Search Results - "Hildeman, D"

Mcl-1 antagonizes Bax/Bak to promote effector CD4+ and CD8+ T-cell responses by Tripathi, P, Koss, B, Opferman, J T, Hildeman, D A

“…Members of the Bcl-2 family have critical roles in regulating tissue homeostasis by modulating apoptosis. Anti-apoptotic molecules physically interact and…”
Get full text

Apoptosis and the homeostatic control of immune responses by Hildeman, David, Jorgensen, Trine, Kappler, John, Marrack, Philippa

“…Normal homeostasis of the immune system is controlled by a balance of production and death. During an immune response, homeostasis is disturbed as…”
Get full text

Impact of conditional deletion of the pro-apoptotic BCL-2 family member BIM in mice by Herold, M J, Stuchbery, R, Mérino, D, Willson, T, Strasser, A, Hildeman, D, Bouillet, P

“…The pro-apoptotic BH3-only BCL-2 family member BIM is a critical determinant of hematopoietic cell development and homeostasis. It has been argued that the…”
Get full text

Bim controls IL-15 availability and limits engagement of multiple BH3-only proteins by Kurtulus, S, Sholl, A, Toe, J, Tripathi, P, Raynor, J, Li, K-P, Pellegrini, M, Hildeman, D A

“…During the effector CD8+ T-cell response, transcriptional differentiation programs are engaged that promote effector T cells with varying memory potential…”
Get full text

Sensitization of T cells to apoptosis--a role for ROS? by Tripathi, P, Hildeman, D

“…T cell homeostasis is achieved by balancing the production and proliferation of T cells with their apoptotic cell death. Activation of naïve T cells by antigen…”
Get full text

T cells compete for access to antigen-bearing antigen-presenting cells by Kedl, R M, Rees, W A, Hildeman, D A, Schaefer, B, Mitchell, T, Kappler, J, Marrack, P

“…These studies tested whether antigenic competition between T cells occurs. We generated CD8(+) T cell responses in H-2(b) mice against the dominant ovalbumin…”
Get full text

Reactive Oxygen Species Regulate Activation-Induced T Cell Apoptosis by Hildeman, David A, Mitchell, Tom, Teague, T.Kent, Henson, Peter, Day, Brian J, Kappler, John, Marrack, Philippa C

“…Reactive oxygen species (ROS) mediate apoptosis in a number of cell types. We studied the role that ROS play in activated T cell apoptosis by activating T…”
Get full text

(601) - Decoding T Cell Clonal Dynamics in Acute Lung Rejection by Potter, A., Wikenheiser-Brokamp, K., Hildeman, D., Sharma, N., Gu, M., Patel, K., Qureshi, M., Khan, M.M., Wallace, C., Ziady, A., Hayes, D.

Get full text

An animal model of hemophagocytic lymphohistiocytosis (HLH): CD8+ T cells and interferon gamma are essential for the disorder by Jordan, Michael B., Hildeman, David, Kappler, John, Marrack, Philippa

“…Hemophagocytic lymphohistiocytosis (HLH) is a rare disorder with familial and acquired forms. The familial form is associated with mutations in the perforin…”
Get full text

Vaccination against persistent viral infection exacerbates CD4+ T-cell-mediated immunopathological disease by Hildeman, D, Yañez, D, Pederson, K, Havighurst, T, Muller, D

“…Article Usage Stats Services JVI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
Get full text

C5a Negatively Regulates Toll-like Receptor 4-Induced Immune Responses by Hawlisch, Heiko, Belkaid, Yasmine, Baelder, Ralf, Hildeman, David, Gerard, Craig, Köhl, Jörg

“…The complement system and the Toll-like receptors (TLRs) are two central arms of innate immunity that are critical to host defense as well as the development…”
Get full text

Mcl-1 antagonizes Bax/Bak to promote effector CD4 super(+) and CD8 super(+) T-cell responses by Tripathi, P, Koss, B, Opferman, J T, Hildeman, D A

“…Members of the Bcl-2 family have critical roles in regulating tissue homeostasis by modulating apoptosis. Anti-apoptotic molecules physically interact and…”
Get full text

Homeostasis of alpha beta TCR+ T cells by Marrack, P, Bender, J, Hildeman, D, Jordan, M, Mitchell, T, Murakami, M, Sakamoto, A, Schaefer, B C, Swanson, B, Kappler, J

“…Cytokines contribute to T cell homeostasis at all stages of T cell existence. However, the particular cytokine involved varies as T cells progress from a naïve…”
Get full text

Immunological adjuvants promote activated T cell survival via induction of Bcl-3 by Marrack, Philippa, Mitchell, Thomas C, Hildeman, David, Kedl, Ross M, Teague, T. Kent, Schaefer, Brian C, White, Janice, Zhu, Yanan, Kappler, John

“…Injection of soluble protein antigen into animals causes abortive proliferation of the responding T cells. Immunological adjuvants boost T cell responses at…”
Get full text

Antiapoptotic Mcl-1 is Critical for the Survival and Niche-Filling Capacity of Foxp3+ Regulatory T Cells by Pierson, W, Cauwe, B, Policheni, A, Schlenner, S M, Franckaert, D, Berges, J, Humblet-Baron, S, Schonefeldt, S, Herold, M J, Hildeman, D, Strasser, A, Bouillet, P, Lu, L-F, Matthys, P, Freitas, A A, Luther, R J, Weaver, C T, Dooley, J, Gray, D HD, Liston, A

“…FoxP3+ regulatory T cells (Treg) play a critical role in maintaining immune homeostasis. Harnessing the specific suppressive capabilities of Treg may be key to…”
Get full text

Activation Changes the Spectrum but Not the Diversity of Genes Expressed by T Cells by Teague, T. Kent, Hildeman, David, Kedl, Ross M., Mitchell, Tom, Rees, William, Schaefer, Brian C., Bender, Jeremy, Kappler, John, Marrack, Philippa

“…During activation T cells are thought to change their patterns of gene expression dramatically. To find out whether this is true for T cells activated in…”
Get full text

Increased yield of plasmid DNA during removal of CsCl by ethanol precipitation by Hildeman, D A, Muller, D

Get full text

Activation-induced inhibition of interleukin 6-mediated T cell survival and signal transducer and activator of transcription 1 signaling by Teague, T K, Schaefer, B C, Hildeman, D, Bender, J, Mitchell, T, Kappler, J W, Marrack, P

“…The cytokines interleukin (IL)-2, IL-4, IL-6, IL-7, and IL-15 have all previously been shown to inhibit resting T cell death in vitro. We have found a…”
Get full text

Regulation of T-cell apoptosis by reactive oxygen species by Hildeman, David A.

“…To ensure that a constant number of T cells are preserved in the peripheral lymphoid organs, the production and proliferation of T cells must be balanced out…”
Get full text

T-cell survival by Marrack, Philippa, Mitchell, Tom, Bender, Jeremy, Hildeman, David, Kedl, Ross, Teague, Kent, Kappler, John

“…Like other cells, T cells are dependent on signals from their environment for their survival. Resting T cells are supported in vitro by cytokines such as…”
Get full text