Search Results - "Hiley, C."

EDHF: spreading the influence of the endothelium by Garland, Christopher J, Hiley, C Robin, Dora, Kim A

“…Our view of the endothelium was transformed around 30 years ago, from one of an inert barrier to that of a key endocrine organ central to cardiovascular…”
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In silico patent searching reveals a new cannabinoid receptor by Baker, David, Pryce, Gareth, Davies, Wayne L., Hiley, C. Robin

“…Increasing evidence suggests that some cannabinoids mediate their effects independently of the known cannabinoid CB 1 and CB 2 receptors. Two recently…”
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The GPR55 agonist lysophosphatidylinositol relaxes rat mesenteric resistance artery and induces Ca2+ release in rat mesenteric artery endothelial cells by AlSuleimani, Y M, Hiley, C R

“…Background and Purpose Lysophosphatidylinositol (LPI), a lipid signalling molecule, activates GPR55 and elevates intracellular Ca2+. Here, we examine the…”
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Endocannabinoids and the Heart by Hiley, C Robin

“…Endocannabinoids, such as anandamide and 2-arachidonoylglycerol, are synthesized from membrane phospholipids in the heart and other cardiovascular tissues…”
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The GPR55 agonist lysophosphatidylinositol relaxes rat mesenteric resistance artery and induces Ca(2+) release in rat mesenteric artery endothelial cells by AlSuleimani, Y M, Hiley, C R

“…Lysophosphatidylinositol (LPI), a lipid signalling molecule, activates GPR55 and elevates intracellular Ca(2+). Here, we examine the actions of LPI in the rat…”
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Endothelial Nitric Oxide Suppresses Action-Potential-Like Transient Spikes and Vasospasm in Small Resistance Arteries by Smith, Josh F., Lemmey, Hamish A.L., Borysova, Lyudmyla, Hiley, C. Robin, Dora, Kim A., Garland, Christopher J.

“…Endothelial dysfunction in small arteries is a ubiquitous, early feature of cardiovascular disease, including hypertension. Dysfunction reflects reduced…”
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Intratumoural evolutionary landscape of high-risk prostate cancer: the PROGENY study of genomic and immune parameters by Linch, M., Goh, G., Hiley, C., Shanmugabavan, Y., McGranahan, N., Rowan, A., Wong, Y.N.S., King, H., Furness, A., Freeman, A., Linares, J., Akarca, A., Herrero, J., Rosenthal, R., Harder, N., Schmidt, G., Wilson, G.A., Birkbak, N.J., Mitter, R., Dentro, S., Cathcart, P., Arya, M., Johnston, E., Scott, R., Hung, M., Emberton, M., Attard, G., Szallasi, Z., Punwani, S., Quezada, S.A., Marafioti, T., Gerlinger, M., Ahmed, H.U., Swanton, C.

“…Intratumoural heterogeneity (ITH) is well recognised in prostate cancer (PC), but its role in high-risk disease is uncertain. A prospective, single-arm,…”
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Reduced Fractionation in Lung Cancer Patients Treated with Curative-intent Radiotherapy during the COVID-19 Pandemic by Faivre-Finn, C., Fenwick, J.D., Franks, K.N., Harrow, S., Hatton, M.Q.F., Hiley, C., McAleese, J.J., McDonald, F., O'Hare, J., Peedell, C., Pope, T., Powell, C., Rulach, R., Toy, E.

“…Patients treated with curative-intent lung radiotherapy are in the group at highest risk of severe complications and death from COVID-19. There is therefore an…”
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Mechanisms of vasorelaxation induced by oleoylethanolamide in the rat small mesenteric artery by AlSuleimani, Yousuf M, Hiley, C Robin

“…The actions of the anandamide-like mono-unsaturated fatty acid oleoylethanolamide (OEA) were first linked to satiety and control of food intake and recently…”
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mitochondria-targeted S-nitrosothiol modulates respiration, nitrosates thiols, and protects against ischemia-reperfusion injury by Prime, Tracy A, Blaikie, Frances H, Evans, Cameron, Nadtochiy, Sergiy M, James, Andrew M, Dahm, Christina C, Vitturi, Dario A, Patel, Rakesh P, Hiley, C. Robin, Abakumova, Irina, Requejo, Raquel, Chouchani, Edward T, Hurd, Thomas R, Garvey, John F, Taylor, Cormac T, Brookes, Paul S, Smith, Robin A.J, Murphy, Michael P

“…Nitric oxide (NO{bullet}) competitively inhibits oxygen consumption by mitochondria at cytochrome c oxidase and S-nitrosates thiol proteins. We developed…”
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Human urotensin‐II is an endothelium‐dependent vasodilator in rat small arteries by Bottrill, Fiona E, Douglas, Stephen A, Hiley, C Robin, White, Richard

“…The possible role of the endothelium in modulating responses to human urotensin‐II (U‐II) was investigated using isolated segments of rat thoracic aorta, small…”
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Lister strain vaccinia virus, a potential therapeutic vector targeting hypoxic tumours by Hiley, C T, Yuan, M, Lemoine, N R, Wang, Y

“…Hypoxia contributes to the aggressive and treatment-resistant phenotype of pancreatic ductal adenocarcinoma. Oncolytic vaccinia virus has potential as an…”
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Redox-controlled potassium intercalation into two polyaromatic hydrocarbon solids by Romero, F. Denis, Pitcher, M. J., Hiley, C. I., Whitehead, G. F. S., Kar, S., Ganin, A. Y., Antypov, D., Collins, C., Dyer, M. S., Klupp, G., Colman, R. H., Prassides, K., Rosseinsky, M. J.

“…Alkali metal intercalation into polyaromatic hydrocarbons (PAHs) has been studied intensely after reports of superconductivity in a number of potassium- and…”
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Neutrophil–Lymphocyte Ratio and Absolute Lymphocyte Count as Prognostic Markers in Patients Treated with Curative-intent Radiotherapy for Non-small Cell Lung Cancer by Punjabi, A., Barrett, E., Cheng, A., Mulla, A., Walls, G., Johnston, D., McAleese, J., Moore, K., Hicks, J., Blyth, K., Denholm, M., Magee, L., Gilligan, D., Silverman, S., Qureshi, M., Clinch, H., Hatton, M., Philipps, L., Brown, S., O'Brien, M., McDonald, F., Faivre-Finn, C., Hiley, C., Evison, M.

“…The neutrophil–lymphocyte ratio (NLR) and the absolute lymphocyte count (ALC) have been proposed as prognostic markers in non-small cell lung cancer (NSCLC)…”
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Impact of the COVID-19 Pandemic on Outcomes for Patients with Lung Cancer Receiving Curative-intent Radiotherapy in the UK by Fornacon-Wood, I., Banfill, K., Ahmad, S., Britten, A., Carson, C., Dorey, N., Hatton, M., Hiley, C., Thippu Jayaprakash, K., Jegannathen, A., Kidd, A.C., Koh, P., Panakis, N., Peedell, C., Peters, A., Pope, A., Powell, C., Stilwell, C., Thomas, B., Toy, E., Wicks, K., Wood, V., Yahya, S., Price, G., Faivre-Finn, C.

“…Previous work found that during the first wave of the COVID-19 pandemic, 34% of patients with lung cancer treated with curative-intent radiotherapy in the UK…”
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Changes in the Management of Patients having Radical Radiotherapy for Lung Cancer during the First Wave of the COVID-19 Pandemic in the UK by Banfill, K., Croxford, W., Fornacon-Wood, I., Wicks, K., Ahmad, S., Britten, A., Carson, C., Dorey, N., Hatton, M., Hiley, C., Thippu Jayaprakash, K., Jegannathen, A., Koh, P., Panakis, N., Peedell, C., Pope, A., Powell, C., Stilwell, C., Thomas, B., Toy, E., Wood, V., Yahya, S., Zhou, S.Y., Price, G., Faivre-Finn, C.

“…In response to the COVID-19 pandemic, guidelines on reduced fractionation for patients treated with curative-intent radiotherapy were published, aimed at…”
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Predicting the Risk of Disease Recurrence and Death Following Curative-intent Radiotherapy for Non-small Cell Lung Cancer: The Development and Validation of Two Scoring Systems From a Large Multicentre UK Cohort by Evison, M., Barrett, E., Cheng, A., Mulla, A., Walls, G., Johnston, D., McAleese, J., Moore, K., Hicks, J., Blyth, K., Denholm, M., Magee, L., Gilligan, D., Silverman, S., Hiley, C., Qureshi, M., Clinch, H., Hatton, M., Philipps, L., Brown, S., O'Brien, M., McDonald, F., Faivre-Finn, C.

“…There is a paucity of evidence on which to produce recommendations on neither the clinical nor the imaging follow-up of lung cancer patients after…”
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Mechanisms of vasorelaxation induced by the cannabidiol analogue compound O-1602 in the rat small mesenteric artery by Al Suleimani, Y.M., Al Mahruqi, A.S., Hiley, C.R.

“…Atypical cannabinoid O-1602 (5-Methyl-4-[(1R,6R)-3-methyl-6-(1-cyclohexen-1-yl]-1,3-benzenediol) induces vasorelaxation and activates the orphan G…”
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Characterization of calcium signals provoked by lysophosphatidylinositol in human microvascular endothelial cells by Al Suleimani, Y M, Hiley, C R

“…The lipid molecule, lysophosphatidylinositol (LPI), is hypothesised to form part of a novel lipid signalling system that involves the G protein-coupled…”
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A comparison of EDHF‐mediated and anandamide‐induced relaxations in the rat isolated mesenteric artery by White, Richard, Hiley, C. Robin

“…1 Relaxation of the methoxamine‐precontracted rat small mesenteric artery by endothelium‐derived hyperpolarizing factor (EDHF) was compared with relaxation to…”
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