Search Results - "Hilfiker, A."

Development and Characterization of a Porcine Mitral Valve Scaffold for Tissue Engineering by Granados, M., Morticelli, L., Andriopoulou, S., Kalozoumis, P., Pflaum, M., Iablonskii, P., Glasmacher, B., Harder, M., Hegermann, J., Wrede, C., Tudorache, I., Cebotari, S., Hilfiker, A., Haverich, A., Korossis, Sotirios

“…Decellularized scaffolds represent a promising alternative for mitral valve (MV) replacement. This work developed and characterized a protocol for the…”
Get full text

mof, a putative acetyl transferase gene related to the Tip60 and MOZ human genes and to the SAS genes of yeast, is required for dosage compensation in Drosophila by Hilfiker, A, Hilfiker-Kleiner, D, Pannuti, A, Lucchesi, J.C

“…Dosage compensation is a regulatory process that insures that males and females have equal amounts of X-chromosome gene products. In Drosophila, this is…”
Get full text

A Novel Method for the Generation of Bioartificial Vascular Grafts by Aper, T, Wilhelmi, M, Gebhardt, C, Hoeffler, K, Benecke, N, Hilfiker, A, Haverich, A

Get full text

A de Novo Enantioselective Total Synthesis of (−)-Laulimalide by Nelson, Scott G, Cheung, Wing S, Kassick, Andrew J, Hilfiker, Mark A

“…An enantioselective total synthesis of the naturally occurring anticancer agent (−)-laulimalide is described. The synthesis is characterized by extensive use…”
Get full text

Prolactin – A New Marker for ECMO-Related Mortality by Neumann, A, Hilfiker-Kleiner, D, Kühn, C, Fegbeutel, C, Hilfiker, A, Haverich, A, Bara, C

“…Purpose Mortality in adult patients requiring ECMO support is high. We aimed to identify biomarkers and potential pathophysiological mechanisms triggered by…”
Get full text

379: Improved Bloodcompatibility of a Poly-4-Methyl-1-Pentene Gas Exchange Membrane by Endothelialization by Wiegmann, B, Hess, C, Hilfiker, A, Haverich, A, Fischer, S

Get full text

TISSUE ENGINEERING OF THE ATRIOVENTRICULAR VALVE: DECELLULARIZED MATRIX IN OVINE MITRAL ALLOGRAFT MODEL by P. P. Iablonskii, S. Cebotari, I. Tudorache, A. Hilfiker, S. M. Yashin, A. Haverich

“…Aim. Development of the tissue engineered matrix for the atrioventricular valve graft in a large animal model. Materials and мethods. The study was performed…”
Get full text

GSK1562590, a slowly dissociating urotensin‐II receptor antagonist, exhibits prolonged pharmacodynamic activity ex vivo by Behm, DJ, Aiyar, NV, Olzinski, AR, McAtee, JJ, Hilfiker, MA, Dodson, JW, Dowdell, SE, Wang, GZ, Goodman, KB, Sehon, CA, Harpel, MR, Willette, RN, Neeb, MJ, Leach, CA, Douglas, SA

“…BACKGROUND AND PURPOSE Recently identified antagonists of the urotensin–II (U‐II) receptor (UT) are of limited utility for investigating the…”
Get full text

Ligand-Modified Catalysts for the McMurry Pinacol Reaction by Lipski, Timothy A, Hilfiker, Mark A, Nelson, Scott G

Get full text

Cardiac Tissue Engineering: “Reconstructing the Motor of Life” by Bär, A., Haverich, A., Hilfiker, A.

Get full text

Discovery of GSK2798745: A Clinical Candidate for Inhibition of Transient Receptor Potential Vanilloid 4 (TRPV4) by Brooks, Carl A, Barton, Linda S, Behm, David J, Eidam, Hilary S, Fox, Ryan M, Hammond, Marlys, Hoang, Tram H, Holt, Dennis A, Hilfiker, Mark A, Lawhorn, Brian G, Patterson, Jaclyn R, Stoy, Patrick, Roethke, Theresa J, Ye, Guosen, Zhao, Steve, Thorneloe, Kevin S, Goodman, Krista B, Cheung, Mui

“…GSK2798745, a clinical candidate, was identified as an inhibitor of the transient receptor potential vanilloid 4 (TRPV4) ion channel for the treatment of…”
Get full text

Reverse Hydroxamate Inhibitors of Bone Morphogenetic Protein 1 by Kallander, Lara S., Washburn, David, Hilfiker, Mark A., Eidam, Hilary Schenck, Lawhorn, Brian G., Prendergast, Joanne, Fox, Ryan, Dowdell, Sarah, Manns, Sharada, Hoang, Tram, Zhao, Steve, Ye, Guosen, Hammond, Marlys, Holt, Dennis A., Roethke, Theresa, Hong, Xuan, Reid, Robert A., Gampe, Robert, Zhang, Hong, Diaz, Elsie, Rendina, Alan R., Quinn, Amy M., Willette, Bob

“…Bone Morphogenetic Protein 1 (BMP1) inhibition is a potential method for treating fibrosis because BMP1, a member of the zinc metalloprotease family, is…”
Get full text

Enantioenriched Dihydropyrones from β-Lactone Templates by Zipp, G. Greg, Hilfiker, Mark A, Nelson, Scott G

“…Optically active 4-substituted 2-oxetanones provide conduits for preparing 2,3-dihydro-4H-pyrone heterocycles. Enantioenriched β-lactones are prepared by…”
Get full text

Small intestinal submucosa segments as matrix for tissue engineering: review by Andrée, Birgit, Bär, Antonia, Haverich, Axel, Hilfiker, Andres

“…Tissue engineering (TE) is an emerging interdisciplinary field aiming at the restoration or improvement of impaired tissue function. A combination of cells,…”
Get more information

The gene virilizer is required for female-specific splicing controlled by Sxl, the master gene for sexual development in Drosophila by Hilfiker, A, Amrein, H, Dübendorfer, A, Schneiter, R, Nöthiger, R

“…The gene virilizer (vir) is needed for dosage compensation and sex determination in females and for an unknown vital function in both sexes. In genetic…”
Get full text

Prefabrication of heart valves by Goecke, T, Tudorache, I, Hilfiker, A, Haverich, A, Cebotari, S

“…Commonly used heart valve prostheses have specific drawbacks and limitations. Optimization of conventional methods and techniques for heart valve replacement…”
Get full text

Animal models and animal-free innovations for cardiovascular research: current status and routes to be explored. Consensus document of the ESC Working Group on Myocardial Function and the ESC Working Group on Cellular Biology of the Heart by van der Velden, Jolanda, Asselbergs, Folkert W, Bakkers, Jeroen, Batkai, Sandor, Bertrand, Luc, Bezzina, Connie R, Bot, Ilze, Brundel, Bianca J J M, Carrier, Lucie, Chamuleau, Steven, Ciccarelli, Michele, Dawson, Dana, Davidson, Sean M, Dendorfer, Andreas, Duncker, Dirk J, Eschenhagen, Thomas, Fabritz, Larissa, Falcão-Pires, Ines, Ferdinandy, Péter, Giacca, Mauro, Girao, Henrique, Gollmann-Tepeköylü, Can, Gyongyosi, Mariann, Guzik, Tomasz J, Hamdani, Nazha, Heymans, Stephane, Hilfiker, Andres, Hilfiker-Kleiner, Denise, Hoekstra, Alfons G, Hulot, Jean-Sébastien, Kuster, Diederik W D, van Laake, Linda W, Lecour, Sandrine, Leiner, Tim, Linke, Wolfgang A, Lumens, Joost, Lutgens, Esther, Madonna, Rosalinda, Maegdefessel, Lars, Mayr, Manuel, van der Meer, Peter, Passier, Robert, Perbellini, Filippo, Perrino, Cinzia, Pesce, Maurizio, Priori, Silvia, Remme, Carol Ann, Rosenhahn, Bodo, Schotten, Ulrich, Schulz, Rainer, Sipido, Karin R, Sluijter, Joost P G, van Steenbeek, Frank, Steffens, Sabine, Terracciano, Cesare M, Tocchetti, Carlo Gabriele, Vlasman, Patricia, Yeung, Kak Khee, Zacchigna, Serena, Zwaagman, Dayenne, Thum, Thomas

“…Cardiovascular diseases represent a major cause of morbidity and mortality, necessitating research to improve diagnostics, and to discover and test novel…”
Get full text

virilizer regulates Sex-lethal in the germline of Drosophila melanogaster by C. SchuLtt, A. Hilfiker, R. Nothiger

“…In Drosophila, the gene Sex-lethal (Sxl) is required for female development. It controls sexual differentiation in the soma, dosage compensation and oogenesis…”
Get full text

Optimization of a Novel Series of TRPV4 Antagonists with In Vivo Activity in a Model of Pulmonary Edema by Hilfiker, Mark A, Hoang, Tram H, Cornil, Johan, Eidam, Hilary S, Matasic, Daniel S, Roethke, Theresa J, Klein, Michael, Thorneloe, Kevin S, Cheung, Mui

“…High-throughput screening and subsequent hit optimization identified 1-piperidinylbenzimidazoles, exemplified by compound 1, as TRPV4 inhibitors. Lead…”
Get full text

Discovery of Aminofurazan-azabenzimidazoles as Inhibitors of Rho-Kinase with High Kinase Selectivity and Antihypertensive Activity by Stavenger, Robert A, Cui, Haifeng, Dowdell, Sarah E, Franz, Robert G, Gaitanopoulos, Dimitri E, Goodman, Krista B, Hilfiker, Mark A, Ivy, Robert L, Leber, Jack D, Marino, Joseph P, Oh, Hye-Ja, Viet, Andrew Q, Xu, Weiwei, Ye, Guosen, Zhang, Daohua, Zhao, Yongdong, Jolivette, Larry J, Head, Martha S, Semus, Simon F, Elkins, Patricia A, Kirkpatrick, Robert B, Dul, Edward, Khandekar, Sanjay S, Yi, Tracey, Jung, David K, Wright, Lois L, Smith, Gary K, Behm, David J, Doe, Christopher P, Bentley, Ross, Chen, Zunxuan X, Hu, Erding, Lee, Dennis

“…The discovery, proposed binding mode, and optimization of a novel class of Rho-kinase inhibitors are presented. Appropriate substitution on the 6-position of…”
Get full text