Search Results - "Hilgers, Mark T"

Computational stabilization of T cell receptors allows pairing with antibodies to form bispecifics by Froning, Karen, Maguire, Jack, Sereno, Arlene, Huang, Flora, Chang, Shawn, Weichert, Kenneth, Frommelt, Anton J., Dong, Jessica, Wu, Xiufeng, Austin, Heather, Conner, Elaine M., Fitchett, Jonathan R., Heng, Aik Roy, Balasubramaniam, Deepa, Hilgers, Mark T., Kuhlman, Brian, Demarest, Stephen J.

“…Recombinant T cell receptors (TCRs) can be used to redirect naïve T cells to eliminate virally infected or cancerous cells; however, they are plagued by low…”
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Crystal structure of active CDK4-cyclin D and mechanistic basis for abemaciclib efficacy by Gharbi, Severine Isabelle, Pelletier, Laura A., Espada, Alfonso, Gutiérrez, Jesus, Sanfeliciano, Sonia Maria Gutiérrez, Rauch, Charles T., Ganado, Maria Patricia, Baquero, Carmen, Zapatero, Elisabet, Zhang, Aiping, Benach, Jordi, Russell, Anna-Maria, Cano, Leticia, Gomez, Sandra, Broughton, Howard, Pulliam, Nicholas, Perez, Carmen Maria, Torres, Raquel, Debets, Marjoke F., de Dios, Alfonso, Puig, Oscar, Hilgers, Mark T., Lallena, Maria Jose

“…Despite the biological and therapeutic relevance of CDK4/6 for the treatment of HR+, HER2- advanced breast cancer, the detailed mode of action of CDK4/6…”
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Author Correction: Crystal structure of active CDK4-cyclin D and mechanistic basis for abemaciclib efficacy by Gharbi, Severine Isabelle, Pelletier, Laura A., Espada, Alfonso, Gutiérrez, Jesus, Sanfeliciano, Sonia Maria Gutiérrez, Rauch, Charles T., Ganado, Maria Patricia, Baquero, Carmen, Zapatero, Elisabet, Zhang, Aiping, Benach, Jordi, Russell, Anna-Maria, Cano, Leticia, Gomez, Sandra, Broughton, Howard, Pulliam, Nicholas, Perez, Carmen Maria, Torres, Raquel, Debets, Marjoke F., de Dios, Alfonso, Puig, Oscar, Hilgers, Mark T., Lallena, Maria Jose

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Structures of the N-Terminal Modules Imply Large Domain Motions during Catalysis by Methionine Synthase by Evans, John C, Huddler, Donald P, Hilgers, Mark T, Romanchuk, Gail, Matthews, Rowena G, Ludwig, Martha L

“…B12-dependent methionine synthase (MetH) is a large modular enzyme that utilizes the cobalamin cofactor as a methyl donor or acceptor in three separate…”
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Crystal Structure of the Quorum-Sensing Protein LuxS Reveals a Catalytic Metal Site by Hilgers, Mark T., Ludwig, Martha L.

“…The ability of bacteria to regulate gene expression in response to changes in cell density is termed quorum sensing. This behavior involves the synthesis and…”
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Crystal Structures of Active Fully Assembled Substrate- and Product-Bound Complexes of UDP-N-Acetylmuramic Acid:l-Alanine Ligase (MurC) from Haemophilus influenzae by Mol, Clifford D, Brooun, Alexei, Dougan, Douglas R, Hilgers, Mark T, Tari, Leslie W, Wijnands, Robert A, Knuth, Mark W, McRee, Duncan E, Swanson, Ronald V

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Structure-Based Design of New Dihydrofolate Reductase Antibacterial Agents: 7‑(Benzimidazol-1-yl)-2,4-diaminoquinazolines by Lam, Thanh, Hilgers, Mark T, Cunningham, Mark L, Kwan, Bryan P, Nelson, Kirk J, Brown-Driver, Vickie, Ong, Voon, Trzoss, Michael, Hough, Grayson, Shaw, Karen Joy, Finn, John

“…A new series of dihydrofolate reductase (DHFR) inhibitors, the 7-(benzimidazol-1-yl)-2,4-diaminoquinazolines, were designed and optimized for antibacterial…”
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Comparison of the Essential Cellular Functions of the Two murA Genes of Bacillus anthracis by KEDAR, G. C, BROWN-DRIVER, Vickie, REYES, Daniel R, HILGERS, Mark T, STIDHAM, Mark A, SHAW, Karen Joy, FINN, John, HASELBECK, Robert J

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Evaluation of the metS and murB Loci for Antibiotic Discovery Using Targeted Antisense RNA Expression Analysis in Bacillus anthracis by KEDAR, G. C, BROWN-DRIVER, Vickie, REYES, Daniel R, HILGERS, Mark T, STIDHAM, Mark A, SHAW, Karen Joy, FINN, John, HASELBECK, Robert J

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Identification of Bacteria-Selective Threonyl-tRNA Synthetase Substrate Inhibitors by Structure-Based Design by Teng, Min, Hilgers, Mark T, Cunningham, Mark L, Borchardt, Allen, Locke, Jeffrey B, Abraham, Sunny, Haley, Gregory, Kwan, Bryan P, Hall, Courtney, Hough, Grayson W, Shaw, Karen J, Finn, John

“…A series of potent and bacteria-selective threonyl-tRNA synthetase (ThrRS) inhibitors have been identified using structure-based drug design. These compounds…”
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