Search Results - "Hilberg, Frank"

Design, Synthesis, and Evaluation of Indolinones as Triple Angiokinase Inhibitors and the Discovery of a Highly Specific 6-Methoxycarbonyl-Substituted Indolinone (BIBF 1120) by Roth, Gerald J, Heckel, Armin, Colbatzky, Florian, Handschuh, Sandra, Kley, Jörg, Lehmann-Lintz, Thorsten, Lotz, Ralf, Tontsch-Grunt, Ulrike, Walter, Rainer, Hilberg, Frank

“…Inhibition of tumor angiogenesis through blockade of the vascular endothelial growth factor (VEGF) signaling pathway is a new treatment modality in oncology…”
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Epigenetic SMAD3 Repression in Tumor-Associated Fibroblasts Impairs Fibrosis and Response to the Antifibrotic Drug Nintedanib in Lung Squamous Cell Carcinoma by Ikemori, Rafael, Gabasa, Marta, Duch, Paula, Vizoso, Miguel, Bragado, Paloma, Arshakyan, Marselina, Luis, Iuliana-Cristiana, Marín, Albert, Morán, Sebastian, Castro, Manuel, Fuster, Gemma, Gea-Sorli, Sabrina, Jauset, Toni, Soucek, Laura, Montuenga, Luis M, Esteller, Manel, Monsó, Eduard, Peinado, Victor Ivo, Gascon, Pere, Fillat, Cristina, Hilberg, Frank, Reguart, Noemí, Alcaraz, Jordi

“…The tumor-promoting fibrotic stroma rich in tumor-associated fibroblasts (TAF) is drawing increased therapeutic attention. Intriguingly, a trial with the…”
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Therapeutic impact of Nintedanib with paclitaxel and/or a PD-L1 antibody in preclinical models of orthotopic primary or metastatic triple negative breast cancer by Reguera-Nuñez, Elaine, Xu, Ping, Chow, Annabelle, Man, Shan, Hilberg, Frank, Kerbel, Robert S

“…Triple negative breast cancer (TNBC) is an aggressive malignancy with poor prognosis, in part because of the current lack of any approved molecularly targeted…”
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Nintedanib and a bi-specific anti-VEGF/Ang2 nanobody selectively prevent brain metastases of lung adenocarcinoma cells by Kovalchuk, Bogdana, Berghoff, Anna S., Karreman, Matthia A., Frey, Katharina, Piechutta, Manuel, Fischer, Manuel, Grosch, Julia, Heiland, Sabine, Breckwoldt, Michael O., Hilberg, Frank, Wick, Wolfgang, Winkler, Frank

“…Brain metastases (BM) are an ever-increasing challenge in oncology, threatening quality of life and survival of many cancer patients. The majority of BM…”
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Nintedanib Is Active in Malignant Pleural Mesothelioma Cell Models and Inhibits Angiogenesis and Tumor Growth In Vivo by Laszlo, Viktoria, Valko, Zsuzsanna, Kovacs, Ildiko, Ozsvar, Judit, Hoda, Mir Alireza, Klikovits, Thomas, Lakatos, Dora, Czirok, Andras, Garay, Tamas, Stiglbauer, Alexander, Helbich, Thomas H, Gröger, Marion, Tovari, Jozsef, Klepetko, Walter, Pirker, Christine, Grusch, Michael, Berger, Walter, Hilberg, Frank, Hegedus, Balazs, Dome, Balazs

“…Malignant pleural mesothelioma (MPM) is an aggressive thoracic tumor type with limited treatment options and poor prognosis. The angiokinase inhibitor…”
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Enhancing gastric cancer conventional chemotherapy effects by triple angiokinase inhibitor nintedanib in preclinical models by Awasthi, Niranjan, Schwarz, Margaret A, Kaurich, Quinn, Zhang, Changhua, Hilberg, Frank, Schwarz, Roderich E

“…Gastric adenocarcinoma (GAC) is the fourth leading cause of cancer death worldwide. Systemic chemotherapy is a preferred treatment option for advanced and…”
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CD44 Suppresses TLR-Mediated Inflammation by Kawana, Hidetada, Karaki, Hirokazu, Higashi, Morihiro, Miyazaki, Masaru, Hilberg, Frank, Kitagawa, Motoo, Harigaya, Kenichi

“…The cell adhesion molecule CD44, which is the major hyaluronan receptor, has been implicated in the binding, endocytosis, and metabolism of hyaluronan…”
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Functions of c-Jun in Liver and Heart Development by Eferl, Robert, Sibilia, Maria, Hilberg, Frank, Fuchsbichler, Andrea, Kufferath, Iris, Guertl, Barbara, Zenz, Rainer, Wagner, Erwin F., Zatloukal, Kurt

“…Mice lacking the AP-1 transcription factor c-Jun die around embryonic day E13.0 but little is known about the cell types affected as well as the cause of…”
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Bortezomib, Dexamethasone, and Fibroblast Growth Factor Receptor 3–Specific Tyrosine Kinase Inhibitor in t(4;14) Myeloma by BISPING, Guido, WENNING, Doris, VOLPERT, Sarah, MESTERS, Rolf M, BERDEL, Wolfgang E, KIENAST, Joachim, KROPFF, Martin, GUSTAVUS, Dirk, MÜLLER-TIDOW, Carsten, STELLJES, Matthias, MUNZERT, Gerd, HILBERG, Frank, ROTH, Gerald J, STEFANIC, Martin

“…Purpose: Novel drugs including targeted approaches have changed treatment paradigms for multiple myeloma (MM) and may also have therapeutic potential in the…”
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CD44 is a determinant of inflammatory bone loss by Hayer, Silvia, Steiner, Günter, Görtz, Birgit, Reiter, Erika, Tohidast-Akrad, Makiyeh, Amling, Michael, Hoffmann, Oskar, Redlich, Kurt, Zwerina, Jochen, Skriner, Karl, Hilberg, Frank, Wagner, Erwin F, Smolen, Josef S, Schett, Georg

“…Chronic inflammation is a major trigger of local and systemic bone loss. Disintegration of cell-matrix interaction is a prerequisite for the invasion of…”
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Growth inhibition and induction of apoptosis in acute myeloid leukemia cells by new indolinone derivatives targeting fibroblast growth factor, platelet-derived growth factor, and vascular endothelial growth factor receptors by Kulimova, Emma, Oelmann, Elisabeth, Bisping, Guido, Kienast, Joachim, Mesters, Rolf M., Schwäble, Joachim, Hilberg, Frank, Roth, Gerald J., Munzert, Gerd, Stefanic, Martin, Steffen, Björn, Brandts, Christian, Müller-Tidow, Carsten, Kolkmeyer, Astrid, Büchner, Thomas, Serve, Hubert, Berdel, Wolfgang E.

“…In acute myeloid leukemia (AML), receptor tyrosine kinase ligands promote growth and survival and contribute to AML-associated marrow neoangiogenesis. We have…”
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Nintedanib: From Discovery to the Clinic by Roth, Gerald J, Binder, Rudolf, Colbatzky, Florian, Dallinger, Claudia, Schlenker-Herceg, Rozsa, Hilberg, Frank, Wollin, Stefan-Lutz, Kaiser, Rolf

“…Nintedanib (BIBF1120) is a potent, oral, small-molecule tyrosine kinase inhibitor, also known as a triple angiokinase inhibitor, inhibiting three major…”
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Abstract 1043: Enhancing cytotoxic chemotherapy effects by nintedanib in gastric cancer preclinical models by Awasthi, Niranjan, Schwarz, Margaret A., Hilberg, Frank, Schwarz, Roderich E.

“…Abstract Background: Gastric adenocarcinoma (GAC) remains the 3rd most common cause of cancer mortality in the world. Systemic chemotherapy is a preferred…”
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Drug resistance profiles of mutations in the RET kinase domain by Liu, Xuan, Shen, Tao, Mooers, Blaine H M, Hilberg, Frank, Wu, Jie

“…Background and Purpose Alterations in the tyrosine kinase enzyme RET are found in thyroid and lung cancer. While RET TK inhibitors (TKIs) are used to treat…”
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Abstract 2869: Nintedanib abrogates the activation and tumor-promoting effects of fibroblasts from lung adenocarcinoma patients by Alcaraz, Jordi, Gabasa, Marta, Ikemori, Rafael, Hilberg, Frank, Reguart, Noemí

“…Abstract Nintedanib is a clinically-approved multikinase receptor inhibitor that, in combination with docetaxel, provides clinical benefits to advanced lung…”
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Structural basis of resistance of mutant RET protein-tyrosine kinase to its inhibitors nintedanib and vandetanib by Terzyan, Simon S., Shen, Tao, Liu, Xuan, Huang, Qingling, Teng, Peng, Zhou, Mi, Hilberg, Frank, Cai, Jianfeng, Mooers, Blaine H.M., Wu, Jie

“…RET is a transmembrane growth factor receptor. Aberrantly activated RET is found in several types of human cancer and is a target for treating RET…”
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Abstract 2982: Unraveling the antifibrotic mode of action of nintedanib against the TGF-β pathway in tumor-associated fibroblasts in non-small cell lung cancer by Ikemori, Rafael, Gabasa, Marta, Duch, Paula, Hilberg, Frank, Reguart, Noemí, Alcaraz, Jordi

“…Abstract Non-small cell lung cancer (NSCLC) is the leading cause of cancer related death, and its major histotypes are lung adenocarcinoma (ADC) and squamous…”
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BIBF 1120: triple angiokinase inhibitor with sustained receptor blockade and good antitumor efficacy by Hilberg, Frank, Roth, Gerald J, Krssak, Martin, Kautschitsch, Susanna, Sommergruber, Wolfgang, Tontsch-Grunt, Ulrike, Garin-Chesa, Pilar, Bader, Gerd, Zoephel, Andreas, Quant, Jens, Heckel, Armin, Rettig, Wolfgang J

“…Inhibition of tumor angiogenesis through blockade of the vascular endothelial growth factor (VEGF) signaling pathway is a novel treatment modality in oncology…”
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Tumour-infiltrating neutrophils counteract anti-VEGF therapy in metastatic colorectal cancer by Schiffmann, Lars Mortimer, Fritsch, Melanie, Gebauer, Florian, Günther, Saskia Diana, Stair, Neil Richard, Seeger, Jens Michael, Thangarajah, Fabinshy, Dieplinger, Georg, Bludau, Marc, Alakus, Hakan, Göbel, Heike, Quaas, Alexander, Zander, Thomas, Hilberg, Frank, Bruns, Christiane Josephine, Kashkar, Hamid, Coutelle, Oliver

“…Background Immune infiltration is implicated in the development of acquired resistance to anti-angiogenic cancer therapy. We therefore investigated the…”
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Abstract B09: Nintedanib inhibits tumor and vessel growth and leads to vascular normalization in A549-NSCLC-xenografts by Ackermann, Maximilian, Hilberg, Frank, Konerding, Moritz Anton

“…Abstract Angiogenesis plays a major role in the growth and progression of non-small-cell lung cancer (NSCLC). The triple angiokinase inhibitor nintedanib is a…”
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