Search Results - "Hilderink, Angelika"

Ca2+-activated sphingomyelin scrambling and turnover mediate ESCRT-independent lysosomal repair by Niekamp, Patrick, Scharte, Felix, Sokoya, Tolulope, Vittadello, Laura, Kim, Yeongho, Deng, Yongqiang, Südhoff, Elisabeth, Hilderink, Angelika, Imlau, Mirco, Clarke, Christopher J., Hensel, Michael, Burd, Christopher G., Holthuis, Joost C. M.

“…Lysosomes are vital organelles vulnerable to injuries from diverse materials. Failure to repair or sequester damaged lysosomes poses a threat to cell…”
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A search for ceramide binding proteins using bifunctional lipid analogs yields CERT-related protein StarD7 by Bockelmann, Svenja, Mina, JohnG.M., Korneev, Sergei, Hassan, Dina G., Müller, Dagmar, Hilderink, Angelika, Vlieg, Hedwich C., Raijmakers, Reinout, Heck, AlbertJ.R., Haberkant, Per, Holthuis, JoostC.M.

“…Ceramides are central intermediates of sphingolipid metabolism with dual roles as mediators of cellular stress signaling and mitochondrial apoptosis. How…”
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Pathogenic variants of sphingomyelin synthase SMS2 disrupt lipid landscapes in the secretory pathway by Sokoya, Tolulope, Parolek, Jan, Foged, Mads Møller, Danylchuk, Dmytro I, Bozan, Manuel, Sarkar, Bingshati, Hilderink, Angelika, Philippi, Michael, Botto, Lorenzo D, Terhal, Paulien A, Mäkitie, Outi, Piehler, Jacob, Kim, Yeongho, Burd, Christopher G, Klymchenko, Andrey S, Maeda, Kenji, Holthuis, Joost C M

“…Sphingomyelin is a dominant sphingolipid in mammalian cells. Its production in the Golgi traps cholesterol synthesized in the ER to promote formation of a…”
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Switching head group selectivity in mammalian sphingolipid biosynthesis by active-site-engineering of sphingomyelin synthases by Kol, Matthijs, Panatala, Radhakrishnan, Nordmann, Mirjana, Swart, Leoni, van Suijlekom, Leonie, Cabukusta, Birol, Hilderink, Angelika, Grabietz, Tanja, Mina, John G.M., Somerharju, Pentti, Korneev, Sergei, Tafesse, Fikadu G., Holthuis, Joost C.M.

“…SM is a fundamental component of mammalian cell membranes that contributes to mechanical stability, signaling, and sorting. Its production involves the…”
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Sphingomyelin synthase-related protein SMSr is a suppressor of ceramide-induced mitochondrial apoptosis by Tafesse, Fikadu G, Vacaru, Ana M, Bosma, Elleke F, Hermansson, Martin, Jain, Amrita, Hilderink, Angelika, Somerharju, Pentti, Holthuis, Joost C M

“…Cells synthesize ceramides in the endoplasmic reticulum (ER) as precursors for sphingolipids to form an impermeable plasma membrane. As ceramides are engaged…”
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ER residency of the ceramide phosphoethanolamine synthase SMSr relies on homotypic oligomerization mediated by its SAM domain by Cabukusta, Birol, Kol, Matthijs, Kneller, Laura, Hilderink, Angelika, Bickert, Andreas, Mina, John G. M., Korneev, Sergei, Holthuis, Joost C. M.

“…SMSr/SAMD8 is an ER-resident ceramide phosphoethanolamine synthase with a critical role in controlling ER ceramides and suppressing ceramide-induced apoptosis…”
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Switching head group selectivity in mammalian sphingolipid biosynthesis by active-site engineering of sphingomyelin synthases by Kol, Matthijs, Panatala, Radhakrishnan, Nordmann, Mirjana, Swart, Leoni, van Suijlekom, Leonie, Cabukusta, Birol, Hilderink, Angelika, Grabietz, Tanja, Mina, John G.M., Somerharju, Pentti, Korneev, Sergei, Tafesse, Fikadu G., Holthuis, Joost C.M.

“…SM is a fundamental component of mammalian cell membranes that contributes to mechanical stability, signaling, and sorting. Its production involves the…”
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Ceramide phosphoethanolamine synthase SMSr is a target of caspase-6 during apoptotic cell death by Cabukusta, Birol, Nettebrock, Niclas T, Kol, Matthijs, Hilderink, Angelika, Tafesse, Fikadu G, Holthuis, Joost C M

“…Ceramides are essential precursors of sphingolipids with a dual role as mediators of apoptotic cell death. Previous work revealed that the ER-resident ceramide…”
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Ca 2+ -activated sphingomyelin scrambling and turnover mediate ESCRT-independent lysosomal repair by Niekamp, Patrick, Scharte, Felix, Sokoya, Tolulope, Vittadello, Laura, Kim, Yeongho, Deng, Yongqiang, Südhoff, Elisabeth, Hilderink, Angelika, Imlau, Mirco, Clarke, Christopher J, Hensel, Michael, Burd, Christopher G, Holthuis, Joost C M

“…Lysosomes are vital organelles vulnerable to injuries from diverse materials. Failure to repair or sequester damaged lysosomes poses a threat to cell…”
Get full text