Search Results - "Hikabe, Orie"
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Reconstitution in vitro of the entire cycle of the mouse female germ line
Published in Nature (London) (10-11-2016)“…Using a protocol that recapitulates both meiosis and oocyte growth in vitro , the authors induce mouse pluripotent stem cells to differentiate into fully…”
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Reconstitution of mouse oogenesis in a dish from pluripotent stem cells
Published in Nature protocols (01-09-2017)“…This protocol extension describes how to obtain functionally mature oocytes from embryonic or induced pluripotent stem cells. These oocytes can be used to…”
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Induction of primordial germ cell-like cells from common marmoset embryonic stem cells by inhibition of WNT and retinoic acid signaling
Published in Scientific reports (23-02-2023)“…Reconstitution of the germ cell lineage using pluripotent stem cells provides a unique platform to deepen our understanding of the mechanisms underlying germ…”
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Germ cell-intrinsic effects of sex chromosomes on early oocyte differentiation in mice
Published in PLoS genetics (26-03-2020)“…A set of sex chromosomes is required for gametogenesis in both males and females, as represented by sex chromosome disorders causing agametic phenotypes…”
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Generation of germ cells in vitro in the era of induced pluripotent stem cells
Published in Molecular reproduction and development (01-01-2014)“…SUMMARY Induced pluripotent stem cells (iPSCs) are stem cells that can be artificially generated via “cellular reprogramming” using gene transduction in…”
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Sphere-formation culture of testicular germ cells in the common marmoset, a small New World monkey
Published in Primates (01-01-2016)“…Spermatogonia are specialized cells responsible for continuous spermatogenesis and the production of offspring. Because of this biological property, in vitro…”
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Hypoxia induces the dormant state in oocytes through expression of Foxo3
Published in Proceedings of the National Academy of Sciences - PNAS (18-06-2019)“…In mammals, most immature oocytes remain dormant in the primordial follicles to ensure the longevity of female reproductive life. A precise understanding of…”
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Reconstitution of the oocyte transcriptional network with transcription factors
Published in Nature (London) (14-01-2021)“…During female germline development, oocytes become a highly specialized cell type and form a maternal cytoplasmic store of crucial factors. Oocyte growth is…”
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