Search Results - "Hilbers, Peter"

Pathway complexity in supramolecular polymerization by Korevaar, Peter A., George, Subi J., Markvoort, Albert J., Smulders, Maarten M. J., Hilbers, Peter A. J., Schenning, Albert P. H. J., De Greef, Tom F. A., Meijer, E. W.

“…Kinetic control of the self-assembly of the π-conjugated oligomer S -chiral oligo( p -phenylenevinylene) (SOPV) reveals two competing pathways, leading to a…”
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The role of collagen in bone apatite formation in the presence of hydroxyapatite nucleation inhibitors by Sommerdijk, Nico A. J. M, Nudelman, Fabio, Pieterse, Koen, George, Anne, Bomans, Paul H. H, Friedrich, Heiner, Brylka, Laura J, Hilbers, Peter A. J, de With, Gijsbertus

“…Bone is a composite material in which collagen fibrils form a scaffold for a highly organized arrangement of uniaxially oriented apatite crystals. In the…”
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Programmable chemical reaction networks: emulating regulatory functions in living cells using a bottom-up approach by van Roekel, Hendrik W H, Rosier, Bas J H M, Meijer, Lenny H H, Hilbers, Peter A J, Markvoort, Albert J, Huck, Wilhelm T S, de Greef, Tom F A

“…Living cells are able to produce a wide variety of biological responses when subjected to biochemical stimuli. It has become apparent that these biological…”
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An Equilibrium Model for Chiral Amplification in Supramolecular Polymers by ten Eikelder, Huub M. M, Markvoort, Albert J, de Greef, Tom F. A, Hilbers, Peter A. J

“…We describe a model that rationalizes amplification of chirality in cooperative supramolecular copolymerization. The model extends nucleation-elongation based…”
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Counterion-Dependent Mechanisms of DNA Origami Nanostructure Stabilization Revealed by Atomistic Molecular Simulation by Roodhuizen, Job A. L, Hendrikx, Philip J. T. M, Hilbers, Peter A. J, de Greef, Tom F. A, Markvoort, Albert J

“…The DNA origami technique has proven to have tremendous potential for therapeutic and diagnostic applications like drug delivery, but the relatively low…”
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Theoretical models of nonlinear effects in two-component cooperative supramolecular copolymerizations by Markvoort, Albert J., ten Eikelder, Huub M.M., Hilbers, Peter A.J., de Greef, Tom F.A., Meijer, E.W.

“…The understanding of multi-component mixtures of self-assembling molecules under thermodynamic equilibrium can only be advanced by a combined experimental and…”
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Multivalency in a Dendritic Host–Guest System by Smeijers, A. F, Pieterse, Koen, Hilbers, Peter A. J, Markvoort, Albert J

“…Multivalency is an important instrument in the supramolecular chemistry toolkit for the creation of strong specific interactions. In this paper we investigate…”
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genome‐scale metabolic network reconstruction of tomato (Solanum lycopersicum L.) and its application to photorespiratory metabolism by Yuan, Huili, Cheung, C.Y. Maurice, Poolman, Mark G, Hilbers, Peter A. J, Riel, Natal A. W

“…Tomato (Solanum lycopersicum L.) has been studied extensively due to its high economic value in the market, and high content in health‐promoting antioxidant…”
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Interpretable systems biomarkers predict response to immune-checkpoint inhibitors by Lapuente-Santana, Óscar, van Genderen, Maisa, Hilbers, Peter A.J., Finotello, Francesca, Eduati, Federica

“…Cancer cells can leverage several cell-intrinsic and -extrinsic mechanisms to escape immune system recognition. The inherent complexity of the tumor…”
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On the role of membrane embedding, protein rigidity and transmembrane length in lipid membrane fusion by van Tilburg, Marco, Hilbers, Peter A J, Markvoort, Albert J

“…The fusion of biological membranes is ubiquitous in natural processes like exo- and endocytosis, intracellular trafficking and viral entry. Membrane fusion is…”
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A unified theory for osteonal and hemi-osteonal remodeling by van Oers, René F.M, Ruimerman, Ronald, Tanck, Esther, Hilbers, Peter A.J, Huiskes, Rik

“…Abstract The process of bone remodeling is carried out by ‘basic multicellular units’ of osteoclasts and osteoblasts. Osteoclasts excavate a resorption space…”
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In vivo and in silico dynamics of the development of Metabolic Syndrome by Rozendaal, Yvonne J W, Wang, Yanan, Paalvast, Yared, Tambyrajah, Lauren L, Li, Zhuang, Willems van Dijk, Ko, Rensen, Patrick C N, Kuivenhoven, Jan A, Groen, Albert K, Hilbers, Peter A J, van Riel, Natal A W

“…The Metabolic Syndrome (MetS) is a complex, multifactorial disorder that develops slowly over time presenting itself with large differences among MetS…”
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Kinetics of the Fischer-Tropsch Reaction by Markvoort, Albert J., van Santen, Rutger A., Hilbers, Peter A. J., Hensen, Emiel J. M.

“…Long carbon chains: Self‐assembly of monomeric carbon intermediates into long‐chain hydrocarbons on catalytically reactive surface (see picture) was studied…”
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Characterization of disease-specific cellular abundance profiles of chronic inflammatory skin conditions from deconvolution of biopsy samples by Félix Garza, Zandra C, Lenz, Michael, Liebmann, Joerg, Ertaylan, Gökhan, Born, Matthias, Arts, Ilja C W, Hilbers, Peter A J, van Riel, Natal A W

“…Psoriasis and atopic dermatitis are two inflammatory skin diseases with a high prevalence and a significant burden on the patients. Underlying molecular…”
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Relating osteon diameter to strain by van Oers, René F.M, Ruimerman, Ronald, van Rietbergen, Bert, Hilbers, Peter A.J, Huiskes, Rik

“…Abstract Osteon diameter is generally smaller in bone regions that experience larger strains. A mechanism relating osteon diameter to strain is as yet unknown…”
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Proteomic analysis in type 2 diabetes patients before and after a very low calorie diet reveals potential disease state and intervention specific biomarkers by Sleddering, Maria A, Markvoort, Albert J, Dharuri, Harish K, Jeyakar, Skhandhan, Snel, Marieke, Juhasz, Peter, Lynch, Moira, Hines, Wade, Li, Xiaohong, Jazet, Ingrid M, Adourian, Aram, Hilbers, Peter A J, Smit, Johannes W A, Van Dijk, Ko Willems

“…Very low calorie diets (VLCD) with and without exercise programs lead to major metabolic improvements in obese type 2 diabetes patients. The mechanisms…”
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Optimal experiment design for model selection in biochemical networks by Vanlier, Joep, Tiemann, Christian A, Hilbers, Peter A J, van Riel, Natal A W

“…Mathematical modeling is often used to formalize hypotheses on how a biochemical network operates by discriminating between competing models. Bayesian model…”
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Parameter trajectory analysis to identify treatment effects of pharmacological interventions by Tiemann, Christian A, Vanlier, Joep, Oosterveer, Maaike H, Groen, Albert K, Hilbers, Peter A J, van Riel, Natal A W

“…The field of medical systems biology aims to advance understanding of molecular mechanisms that drive disease progression and to translate this knowledge into…”
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Model-Based Quantification of the Systemic Interplay between Glucose and Fatty Acids in the Postprandial State by Sips, Fianne L P, Nyman, Elin, Adiels, Martin, Hilbers, Peter A J, Strålfors, Peter, van Riel, Natal A W, Cedersund, Gunnar

“…In metabolic diseases such as Type 2 Diabetes and Non-Alcoholic Fatty Liver Disease, the systemic regulation of postprandial metabolite concentrations is…”
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Self-Reproduction of Fatty Acid Vesicles: A Combined Experimental and Simulation Study by Markvoort, Albert J., Pfleger, Nicole, Staffhorst, Rutger, Hilbers, Peter A.J., van Santen, Rutger A., Killian, J. Antoinette, de Kruijff, Ben

“…Dilution of a fatty acid micellar solution at basic pH toward neutrality results in spontaneous formation of vesicles with a broad size distribution. However,…”
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