Search Results - "Hildahl, Jon"
-
1
Zebrafish as a model system for characterization of nanoparticles against cancer
Published in Nanoscale (14-01-2016)“…Therapeutic nanoparticles (NPs) have great potential to deliver drugs against human diseases. Encapsulation of drugs in NPs protects them from being…”
Get more information
Journal Article -
2
Embryonic development of gonadotrope cells and gonadotropic hormones – Lessons from model fish
Published in Molecular and cellular endocrinology (25-03-2014)“…•Gonadotropin genes are expressed during early development.•Recent advances using zebrafish and medaka enables in vivo monitoring of gonadotrope…”
Get full text
Journal Article -
3
Identified lhb-expressing cells from medaka (Oryzias latipes) show similar Ca(2+)-response to all endogenous Gnrh forms, and reveal expression of a novel fourth Gnrh receptor
Published in General and comparative endocrinology (01-04-2016)“…We have previously characterized the response to gonadotropin-releasing hormone (Gnrh) 2 in luteinizing hormone (lhb)-expressing cells from green fluorescent…”
Get full text
Journal Article -
4
Translocation of nanoparticles and Mycobacterium marinum across the intestinal epithelium in zebrafish and the role of the mucosal immune system
Published in Developmental and comparative immunology (01-02-2017)“…Nano- and microparticles are promising carrier systems for oral delivery of drugs or vaccines, particularly in fish aquaculture. However, the mechanisms of…”
Get full text
Journal Article -
5
Involvement of growth hormone-insulin-like growth factor I system in cranial remodeling during halibut metamorphosis as indicated by tissue- and stage-specific receptor gene expression and the presence of growth hormone receptor protein
Published in Cell and tissue research (01-05-2008)“…The role of growth hormone (GH) and insulin-like growth factor-I (IGF-I) in the tissue remodeling associated with the transition of a symmetrical larva to an…”
Get full text
Journal Article -
6
Growth Hormone Endocrinology of Salmonids: Regulatory Mechanisms and Mode of Action
Published in Fish physiology and biochemistry (01-01-2002)“…The focus of this review is on the regulatory mechanisms and the mode of action of GH in salmonids. To stimulate further research, it aims at highlighting…”
Get full text
Journal Article -
7
Identified lhb -expressing cells from medaka ( Oryzias latipes ) show similar Ca2+ -response to all endogenous Gnrh forms, and reveal expression of a novel fourth Gnrh receptor
Published in General and comparative endocrinology (01-04-2016)“…Highlights • Ca2+ imaging revealed three distinct response patterns to Gnrh1 and Gnrh3. • There were few significant differences in the response between Gnrh1,…”
Get full text
Journal Article -
8
Nanoparticles as Drug Delivery System against Tuberculosis in Zebrafish Embryos: Direct Visualization and Treatment
Published in ACS nano (22-07-2014)“…Nanoparticles (NPs) enclosing antibiotics have provided promising therapy against Mycobacterium tuberculosis (Mtb) in different mammalian models. However, the…”
Get full text
Journal Article -
9
Thioridazine in PLGA nanoparticles reduces toxicity and improves rifampicin therapy against mycobacterial infection in zebrafish
Published in Nanotoxicology (02-07-2016)“…Encapsulating antibiotics such as rifampicin in biodegradable nanoparticles provides several advantages compared to free drug administration, including reduced…”
Get full text
Journal Article -
10
A critical evaluation of Amicon Ultra centrifugal filters for separating proteins, drugs and nanoparticles in biosamples
Published in Journal of pharmaceutical and biomedical analysis (20-02-2016)“…[Display omitted] •Amicon centrifugation filters suited for isolating small molecules from proteins.•Validated LC–MS method for rifampicin and thioridazine in…”
Get full text
Journal Article -
11
The Molecular and Endocrine Basis of Flatfish Metamorphosis
Published in Reviews in fisheries science (01-01-2008)“…A significant component of aquaculture is the production of good quality larvae, and, in the case of flatfish, this is tied up with the change from a symmetric…”
Get full text
Journal Article -
12
Developmental tracing of luteinizing hormone β-subunit gene expression using green fluorescent protein transgenic medaka (Oryzias latipes) reveals a putative novel developmental function
Published in Developmental dynamics (01-11-2012)“…Background: Luteinizing hormone (LH) and follicle stimulating hormone (FSH), produced in gonadotrope cells in the adenohypophysis are key regulators of…”
Get full text
Journal Article -
13
Molecular characterization of three GnRH receptor paralogs in the European eel, Anguilla anguilla: Tissue-distribution and changes in transcript abundance during artificially induced sexual development
Published in Molecular and cellular endocrinology (30-04-2013)“…► Three GnRH receptor cDNAs were identified in European eel. ► Phylogenetic analysis revealed two Type I and one Type II GnRH-Rs in European eel. ► All three…”
Get full text
Journal Article -
14
Differential regulation of GnRH ligand and receptor genes in the brain and pituitary of Atlantic cod exposed to different photoperiod
Published in General and comparative endocrinology (01-01-2013)“…Highlights ► Pituitary GnRH-R2a gene expression increases in late-vitellogenic and running cod, whereas GnRH-R1b does not. ► Brain GnRH3 gene expression is…”
Get full text
Journal Article -
15
Identification and gene expression analysis of three GnRH genes in female Atlantic cod during puberty provides insight into GnRH variant gene loss in fish
Published in General and comparative endocrinology (01-07-2011)“…Highlights ► We have identified three pre-pro-gonadotropin releasing hormone (GnRH) genes in female Atlantic cod ( Gadus morhua ). ► One variant, gmGnRH1,…”
Get full text
Journal Article -
16
Four gonadotropin releasing hormone receptor genes in Atlantic cod are differentially expressed in the brain and pituitary during puberty
Published in General and comparative endocrinology (01-09-2011)“…Highlights ► Four GnRH receptors were identified in Atlantic cod. ► Phylogenetic analysis reveals 1 Type I and 3 Type II GnRH-Rs in Atlantic cod. ► All four…”
Get full text
Journal Article -
17
Developmental tracing of luteinizing hormone [beta]-subunit gene expression using green fluorescent protein transgenic medaka (Oryzias latipes) reveals a putative novel developmental function
Published in Developmental dynamics (01-11-2012)“…Background: Luteinizing hormone (LH) and follicle stimulating hormone (FSH), produced in gonadotrope cells in the adenohypophysis are key regulators of…”
Get full text
Journal Article -
18
Identification of two isoforms of Atlantic halibut insulin-like growth factor-I receptor genes and quantitative gene expression during metamorphosis
Published in Comparative Biochemistry and Physiology Part B: Biochemistry and Molecular Biology (01-07-2007)“…Insulin-like growth factor-I (IGF-I) is an important regulator of growth and development in vertebrates. Both the endocrine and paracrine actions of IGF-I are…”
Get full text
Journal Article -
19
Cloning of Atlantic halibut growth hormone receptor genes and quantitative gene expression during metamorphosis
Published in General and comparative endocrinology (01-04-2007)“…Abstract To gain insight into the possible regulatory role of the growth hormone (GH)-insulin-like growth factor I (IGF-I) system in flatfish metamorphosis,…”
Get full text
Journal Article -
20
Isolation of Atlantic halibut pituitary hormones by continuous-elution electrophoresis followed by fingerprint identification, and assessment of growth hormone content during larval development
Published in General and comparative endocrinology (15-01-2007)“…Abstract Continuous-elution electrophoresis (CEE) has been applied to separate putative hormones from adult Atlantic halibut pituitaries. Soluble proteins were…”
Get full text
Journal Article