Plasma protein binding of drugs as a function of age in adult human subjects

The intent of this study was to determine what influence, if any, increasing age has on the binding of drugs by plasma proteins. Plasma from healthy subjects ranging in age from 21 to 94 years was used. The binding of phenytoin (diphenylhydantoin) (acid), penicillin G potassium (benzylpenicillin pot...

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Bibliographic Details
Published in:	Journal of pharmaceutical sciences Vol. 64; no. 10; p. 1711
Main Authors:	Bender, A D, Post, A, Meier, J P, Higson, J E, Reichard, Jr, G
Format:	Journal Article
Language:	English
Published:	United States 01-10-1975
Subjects:	Adult Aged Aging Alanine Transaminase - blood Alkaline Phosphatase - blood Aspartate Aminotransferases - blood Blood Proteins - metabolism Blood Urea Nitrogen Humans In Vitro Techniques Middle Aged Penicillin G - blood Phenobarbital - blood Phenytoin - blood Protein Binding Serum Albumin - analysis Serum Globulins - analysis
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Summary:	The intent of this study was to determine what influence, if any, increasing age has on the binding of drugs by plasma proteins. Plasma from healthy subjects ranging in age from 21 to 94 years was used. The binding of phenytoin (diphenylhydantoin) (acid), penicillin G potassium (benzylpenicillin potassium), and phenobarbituric acid was determined by equilibrium dialysis of 14C-labeled compounds. No differences were found in total protein concentration; however, albumin was reduced in subjects over 50 years of age. Plasma binding of each drug studied was not related to age; this finding suggests that age per se is not a factor in the binding of drugs by plasma proteins.
ISSN:	0022-3549
DOI:	10.1002/jps.2600641030