Search Results - "Hilary M. Collins"

Conofolidine: A Natural Plant Alkaloid That Causes Apoptosis and Senescence in Cancer Cells by Al-Hayali, Mohammed Zuhair, Nge, Choy-Eng, Lim, Kuan Hon, Collins, Hilary M, Kam, Toh-Seok, Bradshaw, Tracey D

“…Natural products contribute substantially to anticancer therapy; the plant kingdom provides an important source of molecules. Conofolidine is a novel bisindole…”
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Novel Semi-Synthetic Cu (II)-Cardamonin Complex Exerts Potent Anticancer Activity against Triple-Negative Breast and Pancreatic Cancer Cells via Inhibition of the Akt Signaling Pathway by Hossan, Md Shahadat, Break, Mohammed Khaled Bin, Bradshaw, Tracey D, Collins, Hilary M, Wiart, Christophe, Khoo, Teng-Jin, Alafnan, Ahmed

“…Cardamonin is a polyphenolic natural product that has been shown to possess cytotoxic activity against a variety of cancer cell lines. We previously reported…”
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p38 MAPK/MK2-mediated induction of miR-34c following DNA damage prevents Myc-dependent DNA replication by Cannell, Ian G, Kong, Yi W, Johnston, Samantha J, Chen, Melissa L, Collins, Hilary M, Dobbyn, Helen C, Elia, Androulla, Kress, Theresia R, Dickens, Martin, Clemens, Michael J, Heery, David M, Gaestel, Matthias, Eilers, Martin, Willis, Anne E, Bushell, Martin

“…The DNA damage response activates several pathways that stall the cell cycle and allow DNA repair. These consist of the well-characterized ATR (Ataxia…”
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Abnormal Clock Gene Expression and Locomotor Activity Rhythms in Two Month-Old Female APPSwe/PS1dE9 Mice by Oyegbami, Olaide, Collins, Hilary M, Pardon, Marie-Christine, Ebling, Francis J P, Heery, David M, Moran, Paula M

“…In addition to cognitive decline, Alzheimer's Disease (AD) is also characterized by agitation and disruptions in activity and sleep. These symptoms typically…”
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Differential effects of garcinol and curcumin on histone and p53 modifications in tumour cells by Collins, Hilary M, Abdelghany, Magdy K, Messmer, Marie, Yue, Baigong, Deeves, Sian E, Kindle, Karin B, Mantelingu, Kempegowda, Aslam, Akhmed, Winkler, G Sebastiaan, Kundu, Tapas K, Heery, David M

“…Post-translational modifications (PTMs) of histones and other proteins are perturbed in tumours. For example, reduced levels of acetylated H4K16 and…”
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Correction to “Apoferritin-Encapsulated Jerantinine A for Transferrin Receptor Targeting and Enhanced Selectivity in Breast Cancer Therapy” by Abuzaid, Haneen, Abdelrazig, Salah, Ferreira, Lenny, Collins, Hilary M., Kim, Dong-Hyun, Lim, Kuan-Hon, Kam, Toh-Seok, Thomas, Neil R., Turyanska, Lyudmila, Bradshaw, Tracey D.

“…[This corrects the article DOI: 10.1021/acsomega.2c00997.]…”
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PRAME is a golgi-targeted protein that associates with the Elongin BC complex and is upregulated by interferon-gamma and bacterial PAMPs by Wadelin, Frances R, Fulton, Joel, Collins, Hilary M, Tertipis, Nikolaos, Bottley, Andrew, Spriggs, Keith A, Falcone, Franco H, Heery, David M

“…Preferentially expressed antigen in melanoma (PRAME) has been described as a cancer-testis antigen and is associated with leukaemias and solid tumours. Here we…”
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PIP5K1α is Required for Promoting Tumor Progression in Castration-Resistant Prostate Cancer by Wang, Tianyan, Sarwar, Martuza, Whitchurch, Jonathan B, Collins, Hilary M, Green, Tami, Semenas, Julius, Ali, Amjad, Roberts, Christopher J, Morris, Ryan D, Hubert, Madlen, Chen, Sa, El-Schich, Zahra, Wingren, Anette G, Grundström, Thomas, Lundmark, Richard, Mongan, Nigel P, Gunhaga, Lena, Heery, David M, Persson, Jenny L

“…PIP5K1α has emerged as a promising drug target for the treatment of castration-resistant prostate cancer (CRPC), as it acts upstream of the PI3K/AKT signaling…”
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Correction: PRAME Is a Golgi-Targeted Protein That Associates with the Elongin BC Complex and Is Upregulated by Interferon-Gamma and Bacterial PAMPs by Wadelin, Frances R, Fulton, Joel, Collins, Hilary M, Tertipis, Nikolaos, Bottley, Andrew, Spriggs, Keith A, Falcone, Franco H, Heery, David M

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The double PHD finger domain of MOZ/MYST3 induces α-helical structure of the histone H3 tail to facilitate acetylation and methylation sampling and modification by Dreveny, Ingrid, Deeves, Sian E, Fulton, Joel, Yue, Baigong, Messmer, Marie, Bhattacharya, Amit, Collins, Hilary M, Heery, David M

“…Histone tail modifications control many nuclear processes by dictating the dynamic exchange of regulatory proteins on chromatin. Here we report novel insights…”
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MOZ-TIF2 Inhibits Transcription by Nuclear Receptors and p53 by Impairment of CBP Function by Kindle, Karin B., Troke, Philip J. F., Collins, Hilary M., Matsuda, Sachiko, Bossi, Daniela, Bellodi, Cristian, Kalkhoven, Eric, Salomoni, Paolo, Pelicci, Pier Giuseppe, Minucci, Saverio, Heery, David M.

“…Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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Cardiac glycoside cerberin exerts anticancer activity through PI3K/AKT/mTOR signal transduction inhibition by Hossan, Md Shahadat, Chan, Zi-Yang, Collins, Hilary M., Shipton, Fiona N., Butler, Mark S., Rahmatullah, Mohammed, Lee, Jong Bong, Gershkovich, Pavel, Kagan, Leonid, Khoo, Teng-Jin, Wiart, Christophe, Bradshaw, Tracey D.

“…Natural products possess a significant role in anticancer therapy and many currently-used anticancer drugs are of natural origin. Cerberin (CR), a cardenolide…”
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Global Histone Modifications in Breast Cancer Correlate with Tumor Phenotypes, Prognostic Factors, and Patient Outcome by ELSHEIKH, Somaia E, GREEN, Andrew R, GRAINGE, Matthew J, BALL, Graham R, ABDELGHANY, Magdy K, MARTINEZ-POMARES, Luisa, HEERY, David M, ELLIS, Ian O, RAKHA, Emad A, POWE, Des G, AHMED, Rabab A, COLLINS, Hilary M, SORIA, Daniele, GARIBALDI, Jonathan M, PAISH, Claire E, AMMAN, Amr A

“…Post-translational histone modifications are known to be altered in cancer cells, and loss of selected histone acetylation and methylation marks has recently…”
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Lipophilic activated ester prodrug approach for drug delivery to the intestinal lymphatic system by Lee, Jong Bong, Zgair, Atheer, Malec, Jed, Kim, Tae Hwan, Kim, Min Gi, Ali, Joseph, Qin, Chaolong, Feng, Wanshan, Chiang, Manting, Gao, Xizhe, Voronin, Gregory, Garces, Aimie E., Lau, Chun Long, Chan, Ting-Hoi, Hume, Amy, McIntosh, Tecashanell M., Soukarieh, Fadi, Al-Hayali, Mohammed, Cipolla, Elena, Collins, Hilary M., Heery, David M., Shin, Beom Soo, Yoo, Sun Dong, Kagan, Leonid, Stocks, Michael J., Bradshaw, Tracey D., Fischer, Peter M., Gershkovich, Pavel

“…The intestinal lymphatic system plays an important role in the pathophysiology of multiple diseases including lymphomas, cancer metastasis, autoimmune…”
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Functional Interaction of CREB Binding Protein (CBP) with Nuclear Transport Proteins and Modulation by HDAC Inhibitors by Ryan, Colm M., Harries, Janet C., Kindle, Karin B., Collins, Hilary M., Heery, David M.

“…Nuclear transport proteins such as CSE1, NUP93 and Importinα have recently been shown to be chromatin-associated proteins in yeast, which have unexpected…”
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Synthesis of micellar-like terpolymer nanoparticles with reductively-cleavable cross-links and evaluation of efficacy in 2D and 3D models of triple negative breast cancer by Monteiro, Patrícia F., Gulfam, Muhammad, Monteiro, Cíntia J., Travanut, Alessandra, Abelha, Thais Fedatto, Pearce, Amanda K., Jerôme, Christine, Grabowska, Anna M., Clarke, Philip A., Collins, Hilary M., Heery, David M., Gershkovich, Pavel, Alexander, Cameron

“…Triple negative or basal-like breast cancer (TNBC) is characterised by aggressive progression, lack of standard therapies and poorer overall survival rates for…”
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Apoferritin-Encapsulated Jerantinine A for Transferrin Receptor Targeting and Enhanced Selectivity in Breast Cancer Therapy by Abuzaid, Haneen, Abdelrazig, Salah, Ferreira, Lenny, Collins, Hilary M., Kim, Dong-Hyun, Lim, Kuan-Hon, Kam, Toh-Seok, Turyanska, Lyudmila, Bradshaw, Tracey D.

“…The O-acetyl (or acetate) derivative of the Aspidosperma alkaloid Jerantinine A (JAa) elicits anti-tumor activity against cancer cell lines including mammary…”
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A signature motif mediating selective interactions of BCL11A with the NR2E/F subfamily of orphan nuclear receptors by Chan, Chun Ming, Fulton, Joel, Montiel-Duarte, Cristina, Collins, Hilary M, Bharti, Neetu, Wadelin, Frances R, Moran, Paula M, Mongan, Nigel P, Heery, David M

“…Despite their physiological importance, selective interactions between nuclear receptors (NRs) and their cofactors are poorly understood. Here, we describe a…”
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Heterodimers of photoreceptor-specific nuclear receptor (PNR/NR2E3) and peroxisome proliferator-activated receptor-γ (PPARγ) are disrupted by retinal disease-associated mutations by Fulton, Joel, Mazumder, Bismoy, Whitchurch, Jonathan B, Monteiro, Cintia J, Collins, Hilary M, Chan, Chun M, Clemente, Maria P, Hernandez-Quiles, Miguel, Stewart, Elizabeth A, Amoaku, Winfried M, Moran, Paula M, Mongan, Nigel P, Persson, Jenny L, Ali, Simak, Heery, David M

“…Photoreceptor-specific nuclear receptor (PNR/NR2E3) and Tailless homolog (TLX/NR2E1) are human orthologs of the NR2E group, a subgroup of phylogenetically…”
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SUMOylation regulates the nuclear mobility of CREB binding protein and its association with nuclear bodies in live cells by Ryan, Colm M., Kindle, Karin B., Collins, Hilary M., Heery, David M.

“…The lysine acetyltransferase CREB binding protein (CBP) is required for chromatin modification and transcription at many gene promoters. In fixed cells, a…”
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