analysis of concentration data and some observations are too…”
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Progression characteristics of the European Friedreich’s Ataxia Consortium for Translational Studies (EFACTS): a 2 year cohort study by Reetz, Kathrin, MD, Dogan, Imis, PhD, Hilgers, Ralf-Dieter, Prof, Giunti, Paola, MD, Mariotti, Caterina, MD, Durr, Alexandra, MD, Boesch, Sylvia, MD, Klopstock, Thomas, MD, de Rivera, Francisco Javier Rodriguez, MD, Schöls, Ludger, Prof, Klockgether, Thomas, Prof, Bürk, Katrin, MD, Rai, Myriam, PhD, Pandolfo, Massimo, Prof, Schulz, Jörg B, Prof

“…Summary Background The European Friedreich’s Ataxia Consortium for Translational Studies (EFACTS) is a prospective international registry investigating the…”
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Zinc supplementation induces regulatory T cells by inhibition of Sirt‐1 deacetylase in mixed lymphocyte cultures by Rosenkranz, Eva, Metz, Claudia H.D, Maywald, Martina, Hilgers, Ralf‐Dieter, Weßels, Inga, Senff, Tina, Haase, Hajo, Jäger, Maximilian, Ott, Melanie, Aspinall, Richard, Plümäkers, Birgit, Rink, Lothar

“…SCOPE: Zinc is an essential trace element, regulating immune function. Its deficiency results in immune dysfunction and transplant rejection. In here, a…”
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Differences in degradation behavior of two non-cross-linked collagen barrier membranes: an in vitro and in vivo study by Bozkurt, Ahmet, Apel, Christian, Sellhaus, Bernd, van Neerven, Sabien, Wessing, Bastian, Hilgers, Ralf-Dieter, Pallua, Norbert

“…Objectives Collagen barrier membranes are used in guided bone regeneration/guided tissue regeneration because of their excellent bio‐ and cytocompatibility…”
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ERDO - a framework to select an appropriate randomization procedure for clinical trials by Hilgers, Ralf-Dieter, Uschner, Diane, Rosenberger, William F, Heussen, Nicole

“…Randomization is considered to be a key feature to protect against bias in randomized clinical trials. Randomization induces comparability with respect to…”
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Assessing the impact of selection bias on test decisions in trials with a time‐to‐event outcome by Rückbeil, Marcia Viviane, Hilgers, Ralf‐Dieter, Heussen, Nicole

“…If past treatment assignments are unmasked, selection bias may arise even in randomized controlled trials. The impact of such bias can be measured by…”
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Responsiveness of the Scale for the Assessment and Rating of Ataxia and Natural History in 884 Recessive and Early Onset Ataxia Patients by Traschütz, Andreas, Adarmes‐Gómez, Astrid D., Anheim, Mathieu, Baets, Jonathan, Brais, Bernard, Gagnon, Cynthia, Gburek‐Augustat, Janina, Doss, Sarah, Hanağası, Haşmet A., Kamm, Christoph, Klivenyi, Peter, Klockgether, Thomas, Klopstock, Thomas, Minnerop, Martina, Münchau, Alexander, Renaud, Mathilde, Santorelli, Filippo M., Schöls, Ludger, Thieme, Andreas, Vielhaber, Stefan, Warrenburg, Bart P., Zanni, Ginevra, Hilgers, Ralf‐Dieter, Synofzik, Matthis

“…Objective The Scale for the Assessment and Rating of Ataxia (SARA) is the most widely applied clinical outcome assessment (COA) for genetic ataxias, but…”
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Composite endpoints, including patient reported outcomes, in rare diseases by Verbeeck, Johan, Dirani, Maya, Bauer, Johann W, Hilgers, Ralf-Dieter, Molenberghs, Geert, Nabbout, Rima

“…When assessing the efficacy of a treatment in any clinical trial, it is recommended by the International Conference on Harmonisation to select a single…”
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Randomization in survival studies: An evaluation method that takes into account selection and chronological bias by Rückbeil, Marcia Viviane, Hilgers, Ralf-Dieter, Heussen, Nicole

“…The random allocation of patients to treatments is a crucial step in the design and conduct of a randomized controlled trial. For this purpose, a variety of…”
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Istore: a project on innovative statistical methodologies to improve rare diseases clinical trials in limited populations by Schoenen, Stefanie, Verbeeck, Johan, Koletzko, Lukas, Brambilla, Isabella, Kuchenbuch, Mathieu, Dirani, Maya, Zimmermann, Georg, Dette, Holger, Hilgers, Ralf-Dieter, Molenberghs, Geert, Nabbout, Rima

“…The conduct of rare disease clinical trials is still hampered by methodological problems. The number of patients suffering from a rare condition is variable,…”
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Implant placement under existing removable dental prostheses and its effect on oral health-related quality of life by Wolfart, Stefan, Moll, Daniel, Hilgers, Ralf-Dieter, Wolfart, Mona, Kern, Matthias

“…Objective One aim of this prospective clinical study was to measure the effects of strategicimplant placement under removable partial dental prostheses (RPDPs)…”
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Laterally closed tunnel technique with and without adjunctive photobiomodulation therapy for the management of isolated gingival recession—a randomized controlled assessor-blinded clinical trial by Lavu, Vamsi, Gutknecht, Norbert, Vasudevan, Amrutha, S.K, Balaji, Hilgers, Ralf-Dieter, Franzen, Rene

“…The objective of this prospective randomized controlled single-center clinical trial was to prove the efficacy of adjunctive photobiomodulation in improving…”
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