Search Results - "Higuchi, Chikahisa"

Orthopedic Complications and Management in Children with X-Linked Hypophosphatemia by Higuchi, Chikahisa

“…X-linked hypophosphatemia is an inheritable disease of renal phosphate wasting that results in clinically manifestations associated with rickets or…”
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IL-6 negatively regulates osteoblast differentiation through the SHP2/MEK2 and SHP2/Akt2 pathways in vitro by Kaneshiro, Shoichi, Ebina, Kosuke, Shi, Kenrin, Higuchi, Chikahisa, Hirao, Makoto, Okamoto, Michio, Koizumi, Kota, Morimoto, Tokimitsu, Yoshikawa, Hideki, Hashimoto, Jun

“…It has been suggested that interleukin-6 (IL-6) plays a key role in the pathogenesis of rheumatoid arthritis (RA), including osteoporosis not only in inflamed…”
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An overgrowth disorder associated with excessive production of cGMP due to a gain-of-function mutation of the natriuretic peptide receptor 2 gene by Miura, Kohji, Namba, Noriyuki, Fujiwara, Makoto, Ohata, Yasuhisa, Ishida, Hidekazu, Kitaoka, Taichi, Kubota, Takuo, Hirai, Haruhiko, Higuchi, Chikahisa, Tsumaki, Noriyuki, Yoshikawa, Hideki, Sakai, Norio, Michigami, Toshimi, Ozono, Keiichi

“…We describe a three-generation family with tall stature, scoliosis and macrodactyly of the great toes and a heterozygous p.Val883Met mutation in Npr2, the gene…”
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Hyaluronan inhibits BMP-induced osteoblast differentiation by Kaneko, Keiko, Higuchi, Chikahisa, Kunugiza, Yasuo, Yoshida, Kiyoshi, Sakai, Takashi, Yoshikawa, Hideki, Nakata, Ken

“…•We observed the effects of HA on bone morphogenetic protein (BMP)-induced osteoblastic differentiation in C2C12 and ST2 cells.•BMP-induced osteoblastic…”
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Is hip dysplasia a common deformity in skeletally mature patients with hereditary multiple exostoses? by Higuchi, Chikahisa, Sugano, Nobuhiko, Yoshida, Kiyoshi, Yoshikawa, Hideki

“…Various deformities appear in hereditary multiple exostoses (HMEs). Deformities around the knee or ankle joints are easy to detect in this disease because such…”
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Transient dynamic actin cytoskeletal change stimulates the osteoblastic differentiation by Higuchi, Chikahisa, Nakamura, Norimasa, Yoshikawa, Hideki, Itoh, Kazuyuki

“…Dynamic cytoskeletal changes appear to be one of intracellular signals that control cell differentiation. To test this hypothesis, we examined the effects of…”
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In vitro generation of a scaffold-free tissue-engineered construct (TEC) derived from human synovial mesenchymal stem cells: biological and mechanical properties and further chondrogenic potential by Ando, Wataru, Tateishi, Kosuke, Katakai, Daisuke, Hart, David A, Higuchi, Chikahisa, Nakata, Ken, Hashimoto, Jun, Fujie, Hiromichi, Shino, Konsei, Yoshikawa, Hideki, Nakamura, Norimasa

“…The purpose of this study was to characterize a tissue-engineered construct (TEC) generated with human synovial mesenchymal stem cells (MSCs). MSCs were…”
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Bruton tyrosine kinase (Btk) suppresses osteoblastic differentiation by Kaneshiro, Shoichi, Ebina, Kosuke, Shi, Kenrin, Yoshida, Kiyoshi, Otsuki, Dai, Yoshikawa, Hideki, Higuchi, Chikahisa

“…The Tec family of nonreceptor tyrosine kinases has been shown to play a key role in inflammation and bone destruction. Bruton tyrosine kinase (Btk) has been…”
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Treatment of Partial Growth Arrest Using an In Vitro-generated Scaffold-free Tissue-engineered Construct Derived From Rabbit Synovial Mesenchymal Stem Cells by Yoshida, Kiyoshi, Higuchi, Chikahisa, Nakura, Akio, Nakamura, Norimasa, Yoshikawa, Hideki

“…BACKGROUND:Injuries to the epiphyseal plate sometimes result in partial growth arrest, which can lead to the development of angular deformities and limb length…”
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Continuous Inhibition of MAPK Signaling Promotes the Early Osteoblastic Differentiation and Mineralization of the Extracellular Matrix by Higuchi, Chikahisa, Myoui, Akira, Hashimoto, Nobuyuki, Kuriyama, Kohji, Yoshioka, Kiyoko, Yoshikawa, Hideki, Itoh, Kazuyuki

“…We screened the small molecule compounds that stimulate osteogenesis by themselves or promote bone morphogenetic protein (BMP)‐induced bone formation. We found…”
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Inorganic polyphosphate differentiates human mesenchymal stem cells into osteoblastic cells by Morimoto, Daiki, Tomita, Tetsuya, Kuroda, Shoko, Higuchi, Chikahisa, Kato, Shinichi, Shiba, Toshikazu, Nakagami, Hironori, Morishita, Ryuichi, Yoshikawa, Hideki

“…The existence of inorganic polyphosphates [poly(P)] in human cells has been demonstrated. In osteoblasts, it is suggested that the concentration of cellular…”
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Expression of noggin, an antagonist of bone morphogenetic protein, in schwannoma: A possible mechanism by KANEKO, KEIKO, HIGUCHI, CHIKAHISA, NAKA, NORIFUMI, YOSHIKAWA, HIDEKI

“…Schwannoma is a benign peripheral nerve sheath tumor derived from Schwann cells. Bone scalloping, including spinal foramen enlargement, develops when the tumor…”
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Pachydermodactyly Treated with Tranilast in a Young Girl by Higuchi, Chikahisa, Yoshikawa, Hideki, Tomita, Tetsuya

“…Introduction. Pachydermodactyly is a rare disease with asymptomatic swelling of proximal interphalangeal joints. This disorder should be considered in the…”
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Scaffold-free tissue-engineered construct-hydroxyapatite composites generated by an alternate soaking process: potential for repair of bone defects by Matsusaki, Michiya, Kadowaki, Koji, Tateishi, Kosuke, Higuchi, Chikahisa, Ando, Wataru, Hart, David A, Tanaka, Yoshinari, Take, Yasuhiro, Akashi, Mitsuru, Yoshikawa, Hideki, Nakamura, Norimasa

“…Mesenchymal stem cell (MSC)-based tissue-engineered construct (TEC)-hydroxyapatite (HAp) composites were developed by an alternate soaking process. The TEC…”
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Osteoporosis and bone morphogenetic protein (BMP) by Higuchi, Chikahisa, Nakase, Takanobu

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Donor Foot Morbidity Following Nonvascularized Toe Phalanx Transfer Utilizing a New Reconstruction Technique by Kawabata, Hidehiko, Okuno, Kyoko, Tamura, Daisuke, Higuchi, Chikahisa, Goldfarb, Charles A.

“…Nonvascularized toe phalanx transfer is an accepted surgical option for short and hypoplastic digits in congenital hand abnormalities. However, one of the…”
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Bone morphogenetic proteins by Higuchi, Chikahisa, Yoshikawa, Hideki

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Neogenin, a Receptor for Bone Morphogenetic Proteins by Hagihara, Meiko, Endo, Mitsuharu, Hata, Katsuhiko, Higuchi, Chikahisa, Takaoka, Kunio, Yoshikawa, Hideki, Yamashita, Toshihide

“…Bone morphogenetic proteins (BMPs) regulate many mammalian physiologic and pathophysiologic processes. These proteins bind with the kinase receptors BMPR-I and…”
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PKCα suppresses osteoblastic differentiation by Nakura, Akio, Higuchi, Chikahisa, Yoshida, Kiyoshi, Yoshikawa, Hideki

“…Abstract Protein kinase C (PKC) plays an essential role in cellular signal transduction for mediating a variety of biological functions. There are 11 PKC…”
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Zoledronate Therapy for the Pathological Humeral Fracture in Polyostotic Fibrous Dysplasia: A Case Report by Ohno, Ikko, Higuchi, Chikahisa

“…Fibrous dysplasia (FD) of bone is a rare skeletal disease often associated with bone pain, deformities and fractures. The bisphosphonate therapies are reported…”
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