Search Results - "Hiken, Jeffrey F"

Discovering high-resolution patterns of differential DNA methylation that correlate with gene expression changes by Vanderkraats, Nathan D, Hiken, Jeffrey F, Decker, Keith F, Edwards, John R

“…Methylation of the CpG-rich region (CpG island) overlapping a gene's promoter is a generally accepted mechanism for silencing expression. While recent…”
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Endocrine-Therapy-Resistant ESR1 Variants Revealed by Genomic Characterization of Breast-Cancer-Derived Xenografts by Li, Shunqiang, Shen, Dong, Shao, Jieya, Crowder, Robert, Liu, Wenbin, Prat, Aleix, He, Xiaping, Liu, Shuying, Hoog, Jeremy, Lu, Charles, Ding, Li, Griffith, Obi L., Miller, Christopher, Larson, Dave, Fulton, Robert S., Harrison, Michelle, Mooney, Tom, McMichael, Joshua F., Luo, Jingqin, Tao, Yu, Goncalves, Rodrigo, Schlosberg, Christopher, Hiken, Jeffrey F., Saied, Laila, Sanchez, Cesar, Giuntoli, Therese, Bumb, Caroline, Cooper, Crystal, Kitchens, Robert T., Lin, Austin, Phommaly, Chanpheng, Davies, Sherri R., Zhang, Jin, Kavuri, Megha Shyam, McEachern, Donna, Dong, Yi Yu, Ma, Cynthia, Pluard, Timothy, Naughton, Michael, Bose, Ron, Suresh, Rama, McDowell, Reida, Michel, Loren, Aft, Rebecca, Gillanders, William, DeSchryver, Katherine, Wilson, Richard K., Wang, Shaomeng, Mills, Gordon B., Gonzalez-Angulo, Ana, Edwards, John R., Maher, Christopher, Perou, Charles M., Mardis, Elaine R., Ellis, Matthew J.

“…To characterize patient-derived xenografts (PDXs) for functional studies, we made whole-genome comparisons with originating breast cancers representative of…”
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The predominant mechanism of intercellular calcium wave propagation changes during long-term culture of human osteoblast-like cells by Henriksen, Zanne, Hiken, Jeffrey F., Steinberg, Thomas H., Jørgensen, Niklas R.

“…Intercellular calcium waves (ICW) are calcium transients that spread from cell to cell in response to different stimuli. We previously demonstrated that human…”
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DNMT gene expression and methylome in Marek's disease resistant and susceptible chickens prior to and following infection by MDV by Tian, Fei, Zhan, Fei, VanderKraats, Nathan D., Hiken, Jeffrey F., Edwards, John R., Zhang, Huanmin, Zhao, Keji, Song, Jiuzhou

“…Marek's disease (MD) is characterized as a T cell lymphoma induced by a cell-associated α-herpesvirus, Marek's disease virus type 1 (MDV1). As with many viral…”
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ATP downregulates P2X7 and inhibits osteoclast formation in RAW cells by Hiken, Jeffrey F, Steinberg, Thomas H

“…Multinucleated giant cells derive from fusion of precursor cells of the macrophage lineage. It has been proposed that the purinoreceptor P2X(7) is involved in…”
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P2 receptors in macrophage fusion and osteoclast formation by Steinberg, Thomas H, Hiken, Jeffrey F

“…Cells of the mononuclear phagocyte lineage fuse to form multinucleated giant cells and osteoclasts. Several lines of evidence suggest that P2 receptors, in…”
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Epigenetic activation of the prostaglandin receptor EP4 promotes resistance to endocrine therapy for breast cancer by Hiken, J F, McDonald, J I, Decker, K F, Sanchez, C, Hoog, J, VanderKraats, N D, Jung, K L, Akinhanmi, M, Rois, L E, Ellis, M J, Edwards, J R

“…Approximately 75% of breast cancers express estrogen receptor α (ERα) and depend on estrogen signals for continued growth. Aromatase inhibitors (AIs) prevent…”
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Stimulation of glucose transport and glucose transporter phosphorylation by okadaic acid in rat adipocytes by Lawrence, J C, Hiken, J F, James, D E

“…Okadaic acid, an inhibitor of Type I and IIa protein phosphatases, was recently found to stimulate 2-deoxyglucose uptake in rat adipocytes (Haystead, T. A. J.,…”
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Phosphorylation of the glucose transporter in rat adipocytes. Identification of the intracellular domain at the carboxyl terminus as a target for phosphorylation in intact-cells and in vitro by J C Lawrence, Jr, J F Hiken, D E James

“…Phosphorylation of the insulin-regulatable glucose transporter (IRGT) is increased by incubating rat adipocytes with isoproterenol or by incubating microsomal…”
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Rat skeletal muscle glycogen synthase: phosphorylation of the purified enzyme by cAMP-dependent and -independent protein kinases by Hiken, J F, Lawrence, Jr, J C

“…Glycogen synthase was purified to near homogeneity from rat skeletal muscle, and was found to resemble the rabbit skeletal muscle enzyme in several respects…”
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Glycogen synthase in rat adipocytes and skeletal muscle is phosphorylated on both serine and threonine by Hiken, Jeffrey F., Lawrence, John C.

“…Glycogen synthase is phosphorylated both in vivo and in vitro on multiple sites per subunit. All phosphorylations of the enzyme thus far identified occur on…”
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Insulin Stimulates the Generation of an Adipocyte Phosphoprotein That is Isolated with a Monoclonal Antibody against the Regulatory Subunit of Bovine Heart cAMP-Dependent Protein Kinase by Lawrence, John C., Hiken, Jeffrey F., Inkster, Michelle, Scott, Clay W., Mumby, Marc C.

“…Incubating 32P-labeled fat cells with insulin increased by as much as 80-fold the amount of 32Pi in a soluble species of apparent Mr 62,000. This species,…”
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