Search Results - "Higuchi, Akihiro"

Suppression of presbyopia progression with pirenoxine eye drops: experiments on rats and non-blinded, randomized clinical trial of efficacy by Tsuneyoshi, Yukari, Higuchi, Akihiro, Negishi, Kazuno, Tsubota, Kazuo

“…Various methods can correct presbyopia, but all require devices or surgeries. Recently, supplements or warming devices to relieve presbyopic symptoms have been…”
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Author Correction: Suppression of presbyopia progression with pirenoxine eye drops: experiments on rats and non-blinded, randomized clinical trial of efficacy by Tsuneyoshi, Yukari, Higuchi, Akihiro, Negishi, Kazuno, Tsubota, Kazuo

“…An amendment to this paper has been published and can be accessed via a link at the top of the paper…”
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Selenium compound protects corneal epithelium against oxidative stress by Higuchi, Akihiro, Inoue, Hiroyoshi, Kawakita, Tetsuya, Ogishima, Tadashi, Tsubota, Kazuo

“…The ocular surface is strongly affected by oxidative stress, and anti-oxidative systems are maintained in corneal epithelial cells and tear fluid. Dry eye is…”
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Selenoprotein P controls oxidative stress in cornea by Higuchi, Akihiro, Takahashi, Kazuhiko, Hirashima, Masaki, Kawakita, Tetsuya, Tsubota, Kazuo

“…The ocular surface is always attacked by oxidative stress, and cornea epithelial cells are supposed to have their own recovery system against oxidative stress…”
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Diclofenac protects cultured human corneal epithelial cells against hyperosmolarity and ameliorates corneal surface damage in a rat model of dry eye by Sawazaki, Ryoichi, Ishihara, Tomoaki, Usui, Shinya, Hayashi, Erika, Tahara, Kayoko, Hoshino, Tatsuya, Higuchi, Akihiro, Nakamura, Shigeru, Tsubota, Kazuo, Mizushima, Tohru

“…Dry eye syndrome (DES) is characterized by an increase in tear osmolarity and induction of the expression and nuclear localization of an osmoprotective…”
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The Effect of Nrf2 Knockout on Ocular Surface Protection from Acute Tobacco Smoke Exposure by Kojima, Takashi, Dogru, Murat, Higuchi, Akihiro, Nagata, Taeko, Ibrahim, Osama M.A, Inaba, Takaaki, Tsubota, Kazuo

“…Ocular surface mucosa is the first-line ocular tissue to be exposed to environmental stress. We evaluated tear functions and keratoconjunctival epithelial…”
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The Antiaging Approach for the Treatment of Dry Eye by Tsubota, Kazuo, Kawashima, Motoko, Inaba, Takaaki, Dogru, Murat, Matsumoto, Yukihiro, Ishida, Reiko, Kaido, Minako, Kojima, Takashi, Uchino, Miki, Uchino, Yuichi, Ogawa, Yoko, Nakamura, Shigeru, Higuchi, Akihiro, Shinmura, Ken, Watanabe, Mitsuhiro, Kawakita, Tetsuya

“…Dry eye is one of the most common eye disorders affecting millions of people. It causes ocular irritation or discomfort, and decreases functional vision,…”
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Development of New Pharmaceutical Candidates With Antioxidant Activity for the Treatment of Corneal Disorders by Higuchi, Akihiro

“…The ocular surface is continuously exposed to physical and chemical factors in the environment. Oxidative stress, which strongly affects the ocular surface, is…”
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The Role of Fractalkine as an Accelerating Factor on the Autoimmune Exocrinopathy in Mice by Tsubota, Kazuo, Nishiyama, Tatsuaki, Mishima, Kenji, Inoue, Hiroko, Doi, Takeshi, Hattori, Yukio, Kodama, Tatsuhiko, Higuchi, Akihiro, Hayashi, Yoshio, Saito, Ichiro

“…Sjögren's syndrome (SS) is an organ-specific autoimmune disease caused by the progressive loss of exocrine glands and is associated with several autoimmune…”
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Inhibitory activity of epigallocatechin gallate (EGCg) in paraquat-induced microsomal lipid peroxidation—a mechanism of protective effects of EGCg against paraquat toxicity by Higuchi, Akihiro, Yonemitsu, Kosei, Koreeda, Ako, Tsunenari, Shigeyuki

“…Recently we have reported that epigallocatechin gallate (EGCg), a major component of Japanese green tea, significantly increased the survival rate of paraquat…”
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The era of antiaging ophthalmology comes of age: antiaging approach for dry eye treatment by Tsubota, Kazuo, Kawashima, Motoko, Inaba, Takaaki, Dogru, Murat, Ogawa, Yoko, Nakamura, Shigeru, Shinmura, Ken, Higuchi, Akihiro, Kawakita, Tetsuya

“…Recent advances in the understanding of aging have paved a new way of thinking about intervening with the aging process. There is a global agreement in the…”
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Autologous Serum and Serum Components by Higuchi, Akihiro

“…Dry eye syndrome is a multifactorial condition on the tear and ocular surface. Autologous serum eye drop is an effective method for treating dry eye…”
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Abstract 4124277: Resorcimoline, a Novel Free Radical Scavenger, Exhibits Cardioprotective Effects Following Coronary Ischemia-reperfusion Injury by Ueno, Kazuhiro, Mulorz, Joscha, Yoshimura, Kenshi, Mori, Kazuki, Kawashima, Takayuki, Nishida, Haruto, Higuchi, Akihiro, Tokumaru, Osamu, Miyamoto, Shinji

“…Abstract only Background: Ischemic heart disease remains the leading cause of death worldwide. Early coronary revascularization is the most important…”
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Serum application for the treatment of ocular surface disorders by Tsubota, K, Higuchi, A

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Long-term outcome of focal segmental glomerulosclerosis after Japanese pediatric renal transplantation by FUJISAWA, Masato, IIJIMA, Kazumoto, KAMIDONO, Sadao, ISHIMURA, Takeshi, HIGUCHI, Akihiro, ISOTANI, Shuji, YOSHIYA, Kunihiko, ARAKAWA, Soichi, HAMAMI, Gaku, MATSUMOTO, Osamu, YOSHIKAWA, Norishige

“…Focal segmental glomerulosclerosis (FSGS) is known to recur in some patients after renal transplantation. Over a prolonged period, we followed 13 pediatric…”
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Selenium-binding lactoferrin is taken into corneal epithelial cells by a receptor and prevents corneal damage in dry eye model animals by Higuchi, Akihiro, Inoue, Hiroyoshi, Kaneko, Yoshio, Oonishi, Erina, Tsubota, Kazuo

“…The ocular surface is strongly affected by oxidative stress, which causes many ocular diseases including dry eye. Previously, we showed that selenium…”
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Delivery of Hydrophobic Drugs to the Posterior Ocular Region by Gel-in-Water Nanoemulsion by Fardous, Jannatul, Inoue, Yuuta, Yoshida, Kozue, Ono, Fumiyasu, Higuchi, Akihiro, Ijima, Hiroyuki

“…The aim of this study was to develop a nanogel emulsion as a minimally invasive, safe, and effective treatment alternative for posterior ocular diseases. A…”
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Autologous Serum Eye Drops for the Treatment of Dry Eye Diseases by Kojima, Takashi, Higuchi, Akihiro, Goto, Eiki, Matsumoto, Yukihiro, Dogru, Murat, Tsubota, Kazuo

“…Conventional treatment of dry eye mainly consists of the use of preservative-free artificial eye drops and punctal occlusion. None of the commercially…”
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Corneal damage and lacrimal gland dysfunction in a smoking rat model by Higuchi, Akihiro, Ito, Kaori, Dogru, Murat, Kitamura, Masanori, Mitani, Fumiko, Kawakita, Tetsuya, Ogawa, Yoko, Tsubota, Kazuo

“…Smoking is a serious public health problem around the world and causes many diseases such as chronic obstructive pulmonary disease, lung cancer, and some eye…”
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Evaluation of treatment for dry eye with 2-hydroxyestradiol using a dry eye rat model by Higuchi, Akihiro, Oonishi, Erina, Kawakita, Tetsuya, Tsubota, Kazuo

“…2-hydroxy estradiol (2-OHE2) is a catechol derivative of 17β -Estradiol (E2) and it is synthesized from E2 catalyzed by cytochrome P4501A1. Previous studies…”
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