Search Results - "Hilbers, Hans W"

Cyclotriveratrylene (CTV) as a New Chiral Triacid Scaffold Capable of Inducing Triple Helix Formation of Collagen Peptides Containing either a Native Sequence or Pro-Hyp-Gly Repeats by Rump, Erik T., Rijkers, Dirk T. S., Hilbers, Hans W., de Groot, Philip G., Liskamp, Rob M. J.

“…A new triacid scaffold is described based on the cone‐shaped cyclotriveratrylene (CTV) molecule that facilitates the triple helical folding of peptides…”
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Synthesis of Bicyclic Alkene-/Alkane-Bridged Nisin Mimics by Ring-Closing Metathesis and their Biochemical Evaluation as Lipid II Binders: toward the Design of Potential Novel Antibiotics by Ghalit, Nourdin, Reichwein, John F, Hilbers, Hans W, Breukink, Eefjan, Rijkers, Dirk T.S, Liskamp, Rob M.J

“…This report describes the design, synthesis, and biochemical evaluation of alkene- and alkane-bridged AB(C)-ring mimics of the lantibiotic nisin. Nisin belongs…”
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Step-wise and pre-organization induced synthesis of a crossed alkene-bridged nisin Z DE-ring mimic by ring-closing metathesis by Ghalit, Nourdin, Kemmink, Johan, Hilbers, Hans W, Versluis, Cees, Rijkers, Dirk T S, Liskamp, Rob M J

“…This paper describes two approaches for the synthesis of a crossed alkene-bridged mimic of the thioether ring system of the nisin Z DE-fragment. The first…”
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Alkene/alkane-bridged mimics of the lantibiotic nisin: toward novel peptide-based antibiotics by Harmsen, Rianne A G, Ghalit, Nourdin, Kemmink, Johan, Hilbers, Hans W, Breukink, Eefjan, Rijkers, Dirk T S, Liskamp, Rob M J

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Ring-closing metathesis for the synthesis of side chain knotted pentapeptides inspired by vancomycin by ten Brink, Hefziba T, Rijkers, Dirk T S, Kemmink, Johan, Hilbers, Hans W, Liskamp, Rob M J

“…A versatile method for the synthesis of bicyclic side chain knotted peptides inspired by vancomycin is described. The synthetic approach is based on the…”
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Role of solution conformation and flexibility of short peptide ligands that bind to the p56(lck) SH2 domain by Dekker, Frank J, de Mol, Nico J, Bultinck, Patrick, Kemmink, Johan, Hilbers, Hans W, Liskamp, Rob M J

“…A general approach in drug design is making ligands more rigid in order to avoid loss in conformational entropy (deltaS(conf)) upon receptor binding. We…”
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Generate: A program for 3-D structure generation and conformational analysis of peptides and peptidomimetics by Bultinck, Patrick, Augustynen, Stijn, Hilbers, Hans W., Moret, Ed E., Tollenaere, Jan P.

“…The program Generate, aimed at generating 3‐D structures for peptides and peptidomimetics, is presented. The algorithm is based on a build‐up procedure, using…”
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In Vivo Activity and Hydrophobicity of Cytostatic Aziridinyl Quinones by Moret, Ed E, de Boer, Mark, Hilbers, Hans W, Tollenaere, Jan P, Janssen, Lambert H. M, Holthuis, Joost J. M, Driebergen, Reinoud J, Verboom, Willem, Reinhoudt, David N

“…For a series of 3,6-disubstituted bisaziridinylbenzoquinones the in vivo and in vitro activities against murine tumors, as well as the in vivo toxicity, are…”
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Synthesis and biological evaluation of potent αvβ3-integrin receptor antagonists by Dijkgraaf, Ingrid, Kruijtzer, John A.W., Frielink, Cathelijne, Soede, Annemieke C., Hilbers, Hans W., Oyen, Wim J.G., Corstens, Frans H.M., Liskamp, Rob M.J., Boerman, Otto C.

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Synthesis and biological evaluation of potent α vβ 3-integrin receptor antagonists by Dijkgraaf, Ingrid, Kruijtzer, John A.W., Frielink, Cathelijne, Soede, Annemieke C., Hilbers, Hans W., Oyen, Wim J.G., Corstens, Frans H.M., Liskamp, Rob M.J., Boerman, Otto C.

“…α vβ 3 Integrin is expressed in sprouting endothelial cells in growing tumors, whereas it is absent in quiescent blood vessels. In addition, various tumor cell…”
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Synthesis and biological evaluation of potent alphavbeta3-integrin receptor antagonists by Dijkgraaf, Ingrid, Kruijtzer, John A W, Frielink, Cathelijne, Soede, Annemieke C, Hilbers, Hans W, Oyen, Wim J G, Corstens, Frans H M, Liskamp, Rob M J, Boerman, Otto C

“…alpha(v)beta(3) Integrin is expressed in sprouting endothelial cells in growing tumors, whereas it is absent in quiescent blood vessels. In addition, various…”
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Role of solution conformation and flexibility of short peptide ligands that bind to the p56 lck SH2 domain by Dekker, Frank J, de Mol, Nico J, Bultinck, Patrick, Kemmink, Johan, Hilbers, Hans W, Liskamp, Rob M.J

“…A general approach in drug design is making ligands more rigid in order to avoid loss in conformational entropy (Δ S conf) upon receptor binding. We…”
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Role of solution conformation and flexibility of short peptide ligands that bind to the p56lck SH2 domain by DEKKER, Frank J, DE MOL, Nico J, BULTINCK, Patrick, KEMMINK, Johan, HILBERS, Hans W, LISKAMP, Rob M. J

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Injections into fat instead of muscle

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